Search Results - "Capdevila, J.H."

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension by Capdevila, J.H., Falck, J.R., Imig, J.D.

“…Studies of the cytochrome P450 arachidonic acid (AA) monooxygenase, now established as a major pathway for the bioactivation of this physiological important…”
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Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform by Zeldin, D.C., Dubois, R.N., Falck, J.R., Capdevila, J.H.

“…A cDNA containing an open reading frame coding for a human cytochrome P450 arachidonic acid epoxygenase was isolated from a male human kidney cDNA library…”
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Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase by ZELDIN, D. C, KOBAYASHI, J, FALCK, J. R, WINDER, B. S, HAMMOCK, B. D, SNAPPER, J. R, CAPDEVILA, J. H

“…The hydration of cis-epoxyeicosatrienoic acids to the corresponding vic-dihydroxyeicosatrienoic acids by cytosolic epoxide hydrolase demonstrates moderate…”
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Metabolism of Epoxyeicosatrienoic Acids by Cytosolic Epoxide Hydrolase: Substrate Structural Determinants of Asymmetric Catalysis by Zeldin, D.C., Wei, S.Z., Falck, J.R., Hammock, B.D., Snapper, J.R., Capdevila, J.H.

“…The metabolism of cis-epoxyeicosatrienoic acids (EETs), methyl cis-epoxyeicosatrienoates, and cis-epoxyeicosanoic acids by cytosolic epoxide hydrolase was…”
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Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver by RIFKIND, A. B, KANETOSHI, A, ORLINICK, J, CAPDEVILA, J. H, LEE, C

“…Two cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in chick embryo liver microsomes were purified. The P-450s exhibit…”
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Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading by Capdevila, J.H., Wei, S, Yan, J, Karara, A, Jacobson, H.R., Falck, J.R., Guengerich, F.P., DuBois, R.N.

“…The rat kidney microsomal epoxygenase catalyzed the asymmetric epoxidation of arachidonic acid to generate as major products: 8(R),9(S)-, 11(R),12(S)- and…”
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Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase by KARARA, A, MAKITA, K, JACOBSON, H. R, FALCK, J. R, GUENGERICH, F. P, DUBOIS, R. N, CAPDEVILA, J. H

“…A cDNA containing an open reading frame coding for the rat kidney cytochrome P-450 arachidonic acid epoxygenase was isolated from a male rat kidney cDNA…”
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Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase by Capdevila, J.H, Falck, J.R, Harris, R.C

“…The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and omega/omega-1 hydroxylase as…”
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Microsomal cytochrome P450 and eicosanoid metabolism by Capdevila, J H, Harris, R C, Falck, J R

“…The demonstration of a role for microsomal P450 in the metabolism of endogenous pools of arachidonic acid established this enzyme system as a member of the…”
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Does Malfunction of Arachidonic Acid Epoxygenase Explain Salt-Sensitive Hypertension?: Salt-Sensitive Hypertension Is Associated with Dysfunctional Cyp4a10 Gene and Kidney Epithelial Sodium Channel. J Clin Invest 116: 1696-1702, 2006 by Nakagawa, K, Holla, V R, Wei, Y, Wang, W H, Gatica, A, Wei, S, Mei, S, Miller, C M, Cha, D R, Price, Jr, E, Zent, R, Pozzi, A, Breyer, M D, Guan, Y, Falck, J R, Waterman, M R, Capdevila, J H

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7-HETE, 10-HETE, and 13-HETE Are Major Products of NADPH-Dependent Arachidonic Acid Metabolism in Rat Liver Microsomes: Analysis of Their Stereochemistry, and the Stereochemistry of Their Acid-Catalyzed Rearrangement by Brash, A.R., Boeglin, W.E., Capdevila, J.H., Yeola, S., Blair, I.A.

“…A complex profile of metabolites of [ 14C]arachidonic acid are formed in NADPH-dependent reactions in liver microsomes from phenobarbital-treated rats. The…”
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Biochemical and functional properties of the P450 arachidonic acid monooxygenase by Capdevila, J.H., Holla, V., owart, A., Helvig, C.

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Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid by Lapuerta, L, Chacos, N, Falck, J R, Jacobson, H, Capdevila, J H

“…Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols…”
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