Search Results - "Cantalupo, Sueva"

Genetic Predisposition to Solid Pediatric Cancers by Capasso, Mario, Montella, Annalaura, Tirelli, Matilde, Maiorino, Teresa, Cantalupo, Sueva, Iolascon, Achille

“…Progresses over the past years have extensively improved our capacity to use genome-scale analyses—including high-density genotyping and exome and genome…”
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HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia by Cimmino, Flora, Avitabile, Marianna, Lasorsa, Vito Alessandro, Montella, Annalaura, Pezone, Lucia, Cantalupo, Sueva, Visconte, Feliciano, Corrias, Maria Valeria, Iolascon, Achille, Capasso, Mario

“…HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct…”
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Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19 by Cantalupo, Sueva, Lasorsa, Vito Alessandro, Russo, Roberta, Andolfo, Immacolata, D’Alterio, Giuseppe, Rosato, Barbara Eleni, Frisso, Giulia, Abete, Pasquale, Cassese, Gian Marco, Servillo, Giuseppe, Gentile, Ivan, Piscopo, Carmelo, Della Monica, Matteo, Fiorentino, Giuseppe, Russo, Giuseppe, Cerino, Pellegrino, Buonerba, Carlo, Pierri, Biancamaria, Zollo, Massimo, Iolascon, Achille, Capasso, Mario

“…Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role…”
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Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations by Pastorino, Fabio, Capasso, Mario, Brignole, Chiara, Giglio, Serena, Bensa, Veronica, Cantalupo, Sueva, Lasorsa, Vito Alessandro, Tondo, Annalisa, Mura, Rossella, Sementa, Angela Rita, Garaventa, Alberto, Ponzoni, Mirco, Amoroso, Loredana

“…Neuroblastoma (NB) is the most common extracranial solid tumor encountered in childhood. Although there has been significant improvement in the outcomes of…”
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Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19 by Andolfo, Immacolata, Russo, Roberta, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Rosato, Barbara Eleni, Bonfiglio, Ferdinando, Frisso, Giulia, Abete, Pasquale, Cassese, Gian Marco, Servillo, Giuseppe, Esposito, Gabriella, Gentile, Ivan, Piscopo, Carmelo, Villani, Romolo, Fiorentino, Giuseppe, Cerino, Pellegrino, Buonerba, Carlo, Pierri, Biancamaria, Zollo, Massimo, Iolascon, Achille, Capasso, Mario

“…The established risk factors of coronavirus disease 2019 (COVID-19) are advanced age, male sex, and comorbidities, but they do not fully explain the wide…”
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Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics by Montella, Annalaura, Cantalupo, Sueva, D'Alterio, Giuseppe, Damiano, Vincenzo, Iolascon, Achille, Capasso, Mario

“…Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites,…”
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FGFR1 is a potential therapeutic target in neuroblastoma by Cimmino, Flora, Montella, Annalaura, Tirelli, Matilde, Avitabile, Marianna, Lasorsa, Vito Alessandro, Visconte, Feliciano, Cantalupo, Sueva, Maiorino, Teresa, De Angelis, Biagio, Morini, Martina, Castellano, Aurora, Locatelli, Franco, Capasso, Mario, Iolascon, Achille

“…FGFR1 regulates cell-cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1…”
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From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models by Capasso, Mario, Brignole, Chiara, Lasorsa, Vito A, Bensa, Veronica, Cantalupo, Sueva, Sebastiani, Enrico, Quattrone, Alessandro, Ciampi, Eleonora, Avitabile, Marianna, Sementa, Angela R, Mazzocco, Katia, Cafferata, Barbara, Gaggero, Gabriele, Vellone, Valerio G, Cilli, Michele, Calarco, Enzo, Giusto, Elena, Perri, Patrizia, Aveic, Sanja, Fruci, Doriana, Tondo, Annalisa, Luksch, Roberto, Mura, Rossella, Rabusin, Marco, De Leonardis, Francesco, Cellini, Monica, Coccia, Paola, Iolascon, Achille, Corrias, Maria V, Conte, Massimo, Garaventa, Alberto, Amoroso, Loredana, Ponzoni, Mirco, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Although the overall survival of patients with NB…”
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Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma by Cimmino, Flora, Avitabile, Marianna, Lasorsa, Vito Alessandro, Pezone, Lucia, Cardinale, Antonella, Montella, Annalaura, Cantalupo, Sueva, Iolascon, Achille, Capasso, Mario

