Search Results - "Cantoni, O"

ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite by Cerioni, L., Cantoni, O.

“…Previous studies from our laboratory indicate that cytosolic phospholipase A2 (cPLA2)‐released arachidonic acid promotes monocyte/macrophage survival in the…”
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Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 by Tommasini, I, Sestili, P, Guidarelli, A, Cantoni, O

“…We have studied the relationships existing between delayed formation of H2O2 and activation of cytosolic phospholipase A2 (cPLA2), events respectively…”
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Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death by Tommasini, I, Sestili, P, Guidarelli, A, Cantoni, O

“…Peroxynitrite stimulates in U937 cells release of arachidonic acid (AA) sensitive to various phospholipase A(2) (PLA(2)) inhibitors, including arachidonyl…”
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Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis by Barsacchi, R, Perrotta, C, Sestili, P, Cantoni, O, Moncada, S, Clementi, E

“…Activation of acid and neutral sphingomyelinases, and the ensuing generation of ceramide, contributes to the biological effects of tumour necrosis factor-alpha…”
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Nitric oxide-mediated redox reactions in pathology, biochemistry and medicine by Brüne, B, Cantoni, O

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Peroxynitrite promotes mitochondrial permeability transition-dependent rapid U937 cell necrosis: survivors proliferate with kinetics superimposable on those of untreated cells by Sestili, P, Tommasini, I, Cantoni, O

“…A short term exposure to peroxynitrite promotes a time- and concentration-dependent lethal response in U937 cells. The mode of cell death was necrosis and…”
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Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells by Guidarelli, A, De Sanctis, R, Cellini, B, Fiorani, M, Dachà, M, Cantoni, O

“…A well-established protocol to increase the intracellular content of ascorbic acid was used to investigate the effects of the vitamin on DNA single-strand…”
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Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts by Sestili, P, Brandi, G, Brambilla, L, Cattabeni, F, Cantoni, O

“…Pharmacologically attainable concentrations of ascorbic acid are highly toxic for U937 cells (a human promyelocytic cell line), and this response appears to be…”
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Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine by Guidarelli, A, Sestili, P, Cossarizza, A, Franceschi, C, Cattabeni, F, Cantoni, O

“…L-Histidine markedly increases inorganic and organic hydroperoxide-induced cytotoxicity and DNA single-strand breaks (SSBs) in Chinese hamster ovary cells…”
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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS by Nisoli, Enzo, Tonello, Cristina, Cardile, Annalisa, Cozzi, Valeria, Bracale, Renata, Tedesco, Laura, Falcone, Sestina, Valerio, Alessandra, Cantoni, Orazio, Clementi, Emilio, Moncada, Salvador, Carruba, Michele O

“…Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced…”
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Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling by Guidarelli, Andrea, Fiorani, Mara, Cerioni, Liana, Cantoni, Orazio

“…A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine…”
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Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells by Sugiyama, M, Patierno, S R, Cantoni, O, Costa, M

“…Alkaline elution studies demonstrated CaCrO4-induced DNA single strand breaks and DNA-protein crosslinks. DNA single strand breaks increased following…”
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Mitochondrial Biogenesis by NO Yields Functionally Active Mitochondria in Mammals by Nisoli, Enzo, Falcone, Sestina, Tonello, Cristina, Cozzi, Valeria, Palomba, Letizia, Fiorani, Mara, Pisconti, Addolorata, Brunelli, Silvia, Cardile, Annalisa, Francolini, Maura, Cantoni, Orazio, Carruba, Michele O., Moncada, Salvador, Clementi, Emilio, Ignarro, Louis J.

“…We recently found that long-term exposure to nitric oxide (NO) triggers mitochondrial biogenesis in mammalian cells and tissues by activation of guanylate…”
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Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells by Blandino, Giulia, Fiorani, Mara, Canonico, Barbara, De Matteis, Rita, Guidarelli, Andrea, Montanari, Mariele, Buffi, Gloria, Coppo, Lucia, Arnér, Elias S.J., Cantoni, Orazio

“…Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders…”
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Molecular mechanisms mediating resistance of monocytes/macrophages to peroxynitrite by Cantoni, Orazio

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Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells by Cantoni, O, Sestili, P, Guidarelli, A, Giacomoni, P U, Cattabeni, F

“…L-Histidine markedly increased the growth- and DNA synthesis-inhibitory effects elicited by hydrogen peroxide in cultured Chinese hamster ovary cells. DNA…”
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Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A

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A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA by Guidarelli, Andrea, Fiorani, Mara, Azzolini, Catia, Cantoni, Orazio

“…High concentrations of peroxynitrite elicit delayed formation of DNA-damaging species through a mechanism dependent on mitochondrial Ca(2+) accumulation and…”
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L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing by Cantoni, O, Guidarelli, A, Sestili, P, Giacomoni, P U, Cattabeni, F

“…Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA…”
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Correlations of DNA strand breaks and their repair with cell survival following acute exposure to mercury(II) and X-rays by Cantoni, O, Costa, M

“…Alkaline elution analysis demonstrates that both HgCl2 and X-rays result in a rapid induction of DNA single-strand breaks at acutely cytotoxic doses (HgCl2,…”
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