Search Results - "Canto, Rômulo F.S."

Selenium-Derivative Compounds: A Review of New Perspectives in the Treatment of Alzheimer's Disease by Barbosa, Flavio A R, Canto, Rômulo F S, Teixeira, Kerolain F, de Souza, Anacleto S, de Oliveira, Aldo S, Braga, Antonio L

“…Alzheimer's disease (AD) is one of the most prevalent types of dementia, affecting millions of older people worldwide. AD is stimulating efforts to develop…”
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Synthesis and biological evaluation of new nitrogen-containing diselenides by Nascimento, Vanessa, Ferreira, Natasha L., Canto, Rômulo F.S., Schott, Karen L., Waczuk, Emily P., Sancineto, Luca, Santi, Claudio, Rocha, João B.T., Braga, Antonio L.

“…The antioxidant properties of organoselenium compounds have been extensively investigated with the aim of developing new drugs, since oxidative stress is…”
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Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease by Barbosa, Flavio A R, Canto, Rômulo F S, Saba, Sumbal, Rafique, Jamal, Braga, Antonio L

“…This paper describes the synthesis and evaluation of new dihydropyrimidinone (DHPM)-derived selenoesters as potential multi-targeted agents for the treatment…”
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Novel pyrimidinic selenourea induces DNA damage, cell cycle arrest, and apoptosis in human breast carcinoma by Barbosa, Flavio A.R., Siminski, Tâmila, Canto, Rômulo F.S., Almeida, Gabriela M., Mota, Nádia S.R.S., Ourique, Fabiana, Pedrosa, Rozangela Curi, Braga, Antonio Luiz

“…Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant…”
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Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics by Botteselle, Giancarlo V., Elias, Welman C., Bettanin, Luana, Canto, Rômulo F. S., Salin, Drielly N. O., Barbosa, Flavio A. R., Saba, Sumbal, Gallardo, Hugo, Ciancaleoni, Gianluca, Domingos, Josiel B., Rafique, Jamal, Braga, Antonio L.

“…Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides…”
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Synthesis of dihydropyrimidin-2-one/thione library and cytotoxic activity against the human U138-MG and Rat C6 glioma cell lines by Canto, Rômulo F. S, Bernardi, Andressa, Battastini, Ana Maria O, Russowsky, Dennis, Eifler-Lima, Vera Lucia

“…Two series of 4-aryl-3,4-dihydropyrimidin-2(1H)-(thio)ones including monastrol (1a), have been synthesized by an environment-friendly methodology based on the…”
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A Novel Diselenide-Probucol-Analogue Protects Against Methylmercury-Induced Toxicity in HT22 Cells by Upregulating Peroxide Detoxification Systems: a Comparison with Diphenyl Diselenide by Quispe, Ruth L., Jaramillo, Michael L., Wolin, Ingrid A. V., Canto, Rômulo F. S., Barbosa, Flavio A. R., Braga, Antônio L., Rocha, João B. T., Aschner, Michael, Leal, Rodrigo B., de Bem, Andreza F., Farina, Marcelo

“…Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant whose mechanisms of action involve oxidation of endogenous nucleophilic groups (mainly thiols…”
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Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease by Canto, Rômulo F S, Barbosa, Flavio A R, Nascimento, Vanessa, de Oliveira, Aldo S, Brighente, Inês M C, Braga, Antonio Luiz

“…In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for…”
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Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues by Russowsky, Dennis, Canto, Rômulo F.S., Sanches, Sergio A.A., D’Oca, Marcelo G.M., de Fátima, Ângelo, Pilli, Ronaldo A., Kohn, Luciana K., Antônio, Márcia A., de Carvalho, João Ernesto

“…The synthesis and differential antiproliferative activity of monastrol ( 1a), oxo-monastrol ( 1b) and eight oxygenated derivatives 3a, b– 6a, b on seven human…”
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Allylic Selenocyanates as Antifungal Agents Against Pathogenic Candida Species by Bazana, Luana C. G., Carvalho, Ânderson R., Silveira, Gustavo P., S. de Oliveira, Luis Flávio, Teixeira, Mário L., Lopes, William, Vainstein, Marilene H., Barbosa, Flavio A. R., Russo, Theo V. C., Sá, Marcus M., Canto, Rômulo F. S., Fuentefria, Alexandre M.

“…Candida is a genus that causes the highest number of fungal infections on people around the world, responsible for high mortality rates in critical and…”
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Pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats by Torres, Bruna G. S., Uchôa, Flávia De Toni, Pigatto, Maiara C., Azeredo, Francine J., Haas, Sandra E., Dallegrave, Eliane, Canto, Rômulo F. S., Eifler-Lima, Vera L., Dalla Costa, Teresa

“…Abstract 1. The present work investigated the pharmacokinetic and tissue distribution as well as acute toxicity of a new chemical entity (NCE), the anticancer…”
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Direct Synthesis of Allylic Thioethers Under Greener Conditions: A Solvent- and Catalyst-Free Approach by Tabarelli, Greice, Godoi, Marcelo, Canto, Rômulo F. S., Mora, José R., Nome, Faruk, Braga, Antonio L.

“…We present herein a new catalyst-free and solvent-free approach for the synthesis of allylic thioethers directly from allylic alcohols and thiols. The…”
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Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections by Batista, Bruna G., Lana, Daiane F. Dalla, Silveira, Gustavo P., Sá, Marcus M., Ferreira, Misael, Russo, Theo V. C., Canto, Rômulo F. S., Barbosa, Flavio A. R., Braga, Antônio L., Kaminski, Taís F. A., de Oliveira, Luís F. S., Machado, Michel M., Lopes, William, Vainstein, Marilene H., Teixeira, Mário L., Andrade, Saulo F., Fuentefria, Alexandre M.

“…Fusarium is an emerging opportunistic fungal pathogen that causes local or systemic infections. The successful use of a therapeutic drug or combination…”
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Synthesis of limonene beta-amino alcohol derivatives in support of new antileishmanial therapies by Ferrarini, Stela R, Graebin, Cedric S, Limberger, Jones, Canto, Rômulo F S, Dias, Daiane O, Rosa, Ricardo G da, Madeira, Maria de Fátima, Eifler-Lima, Vera L

“…A series of seven limonene beta-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found…”
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Antiproliferative activity and toxicity evaluation of 1,2,3-triazole and 4-methyl coumarin hybrids in the MCF7 breast cancer cell line by Augsten, Lucas Volnei, Göethel, Gabriela, Gauer, Bruna, Feiffer Charão, Mariele, von Poser, Gilsane, Canto, Romulo F. S, Arbo, Marcelo Dutra, Eifler-Lima, Vera Lucia, Garcia, Solange Cristina

“…Four coumarin-triazole hybrids were selected from our in house library and screened for cytotoxic activity on A549 (lung cancer), HepG2 (liver cancer), J774A1…”
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Synthesis of Limonene β-Amino Alcohol Derivatives in Support of New Antileishmanial Therapies by Ferrarini, Stela R, Graebin, Cedric S, Limberger, Jones, Canto, Rômulo F.S, Dias, Daiane O, da Rosa, Ricardo G, Madeira, Maria de Fátima, Eifler-Lima, Vera L

“…A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to…”
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