Search Results - "Canu, Valeria"

CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals by Palcau, Alina Catalina, Canu, Valeria, Donzelli, Sara, Strano, Sabrina, Pulito, Claudio, Blandino, Giovanni

“…The role of circular RNAs in oncogenesis has begun to be widely studied in recent years, due to the significant impact that these molecules have in disease…”
Get full text

Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation by Canu, Valeria, Donzelli, Sara, Sacconi, Andrea, Lo Sardo, Federica, Pulito, Claudio, Bossel, Noa, Di Benedetto, Anna, Muti, Paola, Botti, Claudio, Domany, Eytan, Bicciato, Silvio, Strano, Sabrina, Yarden, Yosef, Blandino, Giovanni

“…Sperm-associated antigen 5 (SPAG5) is an important driver of the cell mitotic spindle required for chromosome segregation and progression into anaphase. SPAG5…”
Get full text

Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer by Canu, Valeria, Vaccarella, Sebastiano, Sacconi, Andrea, Pulito, Claudio, Goeman, Frauke, Pallocca, Matteo, Rutigliano, Daniela, Lev, Sima, Strano, Sabrina, Blandino, Giovanni

“…Triple negative breast cancer (TNBC) is an aggressive disease which currently has no effective therapeutic targets and prominent biomarkers. The Sperm…”
Get full text

HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis by Di Agostino, Silvia, Canu, Valeria, Donzelli, Sara, Pulito, Claudio, Sacconi, Andrea, Ganci, Federica, Valenti, Fabio, Goeman, Frauke, Scalera, Stefano, Rollo, Francesca, Bagnato, Anna, Diodoro, Maria Grazia, Vizza, Enrico, Carosi, Mariantonia, Rufini, Beatrice, Federici, Orietta, Giofrè, Manuel, Carboni, Fabio, Muti, Paola, Ciliberto, Gennaro, Strano, Sabrina, Valle, Mario, Blandino, Giovanni

“…Hyperthermic intraperitoneal administration of chemotherapy (HIPEC) increases local drug concentrations and reduces systemic side effects associated with…”
Get full text

Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids by Cioce, Mario, Fumagalli, Maria Rita, Donzelli, Sara, Goeman, Frauke, Canu, Valeria, Rutigliano, Daniela, Orlandi, Giulia, Sacconi, Andrea, Pulito, Claudio, Palcau, Alina Catalina, Fanciulli, Maurizio, Morrone, Aldo, Diodoro, Maria Grazia, Caricato, Marco, Crescenzi, Anna, Verri, Martina, Fazio, Vito Michele, Zapperi, Stefano, Levrero, Massimo, Strano, Sabrina, Grazi, Gian Luca, La Porta, Caterina, Blandino, Giovanni

“…Approximately 20-50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and…”
Get full text

miR‐10b, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours by Biagioni, Francesca, Bossel Ben‐Moshe, Noa, Fontemaggi, Giulia, Canu, Valeria, Mori, Federica, Antoniani, Barbara, Di Benedetto, Anna, Santoro, Raffaela, Germoni, Sabrina, De Angelis, Fernanda, Cambria, Anna, Avraham, Roi, Grasso, Giuseppe, Strano, Sabrina, Muti, Paola, Mottolese, Marcella, Yarden, Yosef, Domany, Eytan, Blandino, Giovanni

“…Deregulated proliferation is a hallmark of cancer cells. Here, we show that microRNA‐10b* is a master regulator of breast cancer cell proliferation and is…”
Get full text

MiR-204 down-regulation elicited perturbation of a gene target signature common to human cholangiocarcinoma and gastric cancer by Canu, Valeria, Sacconi, Andrea, Lorenzon, Laura, Biagioni, Francesca, Lo Sardo, Federica, Diodoro, Maria Grazia, Muti, Paola, Garofalo, Alfredo, Strano, Sabrina, D'Errico, Antonietta, Grazi, Gian Luca, Cioce, Mario, Blandino, Giovanni

“…There is high need of novel diagnostic and prognostic tools for tumors of the digestive system, such as gastric cancer and cholangiocarcinoma. We recently…”
Get full text

miR-181c associates with tumor relapse of high grade osteosarcoma by Mori, Federica, Sacconi, Andrea, Canu, Valeria, Ganci, Federica, Novello, Mariangela, Anelli, Vincenzo, Covello, Renato, Ferraresi, Virginia, Muti, Paola, Biagini, Roberto, Blandino, Giovanni, Strano, Sabrina

“…High-grade osteosarcoma (OS) is characterized by low incidence, high aggressiveness and moderate 5-years survival rate after aggressive poly-chemotherapy and…”
Get full text

YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers by Lo Sardo, Federica, Canu, Valeria, Maugeri-Saccà, Marcello, Strano, Sabrina, Blandino, Giovanni

“…The transcriptional regulators YAP and TAZ are involved in numerous physiological processes including organ development, growth, immunity and tissue…”
Get full text

Cancer Gastric Chemoprevention: Isolation of Gastric Tumor-Initiating Cells by Mori, Federica, Canu, Valeria, Lorenzon, Laura, Garofalo, Alfredo, Blandino, Giovanni, Strano, Sabrina

“…Gastric cancer is an important healthcare problem and represents the second leading cause of death for malignant disease worldwide. In the Western world, the…”
Get more information

Down‐regulated miRs specifically correlate with non‐cardial gastric cancers and Lauren's classification system by Lorenzon, Laura, Cippitelli, Claudia, Avantifiori, Riccardo, Uccini, Stefania, French, Deborah, Torrisi, Maria Rosaria, Ranieri, Danilo, Mercantini, Paolo, Canu, Valeria, Blandino, Giovanni, Cavallini, Marco

“…Background and Objectives Gastric cancers are usually characterized using Lauren's classification into intestinal and diffuse types. We previously documented…”
Get full text