Search Results - "Cao, Meiwan"
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Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes
Published in The Journal of immunology (1950) (01-03-2017)“…In myelodysplastic syndromes (MDS), functional defects of neutrophils result in high mortality because of infections; however, the molecular basis remains…”
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Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells
Published in Biological research (24-03-2020)“…Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of…”
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miR-34a induces neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production
Published in Redox report : communications in free radical research (31-12-2022)“…The number of neutrophils is significantly reduced in myelodysplastic syndrome (MDS), but the molecular basis remains unclear. We recently found that miR-34a…”
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Omeprazole, an inhibitor of proton pump, suppresses De novo lipogenesis in gastric epithelial cells
Published in Biomedicine & pharmacotherapy (01-10-2020)“…•Omeprazole suppressed FASN and ACLY expression, leading to attenuate lipid content.•Neither clarithromycin nor amoxicillin has no effect on FASN and ACLY…”
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The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization
Published in Frontiers in immunology (2023)“…Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder affecting millions worldwide. Due to the complexity of its pathogenesis, the treatment…”
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miR-155-5p PROMOTES CD34+ APOPTOSIS AND INHIBITS BONE MARROW HEMATOPOIESIS IN MYELODYSPLASTIC SYNDROMES BY RAC1/CREB/MIR-15B AXIS
Published in Mediterranean journal of hematology and infectious diseases (29-06-2023)“…Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since…”
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Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients
Published in PloS one (11-08-2016)“…Although increased TNF-α has been considered to cause ineffective hematopoiesis in myelodysplastic syndromes (MDS), the mechanisms of TNF-α elevation are not…”
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Shikonin contributes to intestinal epithelial cell differentiation through PKM2/NRF2-mediated Polyol pathway
Published in Pharmacological research. Modern Chinese medicine (01-12-2021)“…Alteration of polyol pathway is a critical event in serials of disease, including inflammatory bowel disease (IBD). Shikonin, an inhibitor of PKM2, has been…”
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Involvement of aquaporins in a mouse model of rotavirus diarrhea
Published in Virologica Sinica (01-08-2014)“…Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water…”
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Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function
Published in Cell proliferation (01-11-2019)“…Objective Inflammatory bowel disease (IBD) is a disorder intestinal inflammation and impaired barrier function, associated with increased epithelial expression…”
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Impaired Neutrophil Migration Resulting from Mir-34a and Mir-155 Overexpressed in Neutrophils from Myelodysplastic Syndrome Patients
Published in Blood (03-12-2015)“…In myelodysplastic syndromes (MDS), functional defects of neutrophils result in high mortality due to infections. However, the molecular basis of neutrophil…”
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Excessive TNF-α Production Results from Reduction of c-Fos Via Aberrant Expression of Mir-34a in Neutrophils from Myelodysplastic Syndrome Patients
Published in Blood (03-12-2015)“…The molecular basis of ineffective hematopoiesis in myelodysplastic syndromes (MDS) has yet to be defined. Elevation of tumor necrosis factor (TNF)-α in bone…”
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The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes
Published in Mediterranean journal of hematology and infectious diseases (2023)“…Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since…”
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