Search Results - "Cao, Zhengyu"
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Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
Published in Nature communications (14-04-2020)“…B cell dysfunction due to obesity can be associated with alterations in the levels of micro-RNAs (miRNAs). However, the role of miRNAs in these processes…”
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2
TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways
Published in Cell biology and toxicology (01-04-2021)“…Transient receptor potential vanilloid 3 (TRPV3) is highly expressed in skin keratinocytes where it forms Ca 2+ -permeable nonselective cation channels to…”
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3
DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1
Published in Cell death & disease (20-01-2024)“…The circadian-controlled DNA repair exhibits a strong diurnal rhythm. Disruption in circadian clock and DNA repair is closely linked with hepatocellular…”
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4
Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
Published in eLife (20-04-2021)“…The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus,…”
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5
Identification and Characterization of a Novel Soluble Pyridine Nucleotide Transhydrogenase from Streptomyces avermitilis
Published in Current microbiology (01-01-2022)“…Soluble pyridine nucleotide transhydrogenase (STH) transfers hydride between NADH and NADPH to maintain redox balance. In the present study, the sth gene from…”
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6
Cardiotoxicity screening: a review of rapid-throughput in vitro approaches
Published in Archives of toxicology (01-08-2016)“…Cardiac toxicity represents one of the leading causes of drug failure along different stages of drug development. Multiple very successful pharmaceuticals had…”
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The protective effects of Ribes diacanthum Pall on cisplatin-induced nephrotoxicity in mice
Published in Journal of ethnopharmacology (03-02-2016)“…Ribes diacanthum Pall. (Saxifragaceae), a Mongolian folk medicinal plant, was used to treat urinary system diseases. The present work aims to investigate the…”
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8
Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption
Published in Frontiers in pharmacology (21-10-2024)“…Introduction Scutellarein (Scu) is a natural occurring flavonoid found in multiple traditional Chinese medicines such as Oroxylum indicum (L.) Kurz and…”
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9
An in vivo mouse model of primary dysmenorrhea
Published in Experimental Animals (01-01-2015)“…Primary dysmenorrhea (PD) is a common gynecological disorder. Hitherto, animal models which recapitulate clinical features of PD have not been fully…”
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10
Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels
Published in British journal of pharmacology (01-10-2022)“…Background and Purpose Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clinical needs. As a common…”
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11
Influence of bifenthrin exposure at different gestational stages on the neural development
Published in Ecotoxicology and environmental safety (15-09-2023)“…Perinatal exposure to bifenthrin (BF) alters neurodevelopment. However, the most susceptible time period to BF exposure and the possible mechanisms are not…”
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12
Sonodynamic Therapy Promotes Efferocytosis via CD47 Down-Regulation in Advanced Atherosclerotic Plaque
Published in International Heart Journal (29-01-2022)“…Atherosclerotic cerebrocardiovascular disease is the major cause of acute ischemic diseases in humans. Impaired efferocytosis contributes to the progression of…”
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13
U-shaped association between the triglyceride-glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease
Published in Cardiovascular diabetology (18-05-2023)“…The triglyceride-glucose (TyG) index has been shown to be a new alternative measure for insulin resistance. However, no study has attempted to investigate the…”
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14
Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone
Published in Human molecular genetics (01-07-2012)“…Premutation CGG repeat expansions (55-200 CGG repeats; preCGG) within the fragile X mental retardation 1 (FMR1) gene cause fragile X-associated tremor/ataxia…”
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15
Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons
Published in The Journal of pharmacology and experimental therapeutics (01-01-2011)“…Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their gating kinetics, thereby disrupting neuronal function. Pyrethroids have…”
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16
Rapid inhibition of atherosclerotic plaque progression by sonodynamic therapy
Published in Cardiovascular research (01-01-2019)“…Abstract Aims Currently, efficient regimens to reverse atherosclerotic plaques are not available in the clinic. Herein, we present sonodynamic therapy (SDT) as…”
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17
BmK AEP, an Anti-Epileptic Peptide Distinctly Affects the Gating of Brain Subtypes of Voltage-Gated Sodium Channels
Published in International journal of molecular sciences (08-02-2019)“…BmK AEP, a scorpion peptide purified form the venom of Karsch, has been reported to display anti-epileptic activity. Voltage-gated sodium channels (VGSCs) are…”
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Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors
Published in Environmental health perspectives (01-06-2019)“…The pyrethroid deltamethrin (DM) is broadly used for insect control. Although DM hyperexcites neuronal networks by delaying inactivation of axonal…”
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19
Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels
Published in British journal of pharmacology (01-09-2021)“…Background and Purpose Cocamide monoethanolamide (CMEA) is commonly used as a surfactant‐foam booster in cosmetic formulations. Upon contact with the eye or…”
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20
Signaling defects in iPSC-derived fragile X premutation neurons
Published in Human molecular genetics (01-09-2012)“…Fragile X-associated tremor/ataxia syndrome (FXTAS) is a leading monogenic neurodegenerative disorder affecting premutation carriers of the fragile X (FMR1)…”
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