“…is associated with the development of high-risk neuroblastoma patients. Particularly, the expression of full length (FL) isoform, FL , correlates to high-risk…”
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CFDP1 is a neuroblastoma susceptibility gene that regulates transcription factors of the noradrenergic cell identity by Formicola, Daniela, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Testori, Alessandro, Cardinale, Antonella, Avitabile, Marianna, Diskin, Sharon, Iolascon, Achille, Capasso, Mario

“…Pleiotropic genetic factors (e.g., DNA polymorphisms) may be involved in the initiation of neuroblastoma (NB) and coronary artery disease (CAD) given their…”
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Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways by Avitabile, Marianna, Bonfiglio, Ferdinando, Aievola, Vincenzo, Cantalupo, Sueva, Maiorino, Teresa, Lasorsa, Vito Alessandro, Domenicotti, Cinzia, Marengo, Barbara, Zbyněk, Heger, Vojtěch, Adam, Iolascon, Achille, Capasso, Mario

“…[Display omitted] High-Risk neuroblastoma (NB) survival rate is still <50%, despite treatments being more and more aggressive. The biggest hurdle liable to…”
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Integrative genomic analyses identify neuroblastoma risk genes involved in neuronal differentiation by Tirelli, Matilde, Bonfiglio, Ferdinando, Cantalupo, Sueva, Montella, Annalaura, Avitabile, Marianna, Maiorino, Teresa, Diskin, Sharon J., Iolascon, Achille, Capasso, Mario

“…Genome-Wide Association Studies (GWAS) have been decisive in elucidating the genetic predisposition of neuroblastoma (NB). The majority of genetic variants…”
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Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma by Lasorsa, Vito Alessandro, Montella, Annalaura, Cantalupo, Sueva, Tirelli, Matilde, de Torres, Carmen, Aveic, Sanja, Tonini, Gian Paolo, Iolascon, Achille, Capasso, Mario

“…Noncoding cis-regulatory variants have gained interest as cancer drivers, yet progress in understanding their significance is hindered by the numerous…”
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Transcription Factors Involved in Tumorigenesis Are Over-Represented in Mutated Active DNA-Binding Sites in Neuroblastoma by Capasso, Mario, Lasorsa, Vito Alessandro, Cimmino, Flora, Avitabile, Marianna, Cantalupo, Sueva, Montella, Annalaura, De Angelis, Biagio, Morini, Martina, de Torres, Carmen, Castellano, Aurora, Locatelli, Franco, Iolascon, Achille

“…The contribution of coding mutations to oncogenesis has been largely clarified, whereas little is known about somatic mutations in noncoding DNA and their role…”
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Exploring the role of HLA variants in neuroblastoma susceptibility through whole exome sequencing by Bonfiglio, Ferdinando, Lasorsa, Vito Alessandro, Aievola, Vincenzo, Cantalupo, Sueva, Morini, Martina, Ardito, Martina, Conte, Massimo, Fragola, Martina, Eva, Alessandra, Corrias, Maria Valeria, Iolascon, Achille, Capasso, Mario

