Search Results - "Cao, Carolyn"

Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells by CAO, Carolyn, SUBHAWONG, Ty, ALBERT, Jeffrey M, KWANG WOON KIM, LING GENG, SEKHAR, Konjeti R, YOUNG JIN GI, BO LU

“…The phosphatidylinositol 3-kinase/Akt pathway plays a critical role in oncogenesis, and dysregulation of this pathway through loss of PTEN suppression is a…”
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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR by Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

“…BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, <2 nmol/L). It is currently…”
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Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models by Albert, Jeffrey M, Cao, Carolyn, Kim, Kwang Woon, Willey, Christopher D, Geng, Ling, Xiao, Dakai, Wang, Hong, Sandler, Alan, Johnson, David H, Colevas, Alexander D, Low, Jennifer, Rothenberg, Mace L, Lu, Bo

“…Purpose: Poly(ADP-ribose) polymerase-1 (PARP-1) is the founding member of a family of enzymes that catalyze the addition of ADP-ribose units to proteins that…”
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Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer by Albert, Jeffrey M, Kim, Kwang Woon, Cao, Carolyn, Lu, Bo

“…The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is known to be activated by radiation. The mammalian target of rapamycin (mTOR) is downstream of Akt, and…”
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Autophagy for Cancer Therapy through Inhibition of Pro-apoptotic Proteins and Mammalian Target of Rapamycin Signaling by Kim, Kwang Woon, Mutter, Robert W., Cao, Carolyn, Albert, Jeffrey M., Freeman, Michael, Hallahan, Dennis E., Lu, Bo

“…Autophagy is an alternative cell death pathway that is induced by mammalian target of rapamycin (mTOR) inhibitors and up-regulated when apoptosis is defective…”
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DGKζ exerts greater control than DGKα over CD8 + T cell activity and tumor inhibition by Gu, Junchen, Wang, Cindy, Cao, Carolyn, Huang, Jinwen, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin M, Evans, Douglas B, Benci, Joseph, Wichroski, Michael, Wee, Susan, Riese, Matthew J

“…Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T…”
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Enhanced radiation damage of tumor vasculature by mTOR inhibitors by SHINOHARA, Eric T, CAO, Carolyn, NIERMANN, Ken, YI MU, FENGHUA ZENG, HALLAHAN, Dennis E, BO LU

“…It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to…”
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XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer by CAO, Carolyn, YI MU, HALLAHAN, Dennis E, LU, Bo

“…Survivin and XIAP are members of inhibitors of apoptosis (IAPs) family. They are upregulated in various malignancies. Inactivation of these molecules has…”
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Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer by CAO, Carolyn, ALBERT, Jeffrey M, LING GENG, IVY, Percy S, SANDLER, Alan, JOHNSON, David H, BO LU

“…The vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are being explored as targets for antiangiogenic cancer therapy. Radiotherapy also…”
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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor by Emanuel, Stuart L., Engle, Linda J., Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron P., Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent A., Carvajal, Irvith M., Fabrizio, David, Wright, Martin C., Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P., Doyle, Michael L., Wong, Tai W., Camphausen, Raymond T., Cload, Sharon T., Marsh, H. Nicholas, Gottardis, Marco M., Furfine, Eric S.

“…Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and…”
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Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2 by Cao, Carolyn, Shinohara, Eric T, Subhawong, Ty K, Geng, Ling, Kim, Kwang Woon, Albert, Jeffrey M, Hallahan, Dennis E, Lu, Bo

“…p53 plays a critical role in cell cycle arrest and induction of apoptosis. Certain malignancies carry wild-type p53, which is frequently down-regulated by…”
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Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation by Kim, Kwang Woon, Mutter, Robert W, Cao, Carolyn, Albert, Jeffrey M, Shinohara, Eric T, Sekhar, Konjeti R, Lu, Bo

“…Signal transducer and activator of transcription 3 (Stat3) and Survivin are constitutively up-regulated in various human tumor cells. We previously found…”
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Inhibition of Survivin and Aurora B Kinase Sensitizes Mesothelioma Cells by Enhancing Mitotic Arrests by Kim, Kwang Woon, Ph.D, Mutter, Robert W., B.A, Willey, Christopher D., M.D., Ph.D, Subhawong, Ty K., M.D, Shinohara, Eric T., M.D, Albert, Jeffrey M., B.S, Ling, Geng, Ph.D, Cao, Carolyn, B.S, Gi, Young Jin, M.S, Lu, Bo, M.D., Ph.D

