Search Results - "Cao, Kaixiang"
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Experimental investigation of field distributions for chirped fiber Bragg grating
Published in Applied physics letters (03-07-2023)“…Chirped fiber Bragg gratings (CFBGs) are used in applications ranging from fiber optic communication, optical fiber sensing, to optical information processing,…”
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Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
Published in Nature communications (22-08-2023)“…The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation
Published in Nature genetics (01-06-2020)“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Published in Nature genetics (01-11-2017)“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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PAF1 regulation of promoter-proximal pause release via enhancer activation
Published in Science (American Association for the Advancement of Science) (22-09-2017)“…Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously,we showed that Pol II–associated…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation
Published in Genes & development (01-09-2017)“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations
Published in The Journal of clinical investigation (03-07-2023)“…Epigenetic status-altering mutations in chromatin-modifying enzymes are a feature of human diseases, including many cancers. However, the functional outcomes…”
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SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression
Published in Genes & development (15-04-2017)“…The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Published in Genes & development (01-10-2017)“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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High-resolution mapping of h1 linker histone variants in embryonic stem cells
Published in PLoS genetics (01-04-2013)“…H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d…”
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Histone h1 depletion impairs embryonic stem cell differentiation
Published in PLoS genetics (01-05-2012)“…Pluripotent embryonic stem cells (ESCs) are known to possess a relatively open chromatin structure; yet, despite efforts to characterize the chromatin…”
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Reduction of Hox gene expression by histone H1 depletion
Published in PloS one (11-06-2012)“…The evolutionarily conserved homeotic (Hox) genes are organized in clusters and expressed collinearly to specify body patterning during embryonic development…”
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13
Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family
Published in Science advances (01-06-2020)“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells
Published in Science advances (01-01-2018)“…Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the…”
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Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors
Published in Stem cell research (01-07-2013)“…Understanding how to specify rapid differentiation of human neural progenitor towards enriched non-transformed human astrocyte progenitors will provide a…”
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Inhibit Globally, Act Locally: CDK7 Inhibitors in Cancer Therapy
Published in Cancer cell (11-08-2014)“…Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and…”
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17
Optical All-Pass Filter Based on Dual-Injection MRR With Arbitrary Coupling Coefficients
Published in Journal of lightwave technology (01-11-2024)“…An optical all-pass filter (APF) has unified amplitude response and varied phase response, enabling phase manipulation without causing amplitude degradation…”
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Reconfigurable Bandpass Microwave Photonic Filter Based on Cascaded Second-Order CROWs
Published in Journal of lightwave technology (15-08-2024)“…The microwave photonic filter (MPF) integrates photonic and microwave technology to carry out a variety of microwave band filtering applications. The…”
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Integrated waveguide coupled ultralow-loss multimode waveguides based on silicon nitride resonators
Published in Optics express (15-01-2024)“…On-chip micro-ring resonators (MRRs) with low loss and large free spectral ranges (FSRs) are important for photonic devices. So far, ultra-low-loss…”
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Ultrasensitive and reversible room-temperature resistive humidity sensor based on layered two-dimensional titanium carbide
Published in Ceramics international (01-03-2021)“…The nanostructured two-dimensional (2D) materials for humidity sensing applications have become increasingly attractive. However, 2D materials have negative…”
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