Search Results - "Caplan, AI"

Why are MSCs therapeutic? New data: new insight by Caplan, AI

“…Adult marrow-derived mesenchymal stem cells (MSCs) are able to differentiate into bone, cartilage, muscle, marrow stroma, tendon-ligament, fat and other…”
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Mesenchymal stem cells: mechanisms of inflammation by Singer, Nora G, Caplan, Arnold I

“…In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and are defined by their capacity to differentiate into bone, cartilage, and…”
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New era of cell-based orthopedic therapies by Caplan, Arnold I

“…There has long been a described relationship between mesenchymal stem cells (MSCs) and blood vessels in aspects of bone and other skeletal tissues with regard…”
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Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis by Bai, Lianhua, Lennon, Donald P., Eaton, Valerie, Maier, Kari, Caplan, Arnold I., Miller, Stephen D., Miller, Robert H.

“…Cell‐based therapies are attractive approaches to promote myelin repair. Recent studies demonstrated a reduction in disease burden in mice with experimental…”
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Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering by Park, Hansoo, Temenoff, Johnna S, Tabata, Yasuhiko, Caplan, Arnold I, Mikos, Antonios G

“…Abstract We investigated the development of an injectable, biodegradable hydrogel composite of oligo(poly(ethylene glycol) fumarate) (OPF) with encapsulated…”
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Fibroblast heterogeneity: more than skin deep by Sorrell, J Michael, Caplan, Arnold I

“…Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at…”
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Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix by Diekman, Brian O, Rowland, Christopher R, Lennon, Donald P, Caplan, Arnold I, Guilak, Farshid

“…Adipose-derived stem cells (ASCs) and bone marrow-derived mesenchymal stem cells (MSCs) are multipotent adult stem cells with potential for use in cartilage…”
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Influence of adult mesenchymal stem cells on in vitro vascular formation by Sorrell, J Michael, Baber, Marilyn A, Caplan, Arnold I

“…The effective delivery of bioactive molecules to wound sites hasten repair. Cellular therapies provide a means for the targeted delivery of a complex, multiple…”
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Human bone marrow-derived mesenchymal stem cells rescue neonatal CPAP-induced airway hyperreactivity by MacFarlane, PM, Mayer, CA, Caplan, AI, Raffay, TM, Mayer, AJ, Bonfield, TL

“…Continuous positive airway pressure (CPAP) is a primary non-invasive mode of respiratory support for preterm infants. However, emerging evidence suggests CPAP…”
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Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells by Solchaga, Luis A, Penick, Kitsie, Goldberg, Victor M, Caplan, Arnold I, Welter, Jean F

“…We compared human mesenchymal stem cells (hMSCs), expanded long term with and without fibroblast growth factor (FGF) supplementation, with respect to…”
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A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential by Kögler, Gesine, Sensken, Sandra, Airey, Judith A, Trapp, Thorsten, Müschen, Markus, Feldhahn, Niklas, Liedtke, Stefanie, Sorg, Rüdiger V, Fischer, Johannes, Rosenbaum, Claudia, Greschat, Susanne, Knipper, Andreas, Bender, Jörg, Degistirici, Ozer, Gao, Jizong, Caplan, Arnold I, Colletti, Evan J, Almeida-Porada, Graça, Müller, Hans W, Zanjani, Esmail, Wernet, Peter

“…Here a new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described. This rare…”
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FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells by Solchaga, Luis A., Penick, Kitsie, Porter, John D., Goldberg, Victor M., Caplan, Arnold I., Welter, Jean F.

“…Human mesenchymal stem cells (hMSCs) expanded with and without fibroblast growth factor (FGF) supplementation were compared with respect to their proliferation…”
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Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone by Grayson, Warren L, Bhumiratana, Sarindr, Cannizzaro, Christopher, Chao, P-H Grace, Lennon, Donald P, Caplan, Arnold I, Vunjak-Novakovic, Gordana

“…We describe a novel bioreactor system for tissue engineering of bone that enables cultivation of up to six tissue constructs simultaneously, with direct…”
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Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis by Lennon, Donald P., Edmison, John M., Caplan, Arnold I.

“…Rat mesenchymal stem cells (rMSCs) represent a small portion of the cells in the stromal compartment of bone marrow and have the potential to differentiate…”
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Author Accountability in Biomedical Research by Caplan, Arthur, Badylak, Stephen F, Caplan, Arnold I, Davies, Lindsay C, Strömblad, Staffan, Weiss, Daniel J, Le Blanc, Katarina

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Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds by Abrahamsson, Christoffer K, Yang, Fan, Park, Hyoungshin, Brunger, Jonathan M, Valonen, Piia K, Langer, Robert, Welter, Jean F, Caplan, Arnold I, Guilak, Farshid, Freed, Lisa E

“…Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering…”
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Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds by Solchaga, Luis A., Temenoff, Johnna S., Gao, Jizong, Mikos, Antonios G., Caplan, Arnold I., Goldberg, Victor M.

“…The natural repair of osteochondral defects can be enhanced with biocompatible, biodegradable materials that support the repair process. It is our hypothesis…”
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Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy by KOC, O. N, GERSON, S. L, COOPER, B. W, DYHOUSE, S. M, HAYNESWORTH, S. E, CAPLAN, A. I, LAZARUS, H. M

“…Multipotential mesenchymal stem cells (MSCs) are found in human bone marrow and are shown to secrete hematopoietic cytokines and support hematopoietic…”
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In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells by Johnstone, B, Hering, T M, Caplan, A I, Goldberg, V M, Yoo, J U

“…A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed. Cells…”
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Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54 by Lisignoli, Gina, Cristino, Sandra, Piacentini, Anna, Cavallo, Carola, Caplan, Arnold I., Facchini, Andrea

“…Hyaluronan (HA), in the bone marrow stroma, is the major non‐protein glycosaminoglycan component of extracellular matrix (ECM) involved in cell positioning,…”
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