Search Results - "Capitini, Christian M."

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies by Shankar, Keerthana, Capitini, Christian M, Saha, Krishanu

“…Abstract Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress…”
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GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models by Hess, Nicholas J, Brown, Matthew E, Capitini, Christian M

“…Graft- -host disease (GVHD) is the most common cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation (HSCT) despite…”
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Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer by Chapelin, Fanny, Capitini, Christian M, Ahrens, Eric T

“…Over the past two decades, immune cell therapy has emerged as a potent treatment for multiple cancers, first through groundbreaking leukemia therapy, and more…”
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Mesenchymal Stromal Cells and Exosomes: Progress and Challenges by Forsberg, Matthew H, Kink, John A, Hematti, Peiman, Capitini, Christian M

“…Due to their robust immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs) have been used as a cellular therapy for a number of human diseases…”
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Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer by Ayuso, Jose M., Farooqui, Mehtab, Virumbrales-Muñoz, María, Denecke, Katheryn, Rehman, Shujah, Schmitz, Rebecca, Guerrero, Jorge F., Sanchez-de-Diego, Cristina, Campo, Sara Abizanda, Maly, Elizabeth M., Forsberg, Matthew H., Kerr, Sheena C., Striker, Robert, Sherer, Nathan M., Harari, Paul M., Capitini, Christian M., Skala, Melissa C., Beebe, David J.

“…Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous…”
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Author Correction: Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer by Ayuso, Jose M., Farooqui, Mehtab, Virumbrales-Muñoz, María, Denecke, Katheryn, Rehman, Shujah, Schmitz, Rebecca, Guerrero, Jorge F., Sanchez-de-Diego, Cristina, Campo, Sara Abizanda, Maly, Elizabeth M., Forsberg, Matthew H., Kerr, Sheena C., Striker, Robert, Sherer, Nathan M., Harari, Paul M., Capitini, Christian M., Skala, Melissa C., Beebe, David J.

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Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease by Chinnadurai, Raghavan, Bates, Paul D, Kunugi, Keith A, Nickel, Kwangok P, DeWerd, Larry A, Capitini, Christian M, Galipeau, Jacques, Kimple, Randall J

“…Mesenchymal stromal cells (MSCs) are being tested as a cell therapy in clinical trials for dozens of inflammatory disorders, with varying levels of efficacy…”
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Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome by Kink, John A, Bellio, Michael A, Forsberg, Matthew H, Lobo, Alexandra, Thickens, Anna S, Lewis, Bryson M, Ong, Irene M, Khan, Aisha, Capitini, Christian M, Hematti, Peiman

“…Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility…”
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Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques by Weinfurter, Jason T., D’Souza, Saritha S., Matschke, Lea M., Bennett, Sarah, Kelnhofer-Millevolte, Laurel E., Suknuntha, Kran, Kumar, Akhilesh, Coonen, Jennifer, Capitini, Christian M., Hematti, Peiman, Golos, Thaddeus G., Slukvin, Igor I., Reynolds, Matthew R.

“…Allogeneic hematopoietic stem cell transplants (allo-HSCTs) dramatically reduce HIV reservoirs in antiretroviral therapy (ART) suppressed individuals. However,…”
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Exosomes from primed MSCs can educate monocytes as a cellular therapy for hematopoietic acute radiation syndrome by Forsberg, Matthew H, Kink, John A, Thickens, Anna S, Lewis, Bryson M, Childs, Charlie J, Hematti, Peiman, Capitini, Christian M

“…Acute radiation syndrome (ARS) is caused by acute exposure to ionizing radiation that damages multiple organ systems but especially the bone marrow (BM). We…”
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Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression by Mueller, Katherine P, Piscopo, Nicole J, Forsberg, Matthew H, Saraspe, Louise A, Das, Amritava, Russell, Brittany, Smerchansky, Madeline, Cappabianca, Dan, Shi, Lei, Shankar, Keerthana, Sarko, Lauren, Khajanchi, Namita, La Vonne Denne, Nina, Ramamurthy, Apoorva, Ali, Adeela, Lazzarotto, Cicera R, Tsai, Shengdar Q, Capitini, Christian M, Saha, Krishanu

“…BackgroundChimeric antigen receptor (CAR) T cells have demonstrated high clinical response rates against hematological malignancies (e.g., CD19+ cancers) but…”
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Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision by Emens, Leisha A, Romero, Pedro J, Anderson, Ana Carrizosa, Bruno, Tullia C, Capitini, Christian M, Collyar, Deborah, Gulley, James L, Hwu, Patrick, Posey, Avery D, Silk, Ann W, Wargo, Jennifer A

