Search Results - "Canzi, Alice"
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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
Published in Immunity (Cambridge, Mass.) (15-05-2018)“…The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune receptor associated with a lethal form of early, progressive…”
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Journal Article -
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Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1‐integrin
Published in The EMBO journal (03-01-2019)“…Control of synapse number and function in the developing central nervous system is critical to the formation of neural circuits. Astrocytes play a key role in…”
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Journal Article -
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The Communication Between the Immune and Nervous Systems: The Role of IL-1β in Synaptopathies
Published in Frontiers in molecular neuroscience (05-04-2018)“…In the last 15 years, groundbreaking genetic progress has underlined a convergence onto coherent synaptic pathways for most psychiatric and neurodevelopmental…”
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Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects
Published in eLife (28-03-2017)“…Inflammation modifies risk and/or severity of a variety of brain diseases through still elusive molecular mechanisms. Here we show that hyperactivation of the…”
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Journal Article