Search Results - "Cano, Jose Paya"

Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains by Parsons, Michael J, Grimm, Christina, Paya-Cano, Jose L, Fernandes, Cathy, Liu, Lin, Philip, Vivek M, Chesler, Elissa J, Nietfeld, Wilfried, Lehrach, Hans, Schalkwyk, Leonard C

“…miRNAs are short single-stranded non-coding RNAs involved in post-transcriptional gene regulation that play a major role in normal biological functions and…”
Get full text

DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice by Pidsley, Ruth, Fernandes, Cathy, Viana, Joana, Paya-Cano, Jose L, Liu, Lin, Smith, Rebecca G, Schalkwyk, Leonard C, Mill, Jonathan

“…Insulin-like growth factor 2 (Igf2) is a paternally expressed imprinted gene regulating fetal growth, playing an integral role in the development of many…”
Get full text

Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour by Fernandes, Cathy, Paya-Cano, Jose L., Sluyter, Frans, D'Souza, Ursula, Plomin, Robert, Schalkwyk, Leonard C.

“…Mouse inbred strains differ in many aspects of their phenotypes, and it is known that gene expression does so too. This gives us an opportunity to isolate the…”
Get full text

Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish by Malki, Karim, Du Rietz, Ebba, Crusio, Wim E., Pain, Oliver, Paya-Cano, Jose, Karadaghi, Rezhaw L., Sluyter, Frans, de Boer, Sietse F., Sandnabba, Kenneth, Schalkwyk, Leonard C., Asherson, Philip, Tosto, Maria Grazia

“…Despite moderate heritability estimates, the molecular architecture of aggressive behavior remains poorly characterized. This study compared gene expression…”
Get full text

Development of multivariable models to predict change in Body Mass Index within a clinical trial population of psychotic individuals by Harrison, Rebecca N. S., Gaughran, Fiona, Murray, Robin M., Lee, Sang Hyuck, Cano, Jose Paya, Dempster, David, Curtis, Charles J., Dima, Danai, Patel, Hamel, de Jong, Simone, Breen, Gerome

“…Many antipsychotics promote weight gain, which can lead to non-compliance and relapse of psychosis. By developing models that accurately identify individuals…”
Get full text

Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice by Janecka, Magdalena, Marzi, Sarah J., Parsons, Michael J., Liu, Lin, Paya-Cano, Jose L., Smith, Rebecca G., Fernandes, Cathy, Schalkwyk, Leonard C.

“…Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is…”
Get full text

Tissue-specific patterns of allelically-skewed DNA methylation by Marzi, Sarah J., Meaburn, Emma L., Dempster, Emma L., Lunnon, Katie, Paya-Cano, Jose L., Smith, Rebecca G., Volta, Manuela, Troakes, Claire, Schalkwyk, Leonard C., Mill, Jonathan

“…While DNA methylation is usually thought to be symmetrical across both alleles, there are some notable exceptions. Genomic imprinting and X chromosome…”
Get full text

Gene-expression analysis of clozapine treatment in whole blood of patients with psychosis by Harrison, Rebecca N.S, Murray, Robin M, Lee, Sang Hyuck, Paya Cano, Jose, Dempster, David, Curtis, Charles J, Dima, Danai, Gaughran, Fiona, Breen, Gerome, de Jong, Simone

“…OBJECTIVESClozapine is an atypical antipsychotic primarily prescribed for treatment-resistant schizophrenia. We tested the specific effect of clozapine versus…”
Get full text

Antidepressants and the resilience to early-life stress in inbred mouse strains by Binder, Elke, Malki, Karim, Paya-Cano, Jose L, Fernandes, Cathy, Aitchison, Katherine J, Mathé, Aleksander A, Sluyter, Frans, Schalkwyk, Leonard C

“…RATIONALESelecting an effective treatment for patients with major depressive disorder is a perpetual problem for psychiatrists. It is of particular interest to…”
Get full text

Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice by Galsworthy, Michael J, Paya-Cano, Jose L, Liu, Lin, Monleón, Santiago, Gregoryan, Gregory, Fernandes, Cathy, Schalkwyk, Leonard C, Plomin, Robert

“…This report includes the first sibling study of mouse behavior, and presents evidence for a heritable general cognitive ability (g) factor influencing…”
Get full text

Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains by Malki, Karim, Campbell, James, Davies, Matthew, Keers, Robert, Uher, Rudolf, Ward, Malcolm, Paya-Cano, Jose, Aitchinson, Katherine J., Binder, Elke, Sluyter, Frans, Kuhn, Karsten, Selzer, Stefan, Craig, Ian, McGuffin, Peter, Schalkwyk, Leonard C.

