Search Results - "Canniff, Paul C."

Tremelimumab (CP‐675,206), a Cytotoxic T Lymphocyte–Associated Antigen 4 Blocking Monoclonal Antibody in Clinical Development for Patients with Cancer by Ribas, Antoni, Hanson, Douglas C., Noe, Dennis A., Millham, Robert, Guyot, Deborah J., Bernstein, Steven H., Canniff, Paul C., Sharma, Amarnath, Gomez‐Navarro, Jesus

“…Learning Objectives After completing the course, the reader will be able to: Educate community oncologists about the promise of anti‐CTLA‐4 monoclonal…”
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UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation by Hanson, Douglas C, Nguyen, Angela, Mather, Robert J, Rauer, Heiko, Koch, Kevin, Burgess, Laurence E, Rizzi, James P, Donovan, Carol B, Bruns, Matthew J, Canniff, Paul C, Cunningham, Ann C, Verdries, Kimberly A, Mena, Edward, Kath, John C, Gutman, George A, Cahalan, Michael D, Grissmer, Stephan, Chandy, K George

“…UK‐78,282, a novel piperidine blocker of the T lymphocyte voltage‐gated K+ channel, Kv1.3, was discovered by screening a large compound file using a…”
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Phosphodiesterase isozyme inhibition, activation of the cAMP system, and positive inotropy mediated by milrinone in isolated guinea pig cardiac muscle by Silver, P J, Harris, A L, Canniff, P C, Lepore, R E, Bentley, R G, Hamel, L T, Evans, D B

“…The purpose of the present study was to examine the interrelationships among phosphodiesterase (PDE) isozyme inhibition, cAMP formation, activation of…”
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Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Carabateas, Philip M, Rumney, Squire, Pilling, Garry M, Krafte, Douglas S, Volberg, Walter A, Dillon, Kathleen, Dugrenier, Nancy, Briggs, G. Maurice, Canniff, Paul C, Gorczyca, William P, Stankus, Gerald P, Ezrin, Alan M

“…Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in…”
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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation by Nguyen, A, Kath, J C, Hanson, D C, Biggers, M S, Canniff, P C, Donovan, C B, Mather, R J, Bruns, M J, Rauer, H, Aiyar, J, Lepple-Wienhues, A, Gutman, G A, Grissmer, S, Cahalan, M D, Chandy, K G

“…The nonpeptide agent CP-339,818 (1-benzyl-4-pentylimino-1,4-dihydroquinoline) and two analogs (CP-393,223 and CP-394,322) that differ only with respect to the…”
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