Search Results - "Canning, Brendan"

Reflex regulation of airway smooth muscle tone by Canning, Brendan J

“…Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland Autonomic nerves in most mammalian species mediate both contractions and relaxations of airway…”
Get full text

Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report by Canning, Brendan J, Chang, Anne B, Bolser, Donald C, Smith, Jaclyn A, Mazzone, Stuart B, McGarvey, Lorcan

“…Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These…”
Get full text

Is There (Will There Be) a Post-COVID-19 Chronic Cough? by Dicpinigaitis, Peter V., Canning, Brendan J.

Get full text

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling by Hollenhorst, Monika I., Jurastow, Innokentij, Nandigama, Rajender, Appenzeller, Silke, Li, Lei, Vogel, Jörg, Wiederhold, Stephanie, Althaus, Mike, Empting, Martin, Altmüller, Janine, Hirsch, Anna K. H., Flockerzi, Veit, Canning, Brendan J., Saliba, Antoine‐Emmanuel, Krasteva‐Christ, Gabriela

“…For protection from inhaled pathogens many strategies have evolved in the airways such as mucociliary clearance and cough. We have previously shown that…”
Get full text

Cough hypersensitivity and chronic cough by Chung, Kian Fan, McGarvey, Lorcan, Song, Woo-Jung, Chang, Anne B., Lai, Kefang, Canning, Brendan J., Birring, Surinder S., Smith, Jaclyn A., Mazzone, Stuart B.

“…Chronic cough is globally prevalent across all age groups. This disorder is challenging to treat because many pulmonary and extrapulmonary conditions can…”
Get full text

essential component to brainstem cough gating identified in anesthetized guinea pigs by Canning, Brendan J, Mori, Nanako

“…Coughing protects and clears the airways and lungs of inhaled irritants, particulates, pathogens, and accumulated secretions. An initial urge to cough, and an…”
Get full text

Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs by Chou, Yang-Ling, Mori, Nanako, Canning, Brendan J

“…We have addressed the hypothesis that the opposing effects of bronchopulmonary C-fiber activation on cough are attributable to the activation of C-fiber…”
Get more information

Cholinergic chemosensory cells in the trachea regulate breathing by Krasteva, Gabriela, Canning, Brendan J., Hartmann, Petra, Veres, Tibor Z., Papadakis, Tamara, Mühlfeld, Christian, Schliecker, Kirstin, Tallini, Yvonne N., Braun, Armin, Hackstein, Holger, Baal, Nelli, Weihe, Eberhard, Schütz, Burkhard, Kotlikoff, Michael, Ibanez-Tallon, Ines, Kummer, Wolfgang

“…In the epithelium of the lower airways, a cell type of unknown function has been termed "brush cell" because of a distinctive ultrastructural feature, an…”
Get full text

Evidence for Alpha7 Nicotinic Receptor Activation During the Cough Suppressing Effects Induced by Nicotine and Identification of ATA-101 as a Potential Novel Therapy for the Treatment of Chronic Cough by Canning, Brendan J, Liu, Qi, Tao, Mayuko, DeVita, Robert, Perelman, Michael, Hay, Douglas W, Dicpinigaitis, Peter V, Liang, Jing

“…Studies performed in healthy smokers have documented a diminished responsiveness to tussive challenges, and several lines of experimental evidence implicate…”
Get full text

Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease by Canning, Brendan J., PhD

“…Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough…”
Get full text

Encoding of the cough reflex in anesthetized guinea pigs by Canning, Brendan J, Mori, Nanako

“…We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally…”
Get more information

Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness by Han, Liang, Limjunyawong, Nathachit, Ru, Fei, Li, Zhe, Hall, Olivia J., Steele, Haley, Zhu, Yuyan, Wilson, Julie, Mitzner, Wayne, Kollarik, Marian, Undem, Bradley J., Canning, Brendan J., Dong, Xinzhong

“…Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that…”
Get full text

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response by MORICE, Alyn H, JAKES, Adam D, PAVORD, Ian D, VAN DEN BERG, Jan, SONG, Woo-Jung, MILLQVIST, Eva, FARRELL, Michael J, MAZZONE, Stuart B, DICPINIGAITIS, Peter, FARUQI, Shoaib, BIRRING, Surinder S, MCGARVEY, Lorcan, CANNING, Brendan, SMITH, Jaclyn A, PARKER, Sean M, KIAN FAN CHUNG, KEFANG LAI

“…Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have…”
Get full text

P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough by Dicpinigaitis, Peter V., McGarvey, Lorcan P., Canning, Brendan J.

“…Cough is among the most common complaints for which patients worldwide seek medical attention. In a majority of patients with chronic cough (defined as cough…”
Get full text

Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways by Zaccone, Eric J, Lieu, TinaMarie, Muroi, Yukiko, Potenzieri, Carl, Undem, Blair E, Gao, Peisong, Han, Liang, Canning, Brendan J, Undem, Bradley J

“…The effect of respiratory tract viral infection on evoked cough in guinea pigs was evaluated. Guinea pigs were inoculated intranasally with either…”
Get full text

Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways by Yu, Li, Liu, Qi, Canning, Brendan J.

“…Mast cells play an essential role in immediate type hypersensitivity reactions and in chronic allergic diseases of the airways, including asthma. Mast cell…”
Get full text

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies by West, Peter W, Canning, Brendan J, Merlo-Pich, Emilio, Woodcock, Ashley A, Smith, Jaclyn A

“…Neuroplasticity of bronchopulmonary afferent neurons that respond to mechanical and chemical stimuli may sensitize the cough reflex. Afferent drive in cough is…”
Get full text

Acute activation of bronchopulmonary vagal nociceptors by type I interferons by Patil, Mayur J., Ru, Fei, Sun, Hui, Wang, Jingya, Kolbeck, Roland R., Dong, Xinzhong, Kollarik, Marian, Canning, Brendan J., Undem, Bradley J.

“…Key points Type I interferon receptors are expressed by the majority of vagal C‐fibre neurons innervating the respiratory tract Interferon alpha and beta…”
Get full text

Central regulation of the cough reflex: Therapeutic implications by Canning, Brendan J

“…Abstract In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been…”
Get full text

Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelines by Canning, Brendan J

“…To describe the anatomy and neurophysiology of the cough reflex. A review of the literature was carried out using PubMed and the ISI Web of Knowledge from 1951…”
Get more information