Search Results - "Cann, Reginald O"

Process Development for a Large Scale Stereoselective Synthesis of (Z)-(1-Bromobut-1-ene-1,2-diyl)dibenzene, a Key Intermediate of a Selective Estrogen Receptor Modulator by Cann, Reginald O, Waltermire, Robert E, Chung, Jihchin, Oberholzer, Matthew, Kasparec, Jiri, Ye, Yun K, Wethman, Robert

“…Two efficient large scale syntheses of (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene are described. The first is a three-step synthetic sequence from…”
Get full text

Selection of an Enantioselective Process for the Preparation of a CGRP Receptor Inhibitor by Cann, Reginald O, Chen, Chung-Pin H, Gao, Qi, Hanson, Ronald L, Hsieh, Daniel, Li, Jun, Lin, Dong, Parsons, Rodney L, Pendri, Yadagiri, Nielsen, R. Brent, Nugent, William A, Parker, William L, Quinlan, Sandra, Reising, Nathan P, Remy, Brenda, Sausker, Justin, Wang, Xuebao

“…(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazine-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide…”
Get full text

Enynones in Organic Synthesis. 7. Substituent Effects on the .alpha.-Tocopherol-Catalyzed Cyclization of Enynones to Methylenecyclopentenones. Convenient Syntheses of Members of the Methylenomycin Class of Antibiotics by Jacobi, Peter A, Brielmann, Harry L, Cann, Reginald O

Get full text

Zwitterionic Sulfobetaine Inhibitors of Squalene Synthase by Spencer, Thomas A, Onofrey, Thomas J, Cann, Reginald O, Russel, Jonathon S, Lee, Laura E, Blanchard, Daniel E, Castro, Alfredo, Gu, Peide, Jiang, Guojian, Shechter, Ishaiahu

“…A substantial number of sulfobetaines (e.g., 10) have been synthesized and evaluated as inhibitors of squalene synthase (SS) on the basis of the idea that…”
Get full text

Enynones in Organic Synthesis. 6. Synthesis of Spirocyclic Methylenecyclopentenones and Analogs of the Methylenomycin Class of Antibiotics. Mechanism of Phenol Catalysis by Jacobi, Peter A, Armacost, Lisa M, Brielmann, Harry L, Cann, Reginald O, Kravitz, Joseph I, Martinelli, Michael J

Get full text

Synthesis of unsymmetric cyclic urea diols, a novel class of HIV protease inhibitors by Stone, Benjamin R.P., Harris, Gregory D., Cann, Reginald O., Smyser, Thomas E., Confalone, Pat N.

“…Unsymmetric cyclic urea diols of general structure 1 can be prepared either via an isourea derived from the symmetric diamine 2 or by the selective removal of…”
Get full text

Sulfobetaine zwitterionic inhibitors of squalene synthase by Shechter, Ishaiahu, Gu, Peide, Jiang, Guojian, Onofrey, Thomas J., Cann, Reginald O., Castro, Alfredo, Spencer, Thomas A.

“…Zwitterions such as farnesyl sulfobetaine 8 are a new type of inhibitor of squalene synthase that, while maintaining overall neutrality, mimic both the…”
Get full text