“…Although a number of susceptibility loci for neuroblastoma (NB) have been identified by genome‐wide association studies, it is still unclear whether variants…”
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Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication by de Antonellis, Pasqualino, Ferrucci, Veronica, Miceli, Marco, Bibbo, Francesca, Asadzadeh, Fatemeh, Gorini, Francesca, Mattivi, Alessia, Boccia, Angelo, Russo, Roberta, Andolfo, Immacolata, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Fusco, Giovanna, Viscardi, Maurizio, Brandi, Sergio, Cerino, Pellegrino, Monaco, Vittoria, Choi, Dong-Rac, Cheong, Jae-Ho, Iolascon, Achille, Amente, Stefano, Monti, Maria, Fava, Luca L, Capasso, Mario, Kim, Hong-Yeoul, Zollo, Massimo

“…ATP2B1 is a known regulator of calcium (Ca 2+ ) cellular export and homeostasis. Diminished levels of intracellular Ca 2+ content have been suggested to impair…”
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Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene by Avitabile, Marianna, Succoio, Mariangela, Testori, Alessandro, Cardinale, Antonella, Vaksman, Zalman, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Esposito, Matteo, Cimmino, Flora, Montella, Annalaura, Formicola, Daniela, Koster, Jan, Andreotti, Virginia, Ghiorzo, Paola, Romano, Maria Fiammetta, Staibano, Stefania, Scalvenzi, Massimiliano, Ayala, Fabrizio, Hakonarson, Hakon, Corrias, Maria Valeria, Devoto, Marcella, Law, Matthew H, Iles, Mark M, Brown, Kevin, Diskin, Sharon, Zambrano, Nicola, Iolascon, Achille, Capasso, Mario

“…Abstract Neuroblastoma (NB) and malignant cutaneous melanoma (CMM) are neural crest cells (NCC)-derived tumors and may have a shared genetic basis, but this…”
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Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1 by Cardinale, Antonella, Cantalupo, Sueva, Lasorsa, Vito Alessandro, Montella, Annalaura, Cimmino, Flora, Succoio, Mariangela, Vermeulen, Michiel, Baltissen, Marijke P, Esposito, Matteo, Avitabile, Marianna, Formicola, Daniela, Testori, Alessandro, Bonfiglio, Ferdinando, Ghiorzo, Paola, Scalvenzi, Massimiliano, Ayala, Fabrizio, Zambrano, Nicola, Iles, Mark M, Xu, Mai, Law, Matthew H, Brown, Kevin M, Iolascon, Achille, Capasso, Mario

“…Abstract The 10q24.33 locus is known to be associated with susceptibility to cutaneous malignant melanoma (CMM), but the mechanisms underlying this association…”
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Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals by D’Alterio, Giuseppe, Lasorsa, Vito Alessandro, Bonfiglio, Ferdinando, Cantalupo, Sueva, Rosato, Barbara Eleni, Andolfo, Immacolata, Russo, Roberta, Esposito, Umberto, Frisso, Giulia, Abete, Pasquale, Cassese, Gian Marco, Servillo, Giuseppe, Gentile, Ivan, Piscopo, Carmelo, Della Monica, Matteo, Fiorentino, Giuseppe, Boccia, Angelo, Paolella, Giovanni, Ferrucci, Veronica, de Antonellis, Pasqualino, Siciliano, Roberto, Asadzadeh, Fathem, Cerino, Pellegrino, Buonerba, Carlo, Pierri, Biancamaria, Zollo, Massimo, Iolascon, Achille, Capasso, Mario

“…Emerging evidence suggest that infection-dependent hyperactivation of complement system (CS) may worsen COVID-19 outcome. We investigated the role of predicted…”
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Association of PARP1 polymorphisms with response to chemotherapy in patients with high‐risk neuroblastoma by Avitabile, Marianna, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Cardinale, Antonella, Cimmino, Flora, Montella, Annalaura, Capasso, Dalila, Haupt, Riccardo, Amoroso, Loredana, Garaventa, Alberto, Quattrone, Alessandro, Corrias, Maria Valeria, Iolascon, Achille, Capasso, Mario

“…The genetic aetiology and the molecular mechanisms that characterize high‐risk neuroblastoma are still little understood. The majority of high‐risk…”
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