Search Results - "Cantor, Sharon B"

Replication fork stability confers chemoresistance in BRCA-deficient cells by Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

“…Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are…”
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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling by Lee, Wei Ting C., Yin, Yandong, Morten, Michael J., Tonzi, Peter, Gwo, Pam Pam, Odermatt, Diana C., Modesti, Mauro, Cantor, Sharon B., Gari, Kerstin, Huang, Tony T., Rothenberg, Eli

“…Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading…”
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Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4 by Guillemette, Shawna, Serra, Ryan W, Peng, Min, Hayes, Janelle A, Konstantinopoulos, Panagiotis A, Green, Michael R, Cantor, Sharon B

“…Hereditary cancers derive from gene defects that often compromise DNA repair. Thus, BRCA-associated cancers are sensitive to DNA-damaging agents such as…”
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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells by Cong, Ke, MacGilvary, Nathan, Lee, Silviana, MacLeod, Shannon G., Calvo, Jennifer, Peng, Min, Nedergaard Kousholt, Arne, Day, Tovah A., Cantor, Sharon B.

“…The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA…”
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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress by Peng, Min, Cong, Ke, Panzarino, Nicholas J., Nayak, Sumeet, Calvo, Jennifer, Deng, Bin, Zhu, Lihua Julie, Morocz, Monika, Hegedus, Lili, Haracska, Lajos, Cantor, Sharon B.

“…The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease…”
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Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses by Peng, Min, Xie, Jenny, Ucher, Anna, Stavnezer, Janet, Cantor, Sharon B

“…Several proteins in the BRCA‐Fanconi anemia (FA) pathway, such as FANCJ, BRCA1, and FANCD2, interact with mismatch repair (MMR) pathway factors, but the…”
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Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1 by Cantor, Sharon B, Guillemette, Shawna

“…It is clear that FANCJ, also known as BACH1 or BRIP1, is an essential tumor suppressor gene based on the identification of clinically relevant mutations not…”
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Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability by Nayak, Sumeet, Calvo, Jennifer A, Cong, Ke, Peng, Min, Berthiaume, Emily, Jackson, Jessica, Zaino, Angela M, Vindigni, Alessandro, Hadden, M Kyle, Cantor, Sharon B

“…The replication stress response, which serves as an anticancer barrier, is activated not only by DNA damage and replication obstacles but also oncogenes, thus…”
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RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination by Barber, Louise J., Youds, Jillian L., Ward, Jordan D., McIlwraith, Michael J., O'Neil, Nigel J., Petalcorin, Mark I.R., Martin, Julie S., Collis, Spencer J., Cantor, Sharon B., Auclair, Melissa, Tissenbaum, Heidi, West, Stephen C., Rose, Ann M., Boulton, Simon J.

“…Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity. Inappropriate HR causes gross…”
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Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia by Brosh, Jr, Robert M, Cantor, Sharon B

“…The FANCJ DNA helicase is mutated in hereditary breast and ovarian cancer as well as the progressive bone marrow failure disorder Fanconi anemia (FA). FANCJ is…”
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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes by Greenberg, Roger A, Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B, Nakatani, Yoshihiro, Livingston, David M

“…The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire…”
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Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer" by Cantor, Sharon B

“…The toxic lesion emanating from chemotherapy that targets the DNA was initially debated, but eventually the DNA double strand break (DSB) ultimately prevailed…”
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Exploiting replication gaps for cancer therapy by Cong, Ke, Cantor, Sharon B

“…Defects in DNA double-strand break repair are thought to render BRCA1 or BRCA2 (BRCA) mutant tumors selectively sensitive to PARP inhibitors (PARPis)…”
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Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome by Suhasini, Avvaru N, Rawtani, Nina A, Wu, Yuliang, Sommers, Joshua A, Sharma, Sudha, Mosedale, Georgina, North, Phillip S, Cantor, Sharon B, Hickson, Ian D, Brosh Jr, Robert M

“…Bloom's syndrome (BS) and Fanconi anemia (FA) are autosomal recessive disorders characterized by cancer and chromosomal instability. BS and FA group J arise…”
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FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation by Guillemette, Shawna, Branagan, Amy, Peng, Min, Dhruva, Aashana, Schärer, Orlando D, Cantor, Sharon B

“…Nucleotide excision repair (NER) is critical for the repair of DNA lesions induced by UV radiation, but its contribution in replicating cells is less clear…”
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FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange by Sommers, Joshua A., Rawtani, Nina, Gupta, Rigu, Bugreev, Dmitry V., Mazin, Alexander V., Cantor, Sharon B., Brosh, Robert M.

“…Mutations in the FANCJ helicase predispose individuals to breast cancer and are genetically linked to the Fanconi anemia (FA) complementation group J. FA is a…”
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Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response by Suhasini, Avvaru N., Sommers, Joshua A., Muniandy, Parameswary A., Coulombe, Yan, Cantor, Sharon B., Masson, Jean-Yves, Seidman, Michael M., Brosh, Robert M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response by Xie, Jenny, Peng, Min, Guillemette, Shawna, Quan, Steven, Maniatis, Stephanie, Wu, Yuliang, Venkatesh, Aditya, Shaffer, Scott A, Brosh, Jr, Robert M, Cantor, Sharon B

“…BRCA1 promotes DNA repair through interactions with multiple proteins, including CtIP and FANCJ (also known as BRIP1/BACH1). While CtIP facilitates DNA end…”
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Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer by MacGilvary, Nathan, Cantor, Sharon B.

“…The mechanisms by which poly(ADP-ribose) polymerase 1 (PARP1) inhibitors (PARPi)s inflict replication stress and/or DNA damage are potentially numerous. PARPi…”
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Analysis of the DNA Substrate Specificity of the Human BACH1 Helicase Associated with Breast Cancer by Gupta, Rigu, Sharma, Sudha, Sommers, Joshua A, Jin, Zhe, Cantor, Sharon B, Brosh, Jr, Robert M

“…We have investigated the DNA substrate specificity of BACH1 ( B RCA1- a ssociated C -terminal h elicase). The importance of various DNA structural elements for…”
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