Search Results - "Canning, Christine M"

Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients by Brusic, Ana, Hainz, Ursula, Wadleigh, Martha, Neuberg, Donna, Su, Mei, Canning, Christine M., DeAngelo, Daniel J., Stone, Richard M., Lee, Jeng-Shin, Mulligan, Richard C., Ritz, Jerome, Dranoff, Glenn, Sasada, Tetsuro, Wu, Catherine J.

“…BCR-ABL + K562 cells hold clinical promise as a component of cancer vaccines, either as bystander cells genetically modified to express immunostimulatory…”
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Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion by Bachireddy, Pavan, Hainz, Ursula, Rooney, Michael, Pozdnyakova, Olga, Aldridge, Julie, Zhang, Wandi, Liao, Xiaoyun, Hodi, F. Stephen, O'Connell, Karyn, Haining, W. Nicholas, Goldstein, Natalie R., Canning, Christine M., Soiffer, Robert J., Ritz, Jerome, Hacohen, Nir, Alyea, Edwin P., Kim, Haesook T., Wu, Catherine J.

“…Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that…”
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Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells by Burkhardt, Ute E, Hainz, Ursula, Stevenson, Kristen, Goldstein, Natalie R, Pasek, Mildred, Naito, Masayasu, Wu, Di, Ho, Vincent T, Alonso, Anselmo, Hammond, Naa Norkor, Wong, Jessica, Sievers, Quinlan L, Brusic, Ana, McDonough, Sean M, Zeng, Wanyong, Perrin, Ann, Brown, Jennifer R, Canning, Christine M, Koreth, John, Cutler, Corey, Armand, Philippe, Neuberg, Donna, Lee, Jeng-Shin, Antin, Joseph H, Mulligan, Richard C, Sasada, Tetsuro, Ritz, Jerome, Soiffer, Robert J, Dranoff, Glenn, Alyea, Edwin P, Wu, Catherine J

“…Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell…”
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Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells by Biernacki, Melinda A, Marina, Ovidiu, Zhang, Wandi, Liu, Fenglong, Bruns, Ingmar, Cai, Ann, Neuberg, Donna, Canning, Christine M, Alyea, Edwin P, Soiffer, Robert J, Brusic, Vladimir, Ritz, Jerome, Wu, Catherine J

“…Curative effects of graft-versus-leukemia-based therapies such as donor lymphocyte infusion (DLI) for chronic myelogenous leukemia (CML) may result from…”
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Graft-versus-Leukemia Antigen CML66 Elicits Coordinated B-Cell and T-Cell Immunity after Donor Lymphocyte Infusion by WANDI ZHANG, CHOI, Jaewon, RITZ, Jerome, SOIFFER, Robert J, WU, Catherine J, WANYONG ZENG, ROGERS, Shelby A, ALYEA, Edwin P, RHEINWALD, James G, CANNING, Christine M, BRUSIC, Vladimir, SASADA, Tetsuro, REINHERZ, Ellis L

“…The target antigens of graft-versus-leukemia that are tumor associated are incompletely characterized. We examined responses developing against CML66, an…”
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Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens by MARINA, Ovidiu, HAINZ, Ursula, ALYEA, Edwin P, CANNING, Christine M, SOIFFER, Robert J, RITZ, Jerome, WU, Catherine J, BIERNACKI, Melinda A, WANDI ZHANG, CAI, Ann, DUKE-COHAN, Jonathan S, FENGLONG LIU, BRUSIC, Vladimir, NEUBERG, Donna, KUTOK, Jeffery L

“…Patients with chronic lymphocytic leukemia (CLL) who relapse after allogeneic transplant may achieve durable remission following donor lymphocyte infusion…”
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Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans by Lin, Yun, Zhang, Li, Cai, Ann X, Lee, Mark, Zhang, Wandi, Neuberg, Donna, Canning, Christine M, Soiffer, Robert J, Alyea, Edwin P, Ritz, Jerome, Hacohen, Nir, Means, Terry K, Wu, Catherine J

“…Donor lymphocyte infusion (DLI), whereby donor mononuclear cells are infused into patients, is one of the few effective immunotherapeutic strategies that…”
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Reversal of T Cell Exhaustion in Pre-Treatment Marrow T Cells Is Associated with Effective Graft-Versus-Leukemia Responses to Donor Lymphocyte Infusion by Bachireddy, Pavan, Hainz, Ursula, Rooney, Michael, Pozdnyakova, Olga, Aldridge, Julie, Haining, W. Nicholas, Goldstein, Natalie R., Canning, Christine M, Soiffer, Robert J., Ritz, Jerome, Hacohen, Nir, Kim, Haesook T, Alyea, Edwin P, Wu, Catherine J