“…In this study, we present a pharmacoproteomic investigation of response to antidepressants two inbred strains. Our aim was to uncover molecular mechanisms…”
Get full text

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function by Parsons, Michael J, Grimm, Christina H, Paya-Cano, Jose L, Sugden, Karen, Nietfeld, Wilfried, Lehrach, Hans, Schalkwyk, Leonard C

“…Micro-RNAs (miRNAs) are short, single-stranded, noncoding RNAs that are involved in the regulation of protein-coding genes at the level of messenger RNA…”
Get full text

Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families by Gadelha, Ary, Ota, Vanessa Kiyomi, Cano, Jose Paya, Melaragno, Maria Isabel, Smith, Marilia A C, de Jesus Mari, Jair, Bressan, Rodrigo A, Belangero, Sintia Iole, Breen, Gerome

“…We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report…”
Get full text

Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression by Malki, Karim, Lourdusamy, Anbarasu, Binder, Elke, Payá-Cano, Jose, Sluyter, Frans, Craig, Ian, Keers, Robert, McGuffin, Peter, Uher, Rudolf, Schalkwyk, Leonard C

“…RATIONALEMonoaminergic imbalances play a role in the pathogenesis of depression and most common antidepressant drugs act on monoamine neurotransmitters…”
Get full text

Behavioural battery testing: Evaluation and behavioural outcomes in 8 inbred mouse strains by Lad, Heena Vanmalibhai, Liu, Lin, Paya-Cano, Jose Luis, Parsons, Michael James, Kember, Rachel, Fernandes, Cathy, Schalkwyk, Leonard Cornelis

“…Abstract The use of large scale behavioural batteries for the discovery of novel genes underlying behavioural variation has considerable potential. Building a…”
Get full text

Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis by de Jong, Simone, Newhouse, Stephen J., Patel, Hamel, Lee, Sanghyuck, Dempster, David, Curtis, Charles, Paya-Cano, Jose, Murphy, Declan, Wilson, C. Ellie, Horder, Jamie, Mendez, M. Andreina, Asherson, Philip, Rivera, Margarita, Costello, Helen, Maltezos, Stefanos, Whitwell, Susannah, Pitts, Mark, Tye, Charlotte, Ashwood, Karen L., Bolton, Patrick, Curran, Sarah, McGuffin, Peter, Dobson, Richard, Breen, Gerome

“…Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology. To systematically investigate genomics overlap…”
Get full text

Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping by Lad, Heena V, Liu, Lin, Payá-Cano, José L, Fernandes, Cathy, Schalkwyk, Leonard C

“…Immobility in the tail suspension test (TST) is considered a model of despair in a stressful situation, and acute treatment with antidepressants reduces…”
Get full text

Genes and Gene Networks Implicated in Aggression Related Behaviour by Malki, Karim, Pain, Oliver, Du Rietz, Ebba, Tosto, Maria Grazia, Paya-Cano, Jose, Sandnabba, Kenneth N., de Boer, Sietse, Schalkwyk, Leonard C., Sluyter, Frans

“…Aggressive behaviour is a major cause of mortality and morbidity. Despite of moderate heritability estimates, progress in identifying the genetic factors…”
Get full text

Effect of anosmia on the behavior of standard non-aggressive male mice opponents during agonistic encounters by Calvo-Torrent, Angels, Paya-Cano, Jose Luis, Martinez, Manuela

“…This study assessed whether the differences observed in a previous experiment [Martinez M, Salvador A, Simon VM (1994): Aggressive Behavior 20:441–451] in the…”
Get full text

Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants by Malki, Karim, Uher, Rudolf, Paya-Cano, Jose, Binder, Elke, Rietschel, Marcella, Zobel, Astrid, Mors, Ole, Hauser, Joanna, Henigsberg, Neven, Jerman, Borut, Souery, Daniel, Placentino, Anna, Ng, Mandy Y, Cohen-Woods, Sarah, Sluyter, Frans, Farmer, Anne, Aitchison, Katherine J, Craig, Ian W, Lewis, Cathryn M, McGuffin, Peter, Schalkwyk, Leonard C

“…Background Antidepressant drugs are used as first-line treatment in depression, but response has been shown to be highly heterogeneous, with drugs often…”
Get full text