Search Results - "Capella, G"

Recent advances in cancer therapy: an overview by Urruticoechea, A, Alemany, R, Balart, J, Villanueva, A, Viñals, F, Capellá, G

“…The landscape of cancer treatment has dramatically changed over the last four decades. The age when surgery and radiotherapy were the only effective way to…”
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Guidelines for the clinical management of familial adenomatous polyposis (FAP) by Vasen, H F A, Möslein, G, Alonso, A, Aretz, S, Bernstein, I, Bertario, L, Blanco, I, Bülow, S, Burn, J, Capella, G, Colas, C, Engel, C, Frayling, I, Friedl, W, Hes, F J, Hodgson, S, Järvinen, H, Mecklin, J-P, Møller, P, Myrhøi, T, Nagengast, F M, Parc, Y, Phillips, R, Clark, S K, de Leon, M Ponz, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Tejpar, S, Thomas, H J W, Wijnen, J

“…Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is…”
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Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer by Fernández-Rozadilla, C., Álvarez-Barona, M., Quintana, I., López-Novo, A., Amigo, J., Cameselle-Teijeiro, J. M., Roman, E., Gonzalez, D., Llor, X., Bujanda, L., Bessa, X., Jover, R., Balaguer, F., Castells, A., Castellví-Bel, S., Capellá, G., Carracedo, A., Valle, L., Ruiz-Ponte, Clara

“…Colorectal cancer (CRC) is a complex disease that can be caused by a spectrum of genetic variants ranging from low to high penetrance changes, that interact…”
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Peutz-Jeghers syndrome: a systematic review and recommendations for management by Beggs, A D, Latchford, A R, Vasen, H F A, Moslein, G, Alonso, A, Aretz, S, Bertario, L, Blanco, I, Bülow, S, Burn, J, Capella, G, Colas, C, Friedl, W, Møller, P, Hes, F J, Järvinen, H, Mecklin, J-P, Nagengast, F M, Parc, Y, Phillips, R K S, Hyer, W, Ponz de Leon, M, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Tejpar, S, Thomas, H J W, Wijnen, J T, Clark, S K, Hodgson, S V

“…Peutz-Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal…”
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Phase II study of high-sensitivity genotyping of KRAS, NRAS, BRAF and PIK3CA to ultra-select metastatic colorectal cancer patients for panitumumab plus FOLFIRI: the ULTRA trial by Santos, C., Azuara, D., Viéitez, J.M., Páez, D., Falcó, E., Élez, E., López-López, C., Valladares, M., Robles-Díaz, L., García-Alfonso, P., Bugés, C., Durán, G., Salud, A., Navarro, V., Capellá, G., Aranda, E., Salazar, R.

“…Several studies show the importance of accurately quantifying not only KRAS and other low-abundant mutations because benefits of anti-EGFR therapies may depend…”
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Ultra-selection of metastatic colorectal cancer patients using next-generation sequencing to improve clinical efficacy of anti-EGFR therapy by Vidal, J., Bellosillo, B., Santos Vivas, C., García-Alfonso, P., Carrato, A., Cano, M.T., García-Carbonero, R., Élez, E., Losa, F., Massutí, B., Valladares-Ayerbes, M., Viéitez, J.M., Manzano, J.L., Azuara, D., Gallego, J., Pairet, S., Capellá, G., Salazar, R., Tabernero, J., Aranda, E., Montagut, C.

“…Extended RAS analysis is mandatory in metastatic colorectal cancer (mCRC) patients. The optimal threshold of RAS mutated subclones to identify patients most…”
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Helicobacter pylori cagA and vacA Genotypes as Predictors of Progression of Gastric Preneoplastic Lesions: A Long-Term Follow-Up in a High-Risk Area in Spain by GONZALEZ, Carlos A, FIGUEIREDO, Ceu, BONET, C, FERREIRA, R. M, PARDO, M. L, RUIZ LISO, J. M, ALONSO, P, SALA, N, CAPELLA, G, SANZ-ANQUELA, J. M

“…There are no established predictive markers of progression of gastric preneoplastic lesions. The aim of this study was to analyze the relationship between…”
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Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer) by Vasen, H F A, Möslein, G, Alonso, A, Bernstein, I, Bertario, L, Blanco, I, Burn, J, Capella, G, Engel, C, Frayling, I, Friedl, W, Hes, F J, Hodgson, S, Mecklin, J-P, Møller, P, Nagengast, F, Parc, Y, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Wijnen, J

“…Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the development of colorectal cancer, endometrial cancer and various other…”
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Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST) by Crusius, J.B.A., Canzian, F., Capellá, G., Peña, A.S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H.B., Carneiro, F., Pala, V., Save, V.E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martínez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quirós, J.R., Allen, N., Key, T.J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjønneland, A., Büchner, F.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., González, C.A.

“…The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from…”
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Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study by Rivera, B., González, S., Sánchez-Tomé, E., Blanco, I., Mercadillo, F., Letón, R., Benítez, J., Robledo, M., Capellá, G., Urioste, M.

