Search Results - "Cao, Wangsen"

Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases by Zhang, Lijun, Cao, Wangsen

“…Development and progression of many kidney diseases are substantially influenced by aberrant protein acetylation modifications of gene expression crucial for…”
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Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation by Yin, Shasha, Cao, Wangsen

“…Toll-like receptors (TLRs) induce inflammation and tissue repair through multiple signaling pathways. The Nrf2 pathway plays a key role in defending against…”
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Epigenetic modifications of Klotho expression in kidney diseases by Xia, Jinkun, Cao, Wangsen

“…Developments of many renal diseases are substantially influenced by epigenetic modifications of numerous genes, mainly mediated by DNA methylations, histone…”
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Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis by Chen, Fang, Gao, Qi, Wei, Ai, Chen, Xingren, Shi, Yujun, Wang, Hongwei, Cao, Wangsen

“…Development of renal fibrosis is a hallmark of renal aging and chronic kidney disease of all etiologies and characterized by extensive renal cell injuries and…”
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Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis by Cai, Dawei, Yin, Shasha, Yang, Jun, Jiang, Qing, Cao, Wangsen

“…Osteoarthritis (OA) is a common joint disease that can cause gradual disability among the aging population. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)…”
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Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging by Gao, Qi, Chen, Fang, Zhang, Lijun, Wei, Ai, Wang, Yongxiang, Wu, Zhiwei, Cao, Wangsen

“…DNA methylation alterations play mechanistic roles in aging; however, the epigenetic regulators/mediators causally involved in renal aging remain elusive…”
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Carbon Monoxide―Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia by BING WANG, WANGSEN CAO, BISWAL, Shyam, DORE, Sylvain

“…Carbon monoxide (CO) is a gaseous second messenger produced when heme oxygenase enzymes catabolize heme. We have demonstrated that CO can be therapeutic in…”
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Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis by Chen, Xingren, Zhu, Xiaobo, Wei, Ai, Chen, Fang, Gao, Qi, Lu, Ke, Jiang, Qing, Cao, Wangsen

“…Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD) that often leads to fragility fracture, and its development is affected…”
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Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy by Qin, Tian, Du, Ronghui, Huang, Fengjie, Yin, Shasha, Yang, Jun, Qin, Siyuan, Cao, Wangsen

“…Sinomenine is originally derived from medicinal herb and used preferentially in treatment of rheumatoid diseases in Far East regions. SIN has strong…”
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An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models by Niu, Mengyuan, Li, Li, Su, Zhonglan, Wei, Lulu, Pu, Wenyuan, Zhao, Chen, Ding, Yibing, Wazir, Junaid, Cao, Wangsen, Song, Shiyu, Gao, Qian, Wang, Hongwei

“…Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia,…”
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Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly by Ding, Wenwen, Ding, Zhiquan, Wang, Yong, Zhu, Yan, Gao, Qi, Cao, Wangsen, Du, Ronghui

“…Autophagy and NLRP3 inflammasome were associated with the process of colitis. Drugs targeting NLRP3 inflammasome and autophagy to treat colitis are absent, and…”
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Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage by Wang, Bing, Zhu, Xiaolei, Kim, YunTai, Li, Jie, Huang, Siyuan, Saleem, Sofiyan, Li, Rung-chi, Xu, Yun, Dore, Sylvain, Cao, Wangsen

“…Interest in histone deacetylase (HDAC)-based therapeutics as a potential treatment for stroke has grown dramatically. The neuroprotection of HDAC inhibition…”
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Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling by Cao, Wangsen, Bao, Clare, Padalko, Elizaveta, Lowenstein, Charles J

“…The mitogen-activated protein kinase (MAPK) pathway plays a critical role in Toll-like receptor (TLR) signaling. MAPK phosphatase-1 (MKP-1) inhibits the MAPK…”
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Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen‐activated protein kinase phosphatase‐1 by Jeong, Youngtae, Du, Ronghui, Zhu, Xiaolei, Yin, Shasha, Wang, Jian, Cui, Hengmi, Cao, Wangsen, Lowenstein, Charles J.

“…HDAC1, 2, and 3 isoforms regulate innate immune responses by deacetylating MKP‐1, and are potential therapeutic targets in inflammatory diseases. The MAPK…”
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Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS by Wang, Daojuan, Zhu, Zhengquan, Fu, Yu, Zhang, Qiong, Zhang, Yi, Wang, Tingyu, Weng, Yajing, Wen, Yanting, Cao, Wangsen, Tao, Gaojian, Wang, Yong

“…Polycystic ovary syndrome (PCOS) is an endocrine disorder and the main cause of anovulatory infertility, in which persistent activation of androgen receptor…”
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PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice by Wu, He, Wu, Tao, Hua, Wei, Dong, Xianghui, Gao, Yufeng, Zhao, Xiaochun, Chen, Wenwu, Cao, Wangsen, Yang, Qingwu, Qi, Jiping, Zhou, Jin, Wang, Jian

“…Abstract Intracerebral hemorrhage (ICH) is a devastating form of stroke. Misoprostol, a synthetic prostaglandin E1 (PGE1 ) analog and PGE2 receptor agonist,…”
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HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression by Zhang, Lijun, Chen, Fang, Dong, Jian, Wang, Rong, Bi, Guangyu, Xu, Daoliang, Zhang, Yingwei, Deng, Yijun, Lin, Wenjun, Yang, Zhongzhou, Cao, Wangsen

“…Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury…”
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Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation by Qin, SiYuan, Du, RongHui, Yin, ShaSha, Liu, XinFeng, Xu, GeLin, Cao, Wangsen

“…Introduction Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not…”
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GPIHBP1 autoantibody is an independent risk factor for the recurrence of hypertriglyceridemia-induced acute pancreatitis by Zhang, Guofu, Yang, Qi, Mao, Wenjian, Hu, Yuepeng, Pu, Na, Deng, Hongbin, Yu, Xianqiang, Zhang, Jingzhu, Zhou, Jing, Ye, Bo, Li, Gang, Li, Baiqiang, Ke, Lu, Tong, Zhihui, Murakami, Masami, Kimura, Takao, Nakajima, Katsuyuki, Cao, Wangsen, Liu, Yuxiu, Li, Weiqin

“…•HTG-AP patients had a higher rate of GPIHBP1 autoantibody than reported HTG patients.•The GPIHBP1 autoantibody-positive group had a high recurrence rate of…”
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Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis by Ma, Xiaojie, Dong, Xiaowu, Xu, Yao, Ma, Nan, Wei, Mei, Xie, Xiaochun, Lu, Yingying, Cao, Wangsen, Lu, Guotao, Li, Weiqin

“…Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream…”
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