“…Cancer immunotherapy has flourished over the last 10–15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients…”
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Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence by Cappabianca, Dan, Pham, Dan, Forsberg, Matthew H., Bugel, Madison, Tommasi, Anna, Lauer, Anthony, Vidugiriene, Jolanta, Hrdlicka, Brookelyn, McHale, Alexandria, Sodji, Quaovi H., Skala, Melissa C., Capitini, Christian M., Saha, Krishanu

“…Manufacturing chimeric antigen receptor (CAR) T cell therapies is complex, with limited understanding of how medium composition impacts T cell phenotypes…”
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Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells by Cappabianca, Dan, Li, Jingling, Zheng, Yueting, Tran, Cac, Kasparek, Kassandra, Mendez, Pedro, Thu, Ricky, Maures, Travis, Capitini, Christian M, Deans, Robert, Saha, Krishanu

“…Efficient engineering of T cells to express exogenous tumor-targeting receptors such as chimeric antigen receptors (CARs) or T-cell receptors (TCRs) is a key…”
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An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo -Expanded Natural Killer Cells by Lieberman, Nicole A P, DeGolier, Kole, Haberthur, Kristen, Chinn, Harrison, Moyes, Kara W, Bouchlaka, Myriam N, Walker, Kirsti L, Capitini, Christian M, Crane, Courtney A

“…Recent advances in cellular therapies for patients with cancer, including checkpoint blockade and -expanded, tumor-specific T cells, have demonstrated that…”
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Combining Immunocytokine and Ex Vivo Activated NK Cells as a Platform for Enhancing Graft-Versus-Tumor Effects Against GD2 + Murine Neuroblastoma by Bates, Paul D, Rakhmilevich, Alexander L, Cho, Monica M, Bouchlaka, Myriam N, Rao, Seema L, Hales, Joanna M, Orentas, Rimas J, Fry, Terry J, Gilles, Stephen D, Sondel, Paul M, Capitini, Christian M

“…Management for high-risk neuroblastoma (NBL) has included autologous hematopoietic stem cell transplant (HSCT) and anti-GD2 immunotherapy, but survival remains…”
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Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD by Capitini, Christian M., Nasholm, Nicole M., Chien, Christopher D., Larabee, Shannon M., Qin, Haiying, Song, Young K., Klover, Peter J., Hennighausen, Lothar, Khan, Javed, Fry, Terry J.

“…Selective targeting of non-T cells, including antigen-presenting cells (APCs), is a potential strategy to prevent graft-versus-host-disease (GVHD) but to…”
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Hepatocellular Carcinoma Cells Are Protected From Immunolysis by Mesenchymal Stromal Cells Through Indoleamine 2,3 Dioxygenase by Chinnadurai, Raghavan, Porter, Amanda Paige, Patel, Mihir, Lipat, Ariel Joy, Forsberg, Mathews H., Rajan, Devi, Hematti, Peiman, Capitini, Christian M., Bruker, Charles

“…B7 family proteins serve as checkpoint molecules that protect tumors from T cell mediated lysis. Tryptophan degrading enzymes indoleamine 2,3 dioxygenase (IDO)…”
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Identification and Characterization of Two Bordetella avium Gene Products Required for Hemagglutination by Temple, Louise M, Miyamoto, David M, Mehta, Manju, Capitini, Christian M, Von Stetina, Stephen, Barnes, H. John, Christensen, Vern L, Horton, John R, Spears, Patricia A, Orndorff, Paul E

“…Bordetella avium causes bordetellosis in birds, a disease similar to whooping cough caused by Bordetella pertussis in children. B. avium agglutinates guinea…”
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Human Mesenchymal Stem Cell-Educated Macrophages are a Distinct High IL-6 Producing Subset That Confer Protection in Graft-Versus-Host-Disease and Radiation Injury Models by Bouchlaka, Myriam N., Ph.D, Moffitt, Andrea B., Ph.D, Kim, Jaehyup, M.D., Ph.D, Kink, John A., Ph.D, Bloom, Debra D., Ph.D, Love, Cassandra, Dave, Sandeep, M.D., M.S, Hematti, Peiman, M.D, Capitini, Christian M., M.D

“…Highlights • MSC-educated macrophages (MEMs) are an alternatively activated macrophage subset • MEMs secrete high levels of IL-6 controlled in part by…”
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