Search Results - "Cantley, Jennifer"

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers by Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

“…The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4 is frequently mutated in cancer and inactivation results in a cellular dependence on…”
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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance by Cantley, Jennifer L., Yoshimura, Toru, Camporez, Joao Paulo G., Zhang, Dongyan, Jornayvaz, Francois R., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Jurczak, Michael J., Kahn, Mario, Guigni, Bias A., Serr, Julie, Hankin, Joseph, Murphy, Robert C., Cline, Gary W., Bhanot, Sanjay, Manchem, Vara Prasad, Brown, J. Mark, Samuel, Varman T., Shulman, Gerald I.

“…Comparative gene identification 58 (CGI-58) is a lipid droplet-associated protein that promotes the hydrolysis of triglyceride by activating adipose…”
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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance by KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L

“…We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase…”
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Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats by Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.

“…Genome‐wide array studies have associated the patatin‐like phospholipase domain‐containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis. However, it is…”
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Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs by Kou, Ponien, Levy, Elizabeth S, Nguyen, An D, Zhang, Donglu, Chen, Shu, Cui, Yusi, Zhang, Xing, Broccatelli, Fabio, Pizzano, Jennifer, Cantley, Jennifer, Bortolon, Elizabeth, Rousseau, Emma, Berlin, Michael, Dragovich, Peter, Sethuraman, Vijay

“…Proteolysis-Targeting Chimeras (PROTACs) are a promising new technology in drug development. They have rapidly evolved in recent years, with several of them in…”
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Development of a Targeted Urine Proteome Assay for kidney diseases by Cantley, Lloyd G., Colangelo, Christopher M., Stone, Kathryn L., Chung, Lisa, Belcher, Justin, Abbott, Thomas, Cantley, Jennifer L., Williams, Kenneth R., Parikh, Chirag R.

“…Purpose Since human urine is the most readily available biofluid whose proteome changes in response to disease, it is a logical sample for identifying protein…”
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Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats by Cantley, Jennifer L, Vatner, Daniel F, Galbo, Thomas, Madiraju, Anila, Petersen, Max, Perry, Rachel J, Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Gattu, Arijeet K, Stacy, Mitchel R, Dione, Donald P, Sinusas, Albert J, Ragolia, Louis, Hall, Christopher E, Manchem, Vara Prasad, Bhanot, Sanjay, Bogan, Jonathan S, Samuel, Varman T

“…The steroid receptor coactivator 1 (SRC1) regulates key metabolic pathways, including glucose homeostasis. SRC1(-/-) mice have decreased hepatic expression of…”
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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models by Berlin, Michael, Cantley, Jennifer, Bookbinder, Mark, Bortolon, Elizabeth, Broccatelli, Fabio, Cadelina, Greg, Chan, Emily W., Chen, Huifen, Chen, Xin, Cheng, Yunxing, Cheung, Tommy K., Davenport, Kim, DiNicola, Dean, Gordon, Debbie, Hamman, Brian D., Harbin, Alicia, Haskell, Roy, He, Mingtao, Hole, Alison J., Januario, Thomas, Kerry, Philip S., Koenig, Stefan G., Li, Limei, Merchant, Mark, Pérez-Dorado, Inmaculada, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Soto, Leofal, Staben, Leanna R., Sun, Hongming, Tian, Qingping, Wang, Jing, Wang, Weifeng, Ye, Crystal S., Ye, Xiaofen, Zhang, Penghong, Zhou, Yuhui, Yauch, Robert, Dragovich, Peter S.

“…The identification of VHL-binding proteolysis targeting chimeras (PROTACs) that potently degrade the BRM protein (also known as SMARCA2) in SW1573 cell-based…”
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Abstract 5687: Selective, chemically-induced degradation of BRM ( SMARCA2 ) enables in vivo efficacy in BRG1 ( SMARCA4 )-deficient xenograft tumor models by Berlin, Michael, Cantley, Jennifer, Wang, Jing, Bookbinder, Mark, Cadelina, Gregory, Chan, Emily, Chen, Huifen, Chen, Xin, Davenport, Kim, Fernando, Tharu, Gordon, Debbie, Hamman, Brian, Haskell, Roy, Ishchenko, Alexey, Kirkpatrick, Donald S., Maher, Jonathan, Merchant, Mark, Moffat, John, Morgan, Alicia, Nguyen, An, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Sethuraman, Vijay, Staben, Leanna, Wilson, Catherine, Ye, Xiaofen, Broccatelli, Fabio, Yauch, Robert, Dragovich, Peter S.

“…Abstract The mammalian SWI/SNF complex catalyzes the remodeling of chromatin through the helicase activity of two mutually-exclusive, paralogous subunits, BRG1…”
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Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring by Rauniyar, Navin, Yu, Xiaoqing, Cantley, Jennifer, Voss, Edward Z., Belcher, Justin, Colangelo, Christopher M., Stone, Kathryn L., Dahl, Neera, Parikh, Chirag, Lam, TuKiet T., Cantley, Lloyd G.

“…Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a life‐long disease in which the genes responsible are known, but the pathogenesis of cyst…”
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