“…Classical familial adenomatous polyposis (FAP) is characterized by the appearance of >100 colorectal adenomas. We screened the APC and MUTYH genes for…”
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Identification of a founder BRCA1 mutation in the Moroccan population by Quiles, F., Teulé, À., Martinussen Tandstad, N., Feliubadaló, L., Tornero, E., del Valle, J., Menéndez, M., Salinas, M., Wethe Rognlien, V., Velasco, A., Izquierdo, A., Capellá, G., Brunet, J., Lázaro, C.

“…Breast cancer (BC) is the most frequent cancer among women in Morocco. However, the role of the most prevalent BC‐predisposing genes, BRCA1 and BRCA2, has been…”
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Antihelminthic action of the Anethum graveolens essential oil on Haemonchus contortus eggs and larvae by Castro, L M, Pinto, N B, Moura, M Q, Villela, M M, Capella, G A, Freitag, R A, Berne, M E A

“…Gastrointestinal nematodes are responsible for great economic losses in sheep raising, and their control has long been carried out almost exclusively by the…”
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Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer by Fernández-Majada, V, Aguilera, C, Villanueva, A, Vilardell, F, Robert-Moreno, A, Aytés, A, Real, F.X, Capella, G, Mayo, M.W, Espinosa, L, Bigas, A

“…Nuclear functions for IκB kinase (IKK), including phosphorylation of histone H3 and nuclear corepressors, have been recently described. Here, we show that IKK…”
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Are women with pathogenic variants in PMS2 and MSH6 really at high lifetime risk of breast cancer? by Evans, D. G., Woodward, E. R., Lalloo, F., Møller, P., Sampson, J., Burn, J., Moeslein, G., Capella, G.

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K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression by GUERRERO, Silvia, CASANOVA, Isolda, FARRE, Lourdes, MAZO, Adela, CAPELLA, Gabriel, MANGUES, Ramon

“…The position of the point mutation in the c-K-ras gene appears associated with different degrees of aggressiveness in human colorectal tumors. In addition,…”
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Detailed characterization of MLH1 p.D41H and p.N710D variants coexisting in a Lynch syndrome family with conserved MLH1 expression tumors by Pineda, M., González-Acosta, M., Thompson, B.A., Sánchez, R., Gómez, C., Martínez-López, J., Perea, J., Caldés, T., Rodríguez, Y., Landolfi, S., Balmaña, J., Lázaro, C., Robles, L., Capellá, G., Rueda, D.

“…Lynch syndrome (LS) is an autosomal dominant cancer‐susceptibility disease caused by inactivating germline mutations in mismatch repair (MMR) genes. Variants…”
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Identification of a founder EPCAM deletion in Spanish Lynch syndrome families by Mur, P., Pineda, M., Romero, A., del Valle, J., Borràs, E., Canal, A., Navarro, M., Brunet, J., Rueda, D., Ramón y Cajal, T., Lázaro, C., Caldés, T., Blanco, I., Soto, J.L., Capellá, G.

“…Germline deletions at the 3′‐end of EPCAM have been involved in the etiology of Lynch syndrome (LS). The aim of this study was to characterize at the molecular…”
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Recommendations to improve identification of hereditary and familial colorectal cancer in Europe by Vasen, H. F. A., Möslein, G., Alonso, A., Aretz, S., Bernstein, I., Bertario, L., Blanco, I., Bulow, S., Burn, J., Capella, G., Colas, C., Engel, C., Frayling, I., Rahner, N., Hes, F. J., Hodgson, S., Mecklin, J.-P., Møller, P., Myrhøj, T., Nagengast, F. M., Parc, Y., Ponz de Leon, M., Renkonen-Sinisalo, L., Sampson, J. R., Stormorken, A., Tejpar, S., Thomas, H. J. W., Wijnen, J., Lubinski, J., Järvinen, H., Claes, E., Heinimann, K., Karagiannis, J. A., Lindblom, A., Dove-Edwin, I., Müller, H.

“…Familial colorectal cancer (CRC) accounts for 10–15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited…”
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DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study by Capellá, Gabriel, Pera, Guillem, Sala, Núria, Agudo, Antonio, Rico, Francisco, Del Giudicce, Giuseppe, Plebani, Mario, Palli, Domenico, Boeing, Heiner, Bueno-de-Mesquita, H Bas, Carneiro, Fátima, Berrino, Franco, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Nyrén, Olof, Hallmans, Goran, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R, Allen, Naomi, Key, Tim, Bingham, Sheila, Caldas, Carlos, Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Tjonneland, Anne, Boshuizen, Hendriek C, Peeters, Petra HM, Numans, Mattijs E, Clavel-Chapelon, Françoise, Trichopoulou, Antonia, Lund, Eiliv, Jenab, Mazda, Kaaks, Rudolf, Riboli, Elio, González, Carlos A

“…Background The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown. The aim of this study was to…”
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First-in-human dose-escalation study of VCN-01, a selective oncolytic adenovirus with hyaluronidase activity in patients with advanced or metastatic cancer by Hidalgo, M, Gil, M, Garcia-Carbonero, R, Alvarez, R, Laquente, B, Moreno, R, De Martino, A, Alemany, R, Capella, G, Blasi, E, Viaplana, I, Cascallo, M, Salazar, R

“…Background: VCN-01 is a selective oncolytic adenovirus with hyaluronid-ase activity. This study aimed to determine the safety, pharmacokinetics (PK) and…”
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