Search Results - "Cantini, Francesca"

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants by Luchinat, Enrico, Barbieri, Letizia, Rubino, Jeffrey T., Kozyreva, Tatiana, Cantini, Francesca, Banci, Lucia

“…Mutations in the superoxide dismutase 1 (SOD1) gene are related to familial cases of amyotrophic lateral sclerosis (fALS). Here we exploit in-cell NMR to…”
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Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) by Banci, Lucia, Bertini, Ivano, Cantini, Francesca, Kozyreva, Tatiana, Massagni, Chiara, Palumaa, Peep, Rubino, Jeffrey T, Zovo, Kairit

“…Copper chaperone for superoxide dismutase 1 (SOD1), CCS, is the physiological partner for the complex mechanism of SOD1 maturation. We report an in vitro model…”
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CIAO3 protein forms a stable ternary complex with two key players of the human cytosolic iron–sulfur cluster assembly machinery by Maione, Vincenzo, Grifagni, Deborah, Torricella, Francesco, Cantini, Francesca, Banci, Lucia

“…The CIAO3 protein operates at a crossroad of the cytosolic iron–sulfur protein assembly (CIA) machinery. Although the functional role of CIAO3 has been…”
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A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels by Saponaro, Andrea, Cantini, Francesca, Porro, Alessandro, Bucchi, Annalisa, DiFrancesco, Dario, Maione, Vincenzo, Donadoni, Chiara, Introini, Bianca, Mesirca, Pietro, Mangoni, Matteo E, Thiel, Gerhard, Banci, Lucia, Santoro, Bina, Moroni, Anna

“…Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their…”
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1H, 13C and 15N assignment of self-complemented MrkA protein antigen from Klebsiella pneumoniae by Monaci, Valentina, Gasperini, Gianmarco, Banci, Lucia, Micoli, Francesca, Cantini, Francesca

“…Klebsiella pneumoniae (Kp) poses an escalating threat to public health, particularly given its association with nosocomial infections and its emergence as a…”
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Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut by Dubiela, Pawel, Del Conte, Rebecca, Cantini, Francesca, Borowski, Tomasz, Aina, Roberta, Radauer, Christian, Bublin, Merima, Hoffmann-Sommergruber, Karin, Alessandri, Stefano

“…Plant non-specific lipid transfer proteins type 1 (nsLTP1) are small basic proteins with a hydrophobic cavity able to host a number of different ligands: i.e…”
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1H, 13C and 15N assignment of the human mitochondrial paramagnetic iron–sulfur protein CISD3 by Silva, José Malanho, Grifagni, Deborah, Cantini, Francesca, Piccioli, Mario

“…CISD3 is a mitochondrial protein that contains two [2Fe–2S] clusters. This protein is overexpressed in some types of cancer, so it has emerged as a potential…”
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Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction by Dubiela, Pawel, Aina, Roberta, Polak, Dominika, Geiselhart, Sabine, Humeniuk, Piotr, Bohle, Barbara, Alessandri, Stefano, Del Conte, Rebecca, Cantini, Francesca, Borowski, Tomasz, Bublin, Merima, Hoffmann-Sommergruber, Karin

“…[...]whether the apo- or holoform of Pru p 3 has an impact on the IgE-binding activity is yet unknown. [...]we studied a range of saturated and…”
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Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function by Saponaro, Andrea, Pauleta, Sofia R., Cantini, Francesca, Matzapetakis, Manolis, Hammann, Christian, Donadoni, Chiara, Hu, Lei, Thiel, Gerhard, Banci, Lucia, Santoro, Bina, Moroni, Anna

“…Significance cAMP regulation of ion channels controls higher brain functions, such as sleep, memory, and cognition. Hyperpolarization-activated cyclic…”
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The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication by Bianconi, Elisa, Gidari, Anna, Souma, Maria, Sabbatini, Samuele, Grifagni, Deborah, Bigiotti, Carlo, Schiaroli, Elisabetta, Comez, Lucia, Paciaroni, Alessandro, Cantini, Francesca, Francisci, Daniela, Macchiarulo, Antonio

“…Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune…”
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Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies by Elia, Francesco, Cantini, Francesca, Chiti, Fabrizio, Dobson, Christopher Martin, Bemporad, Francesco

“…The acylphosphatase from Sulfolobus solfataricus (Sso AcP) is a globular protein able to aggregate in vitro from a native-like conformational ensemble without…”
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In-cell NMR in E. coli to monitor maturation steps of hSOD1 by Banci, Lucia, Barbieri, Letizia, Bertini, Ivano, Cantini, Francesca, Luchinat, Enrico

“…In-cell NMR allows characterizing the folding state of a protein as well as posttranslational events at molecular level, in the cellular context. Here, the…”
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An NMR Study of the Interaction of the N-terminal Cytoplasmic Tail of the Wilson Disease Protein with Copper(I)-HAH1 by Banci, Lucia, Bertini, Ivano, Cantini, Francesca, Massagni, Chiara, Migliardi, Manuele, Rosato, Antonio

“…ATP7B is a human P1B-type ATPase that has a crucial role in maintaining copper(I) homeostasis. Mutations in the corresponding gene are the cause of Wilson…”
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Structural and Dynamic Aspects Related to Oligomerization of Apo SOD1 and Its Mutants by Banci, Lucia, Bertini, Ivano, Boca, Mirela, Calderone, Vito, Cantini, Francesca, Girotto, Stefania, Vieru, Miguela, Gronenborn, Angela M.

“…The structural and dynamical properties of the metal-free form of WT human superoxide dismutase 1 (SOD1) and its familial amyotrophic lateral sclerosis…”
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Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins by Cafardi, Valeria, Biagini, Massimiliano, Martinelli, Manuele, Leuzzi, Rosanna, Rubino, Jeffrey T, Cantini, Francesca, Norais, Nathalie, Scarselli, Maria, Serruto, Davide, Unnikrishnan, Meera

“…Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial…”
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Resonance assignments of cytochrome MtoD from the extracellular electron uptake pathway of sideroxydans lithotrophicus ES-1 by Coelho, Anaísa, Silva, José M., Cantini, Francesca, Piccioli, Mario, Louro, Ricardo O., Paquete, Catarina M.

“…The contribution of Fe(II)-oxidizing bacteria to iron cycling in freshwater, groundwater, and marine environments has been widely recognized in recent years…”
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The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction by Bertini, Ivano, Banci, Lucia, Cantini, Francesca, Felli, Isabella C, Gonnelli, Leonardo, Hadjiliadis, Nick, Pierattelli, Roberta, Rosato, Antonio, Voulgaris, Petros

“…Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling…”
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Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs by Massai, Lara, Grifagni, Deborah, De Santis, Alessia, Geri, Andrea, Cantini, Francesca, Calderone, Vito, Banci, Lucia, Messori, Luigi

“…Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound…”
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In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants by Luchinat, Enrico, Barbieri, Letizia, Rubino, Jeffrey T., Kozyreva, Tatiana, Cantini, Francesca, Banci, Lucia

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2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19 by Cantini, Francesca, Andreano, Emanuele, Paciello, Ida, Ghini, Veronica, Berti, Francesco, Rappuoli, Rino, Banci, Lucia

“…The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D 1H-13C ALSOFAST-HMQC…”
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