Search Results - "Caparon, Michael G."

Central carbon flux controls growth/damage balance for Streptococcus pyogenes by Merriman, Joseph A, Xu, Wei, Caparon, Michael G

“…Microbial pathogens balance growth against tissue damage to achieve maximum fitness. Central carbon metabolism is connected to growth, but how it influences…”
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Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F₁Fₒ-ATPase by Cusumano, Zachary T, Caparon, Michael G

“…A common stress encountered by both pathogenic and environmental bacteria is exposure to a low-pH environment, which can inhibit cell growth and lead to cell…”
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Microbial co-occurrences on catheters from long-term catheterized patients by Nye, Taylor M., Zou, Zongsen, Obernuefemann, Chloe L. P., Pinkner, Jerome S., Lowry, Erin, Kleinschmidt, Kent, Bergeron, Karla, Klim, Aleksandra, Dodson, Karen W., Flores-Mireles, Ana L., Walker, Jennifer N., Wong, Daniel Garrett, Desai, Alana, Caparon, Michael G., Hultgren, Scott J.

“…Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are…”
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A tale of two pili: assembly and function of pili in bacteria by Kline, Kimberly A, Dodson, Karen W, Caparon, Michael G, Hultgren, Scott J

“…Bacterial pili have long been recognized as mediators of initial host–pathogen interactions important for the progression of Gram-negative bacterial diseases…”
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Streptococcus pyogenes malate degradation pathway links pH regulation and virulence by Paluscio, Elyse, Caparon, Michael G

“…The ability of Streptococcus pyogenes to infect different niches within its human host most likely relies on its ability to utilize alternative carbon sources…”
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Dual modes of membrane binding direct pore formation by Streptolysin O by Mozola, Cara C., Caparon, Michael G.

“…Summary Effector translocation is central to the virulence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the…”
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The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis by Chandrasekaran, Sukantha, Caparon, Michael G

“…Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two…”
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Enterococcal Biofilm Formation and Virulence in an Optimized Murine Model of Foreign Body-Associated Urinary Tract Infections by Guiton, Pascale S, Hung, Chia S, Hancock, Lynn E, Caparon, Michael G, Hultgren, Scott J

“…Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial UTIs and pose significant clinical challenges. Enterococcal species…”
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Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI by Molina, Jonathan J., Kohler, Kurt N., Gager, Christopher, Andersen, Marissa J., Wongso, Ellsa, Lucas, Elizabeth R., Paik, Andrew, Xu, Wei, Donahue, Deborah L., Bergeron, Karla, Klim, Aleksandra, Caparon, Michael G., Hultgren, Scott J., Desai, Alana, Ploplis, Victoria A., Flick, Matthew J., Castellino, Francis J., Flores-Mireles, Ana L.

“…Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to…”
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Streptococcus pyogenes Arginine and Citrulline Catabolism Promotes Infection and Modulates Innate Immunity by Cusumano, Zachary T, Watson, Jr, Michael E, Caparon, Michael G

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Enterococcus faecalis Overcomes Foreign Body-Mediated Inflammation To Establish Urinary Tract Infections by Guiton, Pascale S, Hannan, Thomas J, Ford, Bradley, Caparon, Michael G, Hultgren, Scott J

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CcpA and LacD.1 Affect Temporal Regulation of Streptococcus pyogenes Virulence Genes by Kietzman, Colin C, Caparon, Michael G

“…Production of H₂O₂ follows a growth phase-dependent pattern that mimics that of many virulence factors of Streptococcus pyogenes. To gain greater insight into…”
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Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice by GUITON, Pascale S, CUSUMANO, Corinne K, KLINE, Kimberly A, DODSON, Karen W, ZHENFU HAN, JANETKA, James W, HENDERSON, Jeffrey P, CAPARON, Michael G, HULTGREN, Scott J

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Virulence Gene Regulation by CvfA, a Putative RNase: the CvfA-Enolase Complex in Streptococcus pyogenes Links Nutritional Stress, Growth-Phase Control, and Virulence Gene Expression by Kang, Song Ok, Caparon, Michael G, Cho, Kyu Hong

“…Streptococcus pyogenes, a multiple-auxotrophic human pathogen, regulates virulence gene expression according to nutritional availability during various stages…”
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Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis by Kandaswamy, Kumaravel, Liew, Tze Horng, Wang, Charles Y., Huston-Warren, Emily, Meyer-Hoffert, Ulf, Hultenby, Kjell, Schröder, Jens M., Caparon, Michael G., Normark, Staffan, Henriques-Normark, Birgitta, Hultgren, Scott J., Kline, Kimberly A.

“…Virulence factor secretion and assembly occurs at spatially restricted foci in some Gram-positive bacteria. Given the essentiality of the general secretion…”
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Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes by Cho, Kyu Hong, Caparon, Michael G.

“…Summary The ability of Streptococcus pyogenes to form biofilm‐like bacterial communities during infection of soft tissue has suggested that the capacity to…”
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Contribution of Autolysin and Sortase A during Enterococcus faecalis DNA-Dependent Biofilm Development by Guiton, Pascale S, Hung, Chia S, Kline, Kimberly A, Roth, Robyn, Kau, Andrew L, Hayes, Ericka, Heuser, John, Dodson, Karen W, Caparon, Michael G, Hultgren, Scott J

“…Biofilm production is a major attribute of Enterococcus faecalis clinical isolates. Although some factors, such as sortases, autolysin, and extracellular DNA…”
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A novel cholesterol‐insensitive mode of membrane binding promotes cytolysin‐mediated translocation by Streptolysin O by Mozola, Cara C., Magassa, N'Goundo, Caparon, Michael G.

“…Summary Cytolysin‐mediated translocation (CMT), performed by Streptococcus pyogenes, utilizes the cholesterol‐dependent cytolysin Streptolysin O (SLO) to…”
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Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections by Flores-Mireles, Ana L, Walker, Jennifer N, Potretzke, Aaron, Schreiber, 4th, Henry L, Pinkner, Jerome S, Bauman, Tyler M, Park, Alyssa M, Desai, Alana, Hultgren, Scott J, Caparon, Michael G

“…Gram-positive bacteria in the genus Enterococcus are a frequent cause of catheter-associated urinary tract infection (CAUTI), a disease whose treatment is…”
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Pilin and Sortase Residues Critical for Endocarditis- and Biofilm-Associated Pilus Biogenesis in Enterococcus faecalis by Nielsen, Hailyn V, Flores-Mireles, Ana L, Kau, Andrew L, Kline, Kimberly A, Pinkner, Jerome S, Neiers, Fabrice, Normark, Staffan, Henriques-Normark, Birgitta, Caparon, Michael G, Hultgren, Scott J

“…Enterococci commonly cause hospital-acquired infections, such as infective endocarditis and catheter-associated urinary tract infections. In animal models of…”
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