Search Results - "Caparco, Adam"

Protein Mediated Enzyme Immobilization by Caparco, Adam A., Dautel, Dylan R., Champion, Julie A.

“…Enzyme immobilization is an essential technology for commercializing biocatalysis. It imparts stability, recoverability, and other valuable features that…”
Get full text

Metagenomic Mining for Amine Dehydrogenase Discovery by Caparco, Adam A., Pelletier, Eric, Petit, Jean Louis, Jouenne, Aurélie, Bommarius, Bettina R., Berardinis, Véronique, Zaparucha, Anne, Champion, Julie A., Bommarius, Andreas S., Vergne‐Vaxelaire, Carine

“…Amine dehydrogenases (AmDHs) catalyze the enzymatic reduction of ketones to amines, serving as a suitable biocatalytic route for amine synthesis. A limited…”
Get full text

Poly(Oxanorbornene)‐Protein Conjugates Prepared by Grafting‐to ROMP as Alternatives for PEG by Davis, Elizabathe, Caparco, Adam A., Steinmetz, Nicole F., Pokorski, Jonathan K.

“…PEGylation is the gold standard in protein‐polymer conjugation, improving circulation half‐life of biologics while mitigating the immune response to a foreign…”
Get full text

Delivery of Nematicides Using TMGMV-Derived Spherical Nanoparticles by Caparco, Adam A., González-Gamboa, Ivonne, Hays, Samuel S., Pokorski, Jonathan K., Steinmetz, Nicole F.

“…Spherical nanoparticles (SNPs) from tobacco mild green mosaic virus (TMGMV) were developed and characterized, and their application for agrochemical delivery…”
Get full text

Protein‐inorganic calcium‐phosphate supraparticles as a robust platform for enzyme co‐immobilization by Caparco, Adam A., Bommarius, Bettina R., Bommarius, Andreas S., Champion, Julie A.

“…Immobilization of enzymes provides many benefits, including facile separation and recovery of enzymes from reaction mixtures, enhanced stability, and…”
Get full text

Effect of peptide linker length and composition on immobilization and catalysis of leucine zipper‐enzyme fusion proteins by Caparco, Adam A., Bommarius, Andreas S., Champion, Julie A.

“…Linkers are critical components of fusion proteins, as they physically separate individual domains to enable each to fold and retain function. The role of…”
Get full text

Inter-coat protein loading of active ingredients into Tobacco mild green mosaic virus through partial dissociation and reassembly of the virion by González-Gamboa, Ivonne, Caparco, Adam A., McCaskill, Justin, Fuenlabrada-Velázquez, Paulina, Hays, Samuel S., Jin, Zhicheng, Jokerst, Jesse V., Pokorski, Jonathan K., Steinmetz, Nicole F.

“…Chemical pesticide delivery is a fundamental aspect of agriculture. However, the extensive use of pesticides severely endangers the ecosystem because they…”
Get full text

Tuning the Morphology of Protein–Inorganic Calcium–Phosphate Supraparticles via Directed Assembly by Caparco, Adam A, Wang, Melanee, Das, Ankita, Bommarius, Andreas S, Champion, Julie A

“…Understanding the phenomena that govern complex interfacial and directed assemblies is essential for both control and scale-up of particle syntheses. The…”
Get full text

DNA Delivery by Virus-Like Nanocarriers in Plant Cells by Islam, Md Reyazul, Youngblood, Marina, Kim, Hye-In, González-Gamboa, Ivonne, Monroy-Borrego, Andrea Gabriela, Caparco, Adam A., Lowry, Gregory V., Steinmetz, Nicole F., Giraldo, Juan Pablo

“…Tobacco mild green mosaic virus (TMGMV)-like nanocarriers were designed for gene delivery to plant cells. High aspect ratio TMGMVs were coated with a…”
Get full text

Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus by González‐Gamboa, Ivonne, Caparco, Adam A., McCaskill, Justin M., Steinmetz, Nicole F.

“…Tobacco mild green mosaic virus (TMGMV) is a plant virus closely related to Tobacco mosaic virus (TMV), sharing many of its structural and chemical features…”
Get full text

Combination of cowpea mosaic virus (CPMV) intratumoral therapy and oxaliplatin chemotherapy by Moreno-Gonzalez, Miguel A, Zhao, Zhongchao, Caparco, Adam A, Steinmetz, Nicole F

“…Cowpea mosaic virus is a potent intratumoral immunotherapy agent that has shown promise in preclinical studies and canine cancer trials with tumor- and…”
Get full text

Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity by Church, Derek C., Davis, Elizabathe, Caparco, Adam A., Takiguchi, Lauren, Chung, Young Hun, Steinmetz, Nicole F., Pokorski, Jonathan K.

“…Protein-polymer conjugates (PPCs) improve therapeutic efficacy of proteins and have been widely used for the treatment of various diseases such as cancer,…”
Get full text

Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols by Ducrot, Laurine, Bennett, Megan, Caparco, Adam A., Champion, Julie A., Bommarius, Andreas S., Zaparucha, Anne, Grogan, Gideon, Vergne-Vaxelaire, Carine

“…Small optically active molecules, and more particularly short-chain chiral amines, are key compounds in the chemical industry and precursors of various…”
Get full text

Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase by Franklin, Robert D., Whitley, Joshua A., Caparco, Adam A., Bommarius, Bettina R., Champion, Julie A., Bommarius, Andreas S.

“…•IMAC resin immobilization yielded 6.5 d half life and ≤443 g/(L∙d) productivity.•Overall reaction rate is limited by excess enzyme over cofactor but not mass…”
Get full text

Towards realizing nano-enabled precision delivery in plants by Lowry, Gregory V., Giraldo, Juan Pablo, Steinmetz, Nicole F., Avellan, Astrid, Demirer, Gozde S., Ristroph, Kurt D., Wang, Gerald J., Hendren, Christine O., Alabi, Christopher A., Caparco, Adam, da Silva, Washington, González-Gamboa, Ivonne, Grieger, Khara D., Jeon, Su-Ji, Khodakovskaya, Mariya V., Kohay, Hagay, Kumar, Vivek, Muthuramalingam, Raja, Poffenbarger, Hanna, Santra, Swadeshmukul, Tilton, Robert D., White, Jason C.

“…Nanocarriers (NCs) that can precisely deliver active agents, nutrients and genetic materials into plants will make crop agriculture more resilient to climate…”
Get full text

Plant Viral Nanocarrier Soil Mobility as a Function of Soil Type and Nanoparticle Properties by Venkateswaran, Udhaya Pooranam, Caparco, Adam A., González-Gamboa, Ivonne, Caballero, Reca Marian, Schuphan, Juliane, Steinmetz, Nicole F.

“…The use of nanoparticles for agrochemical delivery is an important step toward achieving global food security. Specifically, the ability to target the delivery…”
Get full text