Search Results - "Cao, Zhisong"

Crystalline Camptothecin-20(S)-O-Propionate Hydrate: A Novel Anticancer Agent with Strong Activity against 19 Human Tumor Xenografts by ZHISONG CAO, KOZIELSKI, Anthony, XING LIU, YANG WANG, VARDEMAN, Dana, GIOVANELLA, Beppino

“…To find a more effective and less toxic chemotherapeutic agent, we have successfully prepared crystalline camptothecin-20(S)-O-propionate hydrate (CZ48) by…”
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Metabolic difference of CZ48 in human and mouse liver microsomes by Liu, Xing, Dejesus, Albert, Cao, Zhisong, Vardeman, Dana, Giovanella, Beppino

“…CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation…”
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Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma by Liu, Xing, Wang, Yang, Vardeman, Dana, Cao, Zhisong, Giovanella, Beppino

“…A simple and sensitive high-performance liquid chromatography (HPLC) assay for the analysis of CZ48, a potent anticancer candidate, and its active metabolite…”
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Enhanced lactone stability of CZ48 in blood correlates to its lack of toxicity in mice by Liu, Xing, Wang, Yang, Cao, Zhisong, Zhan, Max, Vardeman, Dana, Giovanella, Beppino

“…The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48,…”
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Anticancer activity of new haloalkyl camptothecin esters against human cancer cell lines and human tumor xenografts grown in nude mice by Cao, Zhisong, Mendoza, John, Kozielski, Anthony, Liu, Xing, Dejesus, Albert, Wang, Yang, Zhan, Chang-Guo, Vardeman, Dana, Giovanella, Beppino

“…All chemotherapeutic agents currently in use have a narrow window of therapeutic index of 1 to 1.2. Camptothecin ester compounds are reported to have a wider…”
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Explainable deep learning for automatic rock classification by Zheng, Dongyu, Zhong, Hanting, Camps-Valls, Gustau, Cao, Zhisong, Ma, Xiaogang, Mills, Benjamin, Hu, Xiumian, Hou, Mingcai, Ma, Chao

“…As deep learning (DL) gains popularity for its ability to make accurate predictions in various fields, its applications in geosciences are also on the rise…”
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Effect of Nonstationarity on Shear Properties of Rock Joints and a New Peak Shear Strength Criterion by Zhang, Xiaobo, Cao, Zhisong, Yao, Chi, Yang, Jianhua, Ma, Yongli, Ye, Zhiwei, Zhou, Chuangbing

“…In rock masses, there might be structural nonstationarity in the joint morphology that influences the shear behavior of rock joints. However, research into…”
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The development and validation of an LC-MS/MS method for the quantification of CZ112, a prodrug of 9-Nitrocamptothecin in rat plasma by Wang, Ziming, Shao, Changmin, Hu, Zhiwei, Zheng, Jian, Zhang, Qiang, Kou, Xiaohan, Wang, Zijia, Yu, Tao, Cao, Zhisong, Wang, Yang

“…[Display omitted] •9-Nitrocamptothecin was identified as the major metabolite of CZ112, a prodrug of 9-nitrocamptothecin, in rat plasma.•An LC–MS/MS method for…”
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The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs) by Zheng, Jian, Chan, Ting, Zhu, Ling, Yan, Xiufeng, Cao, Zhisong, Wang, Yang, Zhou, Fanfan

“…1. Camptothecin (CPT) and its derivatives are potent candidate compounds in treating cancers. However, their clinical applications are largely restricted by…”
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Abstract 4337: In vitro biotransformation of and inhibitory effects of CZ48 in human liver microsomes by Liu, Xing, DeJesus, Albert, Vardeman, Dana, Cao, Zhisong, Giovanella, Beppino

“…BACKGROUND AND PURPOSE CZ48 is a novel potent anticancer agent currently in a phase I clinical trial. The absorption of CZ48 in humans is approximately less…”
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NO adsorption study on the distribution of Ni2 + ions on the various micro-environments of carriers by Niu Guoxing, Huang, Yao, Cao Zhisong, Huang, Yufang, Li, Quanzhi

“…The decrease of the electron density in the d orbits of Ni2 + ions, resulting from the disturbance of micro-environments in which Ni2+ ions are located, makes…”
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Reactions of azines. 16. Preparation of 6-(phenylmethylene)-5H-pyrazolo[1,5-d][2,4]benzoxazepines, 5H,7H-pyrazolo[1,5-d][2]benzazepin-6-one, and indeno[2,3-c]pyridine-3,9-diones by Schweizer, Edward E, Cao, Zhisong, Rheingold, Arnold L, Bruch, Martha

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NO adsorption study on the distribution of nickel ions on the mixed carriers of USY zeolite and γ-Al2O3 by Niu, Guoxing, Huang, Yao, Cao, Zhisong, Huang, Yufang, Li, Quanzhi

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Abstract 5658: Development and optimization of CZ48-loaded microbubbles for controlled drug delivery by Wang, Yang, Li, Siyang, Zheng, Jian, Yan, Xiufeng, Cao, Zhisong, Vardeman, Dana, Giovanella, Beppino

“…CZ48, the 20-O-propionate ester of camptothecin, is a prodrug requiring activation by converting to parental CPT in vivo. To circumvent the problems of low…”
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Abstract 3547: The differences in intestinal absorptions between CZ48 and its parental Camptothecin by Liu, Xing, DeJesus, Albert, Cao, Zhisong, Giovanella, Beppino

“…The determination of oral bioavailability is a critical step in early phase drug development. In part, the ability to predict whether a drug will be…”
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A first-in-human phase I study of CZ48, a lactone ring protected oral camptothecin, in patients with advanced solid tumors by Mahalingam, Devalingam, Shaheen, Montaser F., Sarantopoulos, John, Weitman, Steven, Giovanella, Beppino C., Cao, Zhisong, Coil, Douglas, Markides, Constantine, Liu, Lucy, Verschraegen, Claire F.

“…Abstract only 2578 Background: CZ48, the 20-O-propionate ester of camptothecin (CPT), is a prodrug of CPT first described by Cao et al. in 1998. The side-chain…”
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Reactions of azines. 15. Preparation of pyrazolo[1,5-c][1,3]oxazepin-6-ones by Schweizer, Edward E, Cao, Zhisong, Rheingold, Arnold, Bruch, Martha

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Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors by LIU, XING, CAO, ZHISONG, MENDOZA, JOHN, VARDEMAN, DANA, GIOVANELLA, BEPPINO

“…Crystalline camptothecin-20-O-propionate hydrate (CZ48) is an esterification product from the reaction of natural camptothecin with propionic anhydride. CZ48…”
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Synthesis and antitumor activity of aromatic camptothecin esters by Cao, Zhisong, Mendoza, John, DeJesus, Albert, Vardeman, Dana, Giovanella, Beppino

“…Twenty-eight new aromatic esters of camptothecins 2-29 were prepared in yields of 5 to 96% by straight acylation of camptothecin (1a) and 9-nitrocamptothecin…”
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Alkyl Esters of Camptothecin and 9-Nitrocamptothecin:  Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity by Cao, Zhisong, Harris, Nick, Kozielski, Anthony, Vardeman, Dana, Stehlin, John S, Giovanella, Beppino

“…Eleven camptothecin esters, 6a−e and 7a−f, were prepared by straightforward acylation of camptothecins with the corresponding acylating reagents such as…”
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