“…Purpose: Survivin, a member of the inhibitor of apoptosis gene family, has also been shown to regulate mitosis. It binds Aurora B kinase and the inner…”
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SGLT2I-ASSOCIATED EUGLYCEMIC DIABETIC KETOACIDOSIS IN THE SETTING OF ACUTE CORONARY SYNDROME by Cao, Carolyn, Stock, James, Emani, Sitaramesh

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An Additional Electrostatic Interaction between Adrenodoxin and P450c27 (CYP27A1) Results in Tighter Binding Than between Adrenodoxin and P450scc (CYP11A1) by Pikuleva, Irina A., Cao, Carolyn, Waterman, Michael R.

“…Mitochondrial cytochrome P450c27 (product of the CYP27A1 gene) is found to have significantly higher affinity for the common redox partner adrenodoxin than…”
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Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer by Cao, Carolyn, Shinohara, Eric T, Niermann, Kenneth J, Donnelly, Edwin F, Chen, Xinping, Hallahan, Dennis E, Lu, Bo

“…Murine double minute 2 (MDM2) inhibits p53-mediated functions, which are essential for therapies using DNA-damaging agents. The purpose of this study was to…”
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Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ by Wee, Susan, Gu, Junchen, Wang, Cindy, Cao, Carolyn, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin, Tsai, Susan, Evans, Douglas, Riese, Matthew

“…Abstract Diacylglycerol kinases (DGKs) are a family of enzymes that metabolize the lipid diacylglycerol (DAG) to form phosphatidic acid. In T cells, two…”
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PO-03-140 CARDIAC MAGNETIC RESONANCE IMAGING VERSUS CARDIAC COMPUTED TOMOGRAPHY ANGIOGRAPHY FOR LEFT ATRIAL APPENDAGE SIZING AND THROMBUS ASSESSMENT PRIOR TO DEVICE CLOSURE by Bhuta, Sapan, Cao, Carolyn, Horbal, Piotr J., Sleiman, Jose, Sirinvaravong, Natee, Lee, John J., Wallace, Grant M., Augostini, Ralph S., Kalbfleisch, Steven J., Savona, Salvatore, Okabe, Toshimasa, Hummel, John D., Daoud, Emile G., Afzal, M. Rizwan, Houmsse, Mahmoud

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HIGH RESOLUTION CARDIAC MAGNETIC RESONANCE IMAGING WITH TRUPLAN SOFTWARE BASED SIZING FOR LEFT ATRIAL APPENDAGE CLOSURE WITH THE WATCHMAN FLX DEVICE by Bhuta, Sapan, Cao, Carolyn, Pieper, Justin, Stoycos, Stephen, Varghese, Juliet, Tong, Matthew S., Harfi, Thura T., Han, Yuchi, Simonetti, Orlando P., Sirinvaravong, Natee, Sleiman, Jose, Lee, John, Wallace, Grant, Daoud, Emile G., Augostini, Ralph S., Weiss, Raul, Kalbfleisch, Steven Jack, Savona, Salvatore, Hummel, John D., Okabe, Toshimasa, Afzal, Muhammad Rizwan, Houmsse, Mahmoud

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DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity by Wichroski, Michael, Benci, Joseph, Liu, Si-Qi, Chupak, Louis, Fang, Jie, Cao, Carolyn, Wang, Cindy, Onorato, Joelle, Qiu, Hongchen, Shan, Yongli, Banas, Dana, Powles, Ryan, Locke, Gregory, Witt, Abigail, Stromko, Caitlyn, Qi, Huilin, Zheng, Xiaofan, Martin, Scott, Ding, Min, Gentles, Robert, Meanwell, Nicholas, Velaparthi, Upender, Olson, Richard, Wee, Susan, Tenney, Daniel, Parker, Christopher G, Cravatt, Benjamin F, Lawrence, Michael, Borzilleri, Robert, Lees, Emma

“…Programmed cell death protein 1 (PD-1) immune checkpoint blockade therapy has revolutionized cancer treatment. Although PD-1 blockade is effective in a subset…”
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