“…Abstract 1903 Donor lymphocyte infusion (DLI) can provide curative treatment for relapsed hematologic malignancies following allogeneic hematopoietic stem cell…”
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Autologous Whole Tumor Cell Vaccination Early After Allogeneic Stem Cell Transplantation Elicits Anti-Tumor T Cell Responses in Patients with Advanced Chronic Lymphocytic Leukemia (CLL) by Burkhardt, Ute E., Hainz, Ursula, Stevenson, Kristen E., Wu, Di, Ho, Vincent T., Goldstein, Natalie R., Pasek, Mildred, Brown, Jennifer R., Canning, Christine M, Koreth, John, Cutler, Corey, Armand, Philippe, Neuberg, Donna S., Antin, Joseph H., Sasada, Tetsuro, Ritz, Jerome, Dranoff, Glenn, Soiffer, Robert J., Alyea, Edwin P, Wu, Catherine J.

“…Abstract 1892▪▪This icon denotes a clinically relevant abstract Patients with advanced hematological malignancies remain at high risk for eventual disease…”
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Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies by ATKINS, M. B, ROBERTSON, M. J, MIER, J. W, CANNING, C. M, BATTIATO, L, TAHARA, H, SHERMAN, M. L, GORDON, M, LOTZE, M. T, DECOSTE, M, DUBOIS, J. S, RITZ, J, SANDLER, A. B, EDINGTON, H. D, GARZONE, P. D

“…A Phase I dose escalation trial of i.v. administered recombinant human interleukin 12 (rhIL-12) was performed to determine its toxicity, maximum tolerated dose…”
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Graft-versus-leukemia antigen CML66 elicits coordinated B and T cell immunity after donor lymphocyte infusion by Zhang, Wandi, Choi, Jaewon, Zeng, Wanyong, Rogers, Shelby A., Alyea, Edwin P., Rheinwald, James G., Canning, Christine M., Brusic, Vladimir, Sasada, Tetsuro, Reinherz, Ellis L., Ritz, Jerome, Soiffer, Robert J., Wu, Catherine J.

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Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include non-mutated B cell antigens by Marina, Ovidiu, Hainz, Ursula, Biernacki, Melinda A., Zhang, Wandi, Cai, Ann, Duke-Cohan, Jonathan S., Liu, Fenglong, Brusic, Vladimir, Neuberg, Donna, Kutok, Jeffery L., Alyea, Edwin P., Canning, Christine M., Soiffer, Robert J., Ritz, Jerome, Wu, Catherine J.

“…Patients with chronic lymphocytic leukemia (CLL) who relapse after allogeneic transplant may achieve durable remission following donor lymphocytes infusion…”
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Antigen targets of remission-inducing immune therapy are expressed on CML progenitor cells by Biernacki, Melinda A., Marina, Ovidiu, Zhang, Wandi, Liu, Fenglong, Bruns, Ingmar, Cai, Ann, Neuberg, Donna, Canning, Christine M., Alyea, Edwin P., Soiffer, Robert J., Brusic, Vladimir, Ritz, Jerome, Wu, Catherine J.

“…The curative effect of existing graft-versus-leukemia (GvL)-based therapies such as donor lymphocyte infusion (DLI) for chronic myeloid leukemia (CML) may…”
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Efificacious Immune Therapy in Chronic Myelogenous Leukemia (CML) Recognizes Antigens That Are Expressed on CML Progenitor Cells by BIERNACKI, Melinda A, MARINA, Ovidiu, BRUSIC, Vladimir, RITZ, Jerome, WU, Catherine J, WANDI ZHANG, FENGLONG LIU, BRUNS, Ingmar, CAI, Ann, NEUBERG, Donna, CANNING, Christine M, ALYEA, Edwin P, SOIFFER, Robert J

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Immunoproteomic Identification of Graft-Versus-Leukemia Targets in Patients with Chronic Lymphocytic Leukemia by Marina, Ovidiu, Biernacki, Melinda, Cai, Ann, Zhang, Wandi, Duke-Cohan, Jonathan S., Brusic, Vladimir, Liu, Fenglong, Alyea, Edwin, Canning, Christine M., Soiffer, Robert, Ritz, Jerome, Wu, Catherine J.

“…Chronic lymphocytic leukemia (CLL) is susceptible to immune-mediated destruction, as demonstrated by the potentially curative graft-versus-leukemia (GvL)…”
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Effective Graft-Versus-Leukemia Responses Are Associated with the Presence of Nucleic Acid-Immunoglobulin Complexes That Stimulate TLR8 and TLR9 by Lin, Yun, Means, Terry, Alyea, Edwin P., Canning, Christine M., Soiffer, Robert J., Ritz, Jerome, Wu, Catherine J.

“…To elucidate the basis of the potent graft versus leukemia (GvL) immune response that is initiated with donor lymphocyte infusion (DLI), we hypothesized the…”
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