Search Results - "Cantone, Irene"
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Biological impact of lead from halide perovskites reveals the risk of introducing a safe threshold
Published in Nature communications (21-01-2020)“…Regulations currently in force enable to claim that the lead content in perovskite solar cells is low enough to be safe, or no more dangerous, than other…”
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2
X-chromosome reactivation: a concise review
Published in Biochemical Society transactions (17-12-2021)“…Mammalian females (XX) silence transcription on one of the two X chromosomes to compensate the expression dosage with males (XY). This process - named…”
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Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-11-2017)“…X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably…”
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4
A Yeast Synthetic Network for In Vivo Assessment of Reverse-Engineering and Modeling Approaches
Published in Cell (03-04-2009)“…Systems biology approaches are extensively used to model and reverse engineer gene regulatory networks from experimental data. Conversely, synthetic biology…”
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5
DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion
Published in Cell (14-02-2013)“…Embryonic stem cells (ESCs) can instruct the conversion of differentiated cells toward pluripotency following cell-to-cell fusion by a mechanism that is rapid…”
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6
FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo
Published in International journal of molecular sciences (17-07-2021)“…Forkhead box E1 (FOXE1) is a lineage-restricted transcription factor involved in thyroid cancer susceptibility. Cancer-associated polymorphisms map in…”
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7
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming
Published in Nature communications (10-08-2016)“…Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model…”
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8
Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development
Published in Cell reports (Cambridge) (28-07-2015)“…Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition. Unlike other PRC2-deficient embryonic stem cells…”
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9
Efficient parameter search for qualitative models of regulatory networks using symbolic model checking
Published in Bioinformatics (15-09-2010)“…Motivation: Investigating the relation between the structure and behavior of complex biological networks often involves posing the question if the hypothesized…”
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10
Retinoic Acid Induces Embryonic Stem Cells (ESCs) Transition to 2 Cell-Like State Through a Coordinated Expression of Dux and Duxbl1
Published in Frontiers in cell and developmental biology (17-01-2020)“…Embryonic stem cells (ESCs) are derived from inner cell mass (ICM) of the blastocyst. In serum/LIF culture condition, they show variable expression of…”
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11
Replication Timing of Gene Loci in Different Cell Cycle Phases
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…Replication of distinct genomic loci occurs at different times during cell cycle. The replication timing correlates with chromatin status, three-dimensional…”
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12
How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch
Published in PloS one (07-12-2009)“…Systems and Synthetic Biology use computational models of biological pathways in order to study in silico the behaviour of biological pathways. Mathematical…”
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13
Using heterokaryons to understand pluripotency and reprogramming
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (12-08-2011)“…Reprogramming differentiated cells towards pluripotency can be achieved by different experimental strategies including the forced expression of specific…”
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14
Epigenetic programming and reprogramming during development
Published in Nature structural & molecular biology (01-03-2013)“…Global erasure and re-establishment of chromatin-based and DNA-based epigenetic marks occurs naturally in the mammalian life cycle, but it can also be…”
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15
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity
Published in Trends in genetics (01-09-2020)“…High-throughput sequencing and genome-wide association studies have revealed a sex bias in human diseases. The underlying molecular mechanisms remain, however,…”
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16
Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-11-2017)“…X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably…”
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17
Environmental lead exposure from halide perovskites in solar cells
Published in Trends in ecology & evolution (Amsterdam) (01-04-2022)“…Lead (Pb) is one of the most toxic elements in existence and has been used by humans for thousands of years. With only a few exceptions, each widespread…”
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18
Biotoxicity of Halide Perovskites in Mice
Published in Advanced materials (Weinheim) (01-01-2024)“…Halide perovskites are crystalline semiconductors with exceptional optoelectronic properties, rapidly developing toward large‐scale applications. Lead (II)…”
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19
Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation
Published in Genome Biology (25-01-2017)“…Inactivation of one X chromosome is established early in female mammalian development and can be reversed in vivo and in vitro when pluripotency factors are…”
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20
Unraveling Epigenetic Landscapes: The Enigma of Enhancers
Published in Cell stem cell (04-02-2011)“…In recent publications in Nature and PNAS, Rada-Iglesias et al. (2010) and Creyghton et al. (2010) have uncovered unique chromatin signatures of developmental…”
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