Aging Atlas: a multi-omics database for aging biology

Abstract Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput ‘multi-omics’ datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics and pharmacogenomics)...

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Published in:	Nucleic acids research Vol. 49; no. D1; pp. D825 - D830
Main Authors:	Liu, Guang-Hui, Bao, Yiming, Qu, Jing, Zhang, Weiqi, Zhang, Tao, Kang, Wang, Yang, Fei, Ji, Qianzhao, Jiang, Xiaoyu, Ma, Yingke, Ma, Shuai, Liu, Zunpeng, Chen, Siyu, Wang, Si, Sun, Shuhui, Geng, Lingling, Yan, Kaowen, Yan, Pengze, Fan, Yanling, Song, Moshi, Ren, Jie, Wang, Qiaoran, Yang, Shanshan, Yang, Yuanhan, Xiong, Muzhao, Liang, Chuqiang, Li, Lan-Zhu, Cao, Tianling, Hu, Jianli, Yang, Ping, Ping, Jiale, Hu, Huifang, Zheng, Yandong, Sun, Guoqiang, Li, Jiaming, Liu, Lixiao, Zou, Zhiran, Ding, Yingjie, Li, Mingheng, Liu, Di, Wang, Min, Sun, Xiaoyan, Wang, Cui, Bi, Shijia, Shan, Hezhen, Zhuo, Xiao
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 08-01-2021
Subjects:	Aging - genetics Database Issue Databases, Genetic Epigenomics Genomics Humans Pharmacogenetics Transcriptome - genetics
Online Access:	Get full text
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Summary:	Abstract Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput ‘multi-omics’ datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics and pharmacogenomics), at either populational or single-cell levels, can provide a multi-dimensional, integrated profile of the heterogeneous aging process with unprecedented throughput and detail. These new strategies allow for the exploration of the molecular profile and regulatory status of gene expression during aging, and in turn, facilitate the development of new aging interventions. With a continually growing volume of valuable aging-related data, it is necessary to establish an open and integrated database to support a wide spectrum of aging research. The Aging Atlas database aims to provide a wide range of life science researchers with valuable resources that allow access to a large-scale of gene expression and regulation datasets created by various high-throughput omics technologies. The current implementation includes five modules: transcriptomics (RNA-seq), single-cell transcriptomics (scRNA-seq), epigenomics (ChIP-seq), proteomics (protein–protein interaction), and pharmacogenomics (geroprotective compounds). Aging Atlas provides user-friendly functionalities to explore age-related changes in gene expression, as well as raw data download services. Aging Atlas is freely available at https://bigd.big.ac.cn/aging/index.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Members of Aging Atlas Consortium (arranged by modules) are listed in Appendix section.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/gkaa894