Search Results - "Cano‐Sánchez, Patricia"
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Decoding the mechanism governing the structural stability of wheat germ agglutinin and its isolated domains: A combined calorimetric, NMR, and MD simulation study
Published in Protein science (01-06-2024)“…Wheat germ agglutinin (WGA) demonstrates potential as an oral delivery agent owing to its selective binding to carbohydrates and its capacity to traverse…”
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Molecular and functional characterization of a glycosylated Galactose-Binding lectin from Mytilus californianus
Published in Fish & shellfish immunology (01-07-2017)“…Lectins play crucial roles for innate immune responses in invertebrates by recognizing and eliminating pathogens. In this study, a lectin from the mussel…”
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A biophysical and structural study of two chitinases from Agave tequilana and their potential role as defense proteins
Published in The FEBS journal (01-12-2019)“…Plant chitinases are enzymes that have several functions, including providing protection against pathogens. Agave tequilana is an economically important plant…”
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Successful refolding and NMR structure of rMagi3: A disulfide‐rich insecticidal spider toxin
Published in Protein science (01-03-2018)“…The need for molecules with high specificity against noxious insects leads the search towards spider venoms that have evolved highly selective toxins for…”
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Bacterial expression, purification and biophysical characterization of wheat germ agglutinin and its four hevein‐like domains
Published in Biopolymers (01-01-2019)“…Wheat germ agglutinin (WGA), a chitin binding lectin, has attracted increasing interest because of its unique characteristics such as conformational stability,…”
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Comparative study of two GH19 chitinase‐like proteins from Hevea brasiliensis, one exhibiting a novel carbohydrate‐binding domain
Published in The FEBS journal (01-10-2014)“…Plants express chitinase and chitinase‐like proteins (CLPs) belonging to the glycosyl hydrolases of the GH18 and GH19 families, which exhibit varied functions…”
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New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation
Published in Bioinorganic chemistry and applications (25-10-2023)“…Organotin complexes were prepared through a one-pot reaction with three components by reacting thiosemicarbazide or 4-methyl-3-thiosemicarbazide or…”
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Cytotoxicity of Recombinant Tamapin and Related Toxin-Like Peptides on Model Cell Lines
Published in Chemical research in toxicology (16-06-2014)“…The scorpion toxin tamapin displays the most potent and selective blockage against KCa2.2 channels known to date. In this work, we report the biosynthesis,…”
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Structural and functional studies of scorpine: A channel blocker and cytolytic peptide
Published in Toxicon (Oxford) (15-01-2023)“…Scorpine is an antimicrobial and antimalarial peptide isolated from Pandinus imperator scorpion venom. As there are few functional and structural studies…”
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Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs
Published in FEBS letters (01-08-2024)“…Tyrosine protein phosphatase non‐receptor type 1 (PTP1B; also known as protein tyrosine phosphatase 1B) is a member of the protein tyrosine phosphatase (PTP)…”
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Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents
Published in Journal of biomolecular structure & dynamics (13-04-2022)“…We study the CaM-peptide interactions for four CaM-related peptides with different calcium equivalents, using the hCaM-M124C-mBBr biosensor and Molecular…”
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Hydroxy-neo-Clerodanes and 5,10-seco-neo-Clerodanes from Salvia decora
Published in Journal of natural products (Washington, D.C.) (24-07-2020)“…Preliminary analysis of the mass spectrometric (MS) and NMR spectroscopic data of the primary fractions from the biologically active extract of Salvia decora…”
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Solution structure and antiparasitic activity of scorpine‐like peptides from Hoffmannihadrurus gertschi
Published in FEBS letters (01-07-2016)“…Scorpine‐like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel‐blocking…”
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A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity
Published in Communications biology (27-07-2022)“…Allergies have become a rising health problem, where plentiful substances can trigger IgE-mediated allergies in humans. While profilins are considered minor…”
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The B Subunit of PirABvp Toxin Secreted from Vibrio parahaemolyticus Causing AHPND Is an Amino Sugar Specific Lectin
Published in Pathogens (Basel) (03-03-2020)“…Vibrio parahaemolyticus (Vp) is the etiological agent of the acute hepatopancreatic necrosis disease (AHPND) in Penaeus vannamei shrimp. Vp possesses a 63–70…”
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Application of a Fluorescent Biosensor in Determining the Binding of 5-HT to Calmodulin
Published in Chemosensors (01-09-2021)“…Here, we show the utility of the fluorescent biosensor hCaM-M124C-mBBr in detecting and determining the affinity of serotonin (5-HT). We obtained a Kd of 5-HT…”
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Plasticity of 5‐HT1A receptor‐mediated signaling during early postnatal brain development
Published in Journal of neurochemistry (01-05-2007)“…The presence of serotonin 1A receptor (5‐HT1A‐R) in the hippocampus, amygdala, and most regions of the frontal cortex is essential between postnatal day‐5–21…”
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Use of the SOS-chromotest spot assay as a screening system for detecting genotoxic compounds in crude plant extracts
Published in Alternatives to laboratory animals (2002)“…An SOS-chromotest spot assay was used to detect genotoxic compounds in crude plant extracts. The method allows simultaneous testing of extracts from different…”
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Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
Published in Revista brasileira de farmacognosia (01-06-2024)“…Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued alerts…”
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Structural insights into the IgE mediated responses induced by the allergens Hev b 8 and Zea m 12 in their dimeric forms
Published in Scientific reports (02-09-2016)“…Oligomerization of allergens plays an important role in IgE-mediated reactions, as effective crosslinking of IgE- FcεRI complexes on the cell membrane is…”
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