Role of Vitamin D in Children With Hepatosteatosis

Role of Vitamin D in Children With Hepatosteatosis

ABSTRACT Background: The increasing incidence of obesity in children is a significant risk factor for nonalcoholic fatty liver disease and obesity‐associated morbidity. Vitamin D has a major role in bone mineral metabolism and has antimicrobial, antioxidant properties. In this study we aimed to inve...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric gastroenterology and nutrition Vol. 59; no. 1; pp. 106 - 111
Main Authors: Yildiz, Ismail, Erol, Oguz B., Toprak, Sadik, Cantez, Mustafa S., Omer, Beyhan, Kilic, Ayse, Oguz, Fatma, Uysalol, Metin, Yekeler, Ensar, Unuvar, Emin
Format: Journal Article
Language:English
Published: United States 01-07-2014
Subjects:
Adolescent
Alkaline Phosphatase - blood
Arabidopsis Proteins - blood
Body Mass Index
Calcium - blood
Case-Control Studies
Child
Child, Preschool
Female
hepatosteatosis
Humans
Insulin Resistance
Male
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnostic imaging
obesity
Obesity - blood
Obesity - complications
Parathyroid Hormone - blood
Severity of Illness Index
Sex Factors
Ultrasonography
vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Waist Circumference
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background: The increasing incidence of obesity in children is a significant risk factor for nonalcoholic fatty liver disease and obesity‐associated morbidity. Vitamin D has a major role in bone mineral metabolism and has antimicrobial, antioxidant properties. In this study we aimed to investigate the role of vitamin D in children with obesity with hepatosteatosis. Methods: A total of 101 children with obesity were included in this study. Hepatosteatosis was diagnosed and graded using ultrasonography. Serum levels of 25‐hydroxyvitamin D (25‐(OH) vitamin D), calcium, phosphate, alkaline phosphatase, and parathormone were tested. Two‐sided t test and Pearson χ2 tests were used for the relation between vitamin D and hepatosteatosis. Results: In our study group, 45.5% were girls (n = 46) and the mean age was 11.5 ± 2.8 years (range 3–17 years). Hepatosteatosis was identified in 58 children (57.4%). The diagnosis of grade 1 and grade 2 hepatosteatosis was made in 41 (40.6%) and 17 (16.8%) children, respectively. Median serum 25‐(OH) vitamin D levels in children without hepatosteatosis was 16.4 ng/mL (interquartile range 12.4–24.8 ng/mL), whereas children with grade 1 and grade 2 hepatosteatosis had 25‐(OH) vitamin D levels of 14.2 ng/mL (interquartile range 9.5–21.2 ng/mL) and 11.5 ng/mL (interquartile range 7.5–16.7 ng/mL), respectively (P = 0.005). There was a positive correlation between insulin resistance and the grade of hepatosteatosis (P = 0.03). Conclusions: Serum vitamin D levels in children with obesity with hepatosteatosis are significantly lower than vitamin D levels in children with obesity without hepatosteatosis. In this observational study we only refer to the association of vitamin D deficiency/insufficiency with hepatosteatosis.
Bibliography:The authors report no conflicts of interest.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
ISSN:0277-2116
1536-4801
DOI:10.1097/MPG.0000000000000371