Search Results - "Canning, Brendan J."

Reflex regulation of airway smooth muscle tone by Canning, Brendan J

“…Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland Autonomic nerves in most mammalian species mediate both contractions and relaxations of airway…”
Get full text

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling by Hollenhorst, Monika I., Jurastow, Innokentij, Nandigama, Rajender, Appenzeller, Silke, Li, Lei, Vogel, Jörg, Wiederhold, Stephanie, Althaus, Mike, Empting, Martin, Altmüller, Janine, Hirsch, Anna K. H., Flockerzi, Veit, Canning, Brendan J., Saliba, Antoine‐Emmanuel, Krasteva‐Christ, Gabriela

“…For protection from inhaled pathogens many strategies have evolved in the airways such as mucociliary clearance and cough. We have previously shown that…”
Get full text

Cholinergic chemosensory cells in the trachea regulate breathing by Krasteva, Gabriela, Canning, Brendan J., Hartmann, Petra, Veres, Tibor Z., Papadakis, Tamara, Mühlfeld, Christian, Schliecker, Kirstin, Tallini, Yvonne N., Braun, Armin, Hackstein, Holger, Baal, Nelli, Weihe, Eberhard, Schütz, Burkhard, Kotlikoff, Michael, Ibanez-Tallon, Ines, Kummer, Wolfgang

“…In the epithelium of the lower airways, a cell type of unknown function has been termed "brush cell" because of a distinctive ultrastructural feature, an…”
Get full text

Encoding of the cough reflex in anesthetized guinea pigs by Canning, Brendan J, Mori, Nanako

“…We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally…”
Get more information

Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways by Yu, Li, Liu, Qi, Canning, Brendan J.

“…Mast cells play an essential role in immediate type hypersensitivity reactions and in chronic allergic diseases of the airways, including asthma. Mast cell…”
Get full text

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies by West, Peter W, Canning, Brendan J, Merlo-Pich, Emilio, Woodcock, Ashley A, Smith, Jaclyn A

“…Neuroplasticity of bronchopulmonary afferent neurons that respond to mechanical and chemical stimuli may sensitize the cough reflex. Afferent drive in cough is…”
Get full text

Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease by Canning, Brendan J., PhD

“…Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough…”
Get full text

Central regulation of the cough reflex: Therapeutic implications by Canning, Brendan J

“…Abstract In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been…”
Get full text

Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves by Kocmalova, Michaela, Kollarik, Marian, Canning, Brendan J, Ru, Fei, Adam Herbstsomer, R, Meeker, Sonya, Fonquerna, Silvia, Aparici, Monica, Miralpeix, Montserrat, Chi, Xian Xuan, Li, Baolin, Wilenkin, Ben, McDermott, Jeff, Nisenbaum, Eric, Krajewski, Jeffrey L, Undem, Bradley J

“…Little is known about the neuronal voltage-gated sodium channels (NaVs) that control neurotransmission in the parasympathetic nervous system. We evaluated the…”
Get more information

Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans by Dicpinigaitis, Peter V, Canning, Brendan J, Garner, Rachel, Paterson, Blake

“…Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack…”
Get more information

Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways by Zaccone, Eric J, Lieu, TinaMarie, Muroi, Yukiko, Potenzieri, Carl, Undem, Blair E, Gao, Peisong, Han, Liang, Canning, Brendan J, Undem, Bradley J

“…The effect of respiratory tract viral infection on evoked cough in guinea pigs was evaluated. Guinea pigs were inoculated intranasally with either…”
Get full text

Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs by Mazzone, Stuart B., Mori, Nanako, Canning, Brendan J.

“…Cough initiated from the trachea and larynx in anaesthetized guinea-pigs is mediated by capsaicin-insensitive, mechanically sensitive vagal afferent neurones…”
Get full text

Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons by Muroi, Yukiko, Ru, Fei, Kollarik, Marian, Canning, Brendan J., Hughes, Stephen A., Walsh, Stacey, Sigg, Martin, Carr, Michael J., Undem, Bradley J.

“…Non‐technical summary  Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes…”
Get full text

Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia by Muroi, Yukiko, Ru, Fei, Chou, Yang-Ling, Carr, Michael J, Undem, Bradley J, Canning, Brendan J

“…Adeno-associated virus delivery systems and short hairpin RNA (shRNA) were used to selectively silence the voltage-gated sodium channel NaV 1.7 in the nodose…”
Get more information

Selective Expression of a Sodium Pump Isozyme by Cough Receptors and Evidence for Its Essential Role in Regulating Cough by Mazzone, Stuart B, Reynolds, Sandra M, Mori, Nanako, Kollarik, Marian, Farmer, David G, Myers, Allen C, Canning, Brendan J

“…We have identified a distinct subtype of airway vagal afferent nerve that plays an essential role in regulating the cough reflex. These afferents are…”
Get full text

Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs by Canning, Brendan J., Mazzone, Stuart B., Meeker, Sonya N., Mori, Nanako, Reynolds, Sandra M., Undem, Bradley J.

“…We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guinea-pigs. Cough was evoked by electrical or mechanical…”
Get full text

Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs by Chou, Yang-Ling, Scarupa, Mark D, Mori, Nanako, Canning, Brendan J

“…The hypothesis that respiratory reflexes, such as cough, reflect the net and often opposing effects of activation of multiple afferent nerve subpopulations…”
Get more information

Inhibition of FcϵRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement by Yokoi, Hidenori, MD, Choi, Oksoon H., PhD, Hubbard, Walter, PhD, Lee, Hyun-Sil, PhD, Canning, Brendan J., PhD, Lee, Hyun H., MD, Ryu, Seung-Duk, PhD, von Gunten, Stephan, MD, PhD, Bickel, Carol A., MS, Hudson, Sherry A., MSB, MacGlashan, Donald W., MD, PhD, Bochner, Bruce S., MD

“…Background Sialic acid–binding immunoglobulin-like lectins (Siglecs) are a family of glycan-binding inhibitory receptors, and among them, Siglec-8 is…”
Get full text

Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs by Canning, Brendan J, Farmer, David G, Mori, Nanako

“…Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1…”
Get more information

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough by Badri, Huda, Gibbard, Carmen, Denton, Dimitra, Satia, Imran, Al-Sheklly, Bashar, Dockry, Rachel J, Holt, Kimberley, McGuiness, Kevin, Treadway, Sam, Whorwell, Peter, Houghton, Lesley, Lee, Augustine, Escott, K Jane, Lee, Theresa, Wilkinson, Greame, Holt, Alison, Canning, Brendan J, Smith, Jacky A

“…Baclofen is a centrally acting γ-aminobutyric acid type B (GABA ) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex;…”
Get full text