Search Results - "Canman, C. E"

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation by Baskaran, R, Wood, L. D, Whitaker, L. L, Canman, C. E, Morgan, S. E, Xu, Y, Barlow, C, Baltimore, D, Wynshaw-Boris, A, Kastan, M. B, Wang, J. Y. J

“…Ataxia telangiectasia (AT) is a rare human autosomal recessive disorder with pleiotropic phenotypes, including neuronal degeneration, immune dysfunction,…”
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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53 by Canman, Christine E., Lim, Dae-Sik, Cimprich, Karlene A., Taya, Yoichi, Tamai, Katsuyuki, Sakaguchi, Kazuyasu, Appella, Ettore, Kastan, Michael B., Siliciano, Janet D.

“…The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia…”
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Growth factor modulation of p53-mediated growth arrest versus apoptosis by Canman, C E, Gilmer, T M, Coutts, S B, Kastan, M B

“…Irradiation of mammalian cells can cause cell cycle perturbations and apoptotic cell death. We have investigated the modulation of these physiologic end points…”
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Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor by Inaba, Toshiya, Inukai, Takeshi, Yoshihara, Takao, Seyschab, Helga, Ashmun, Richard A, Canman, Christine E, Laken, Steven J, Kastan, Michael B, Look, A. Thomas

“…The E2A-HLF (for hepatic leukaemia factor) fusion gene, formed by action of the t(17;19) (q22;p13) chromosomal translocation, drives the leukaemic…”
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Loss of atm radiosensitizes multiple p53 null tissues by WESTPHAL, C. H, HOYES, K. P, CANMAN, C. E, XIN HUANG, KASTAN, M. B, HENDRY, J. H, LEDER, P

“…An unusual clinical finding in ataxia-telangiectasia, a human disorder caused by mutations in atm, is exquisite sensitivity to gamma irradiation. By contrast,…”
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells by METCALFE, S. M, CANMAN, C. E, MILNER, J, MORRIS, R. E, GOLDMAN, S, KASTAN, M. B

“…Certain growth regulatory kinases contain a common domain related to the phospho-inositol 3 (PI-3) kinase catalytic site. These include the ATM gene product,…”
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Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members by Kim, S T, Lim, D S, Canman, C E, Kastan, M B

“…Ataxia telangiectasia mutated (ATM) phosphorylates p53 protein in response to ionizing radiation, but the complex phenotype of AT cells suggests that it must…”
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Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation by AHN, Joon-Young, SCHWARZ, Julie K, PIWNICA-WORMS, Helen, CANMAN, Christine E

“…Eukaryotic cells activate an evolutionarily conserved set of proteins that rapidly induce cell cycle arrest to prevent replication or segregation of damaged…”
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis by EL-DEIRY, W. S, HARPER, J. W, WIMAN, K. G, MERCER, W. E, KASTAN, M. B, KOHN, K. W, ELLEDGE, S. J, KINZLER, K. W, VOGELSTEIN, B, O'CONNOR, P. M, VELCULESCU, V. E, CANMAN, C. E, JACKMAN, J, PIETENPOL, J. A, BURRELL, M, HILL, D. E, WANG, Y

“…The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinases. In the present studies,…”
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DNA damage induces phosphorylation of the amino terminus of p53 by Siliciano, J D, Canman, C E, Taya, Y, Sakaguchi, K, Appella, E, Kastan, M B

“…Data are presented demonstrating that DNA damage leads to specific post-translational modifications of p53 protein. Using two-dimensional peptide mapping of in…”
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Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis by CANMAN, C. E, KASTAN, M. B

“…Deregulation of the S-phase promoting E2F-1 transcription factor has been shown to cooperate with p53 to induce apoptosis. BaF3 cells undergo rapid,…”
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Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase by CANMAN, C. E, RADANY, E. H, PARSELS, L. A, DAVIS, M. A, LAWRENCE, T. S, MAYBAUM, J

“…Recent studies from our laboratory suggested that, in some human colorectal tumor cell lines, sensitivity to fluorodeoxyuridine may depend upon the extent of…”
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Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate by CANMAN, C. E, LAWRENCE, T. S, SHEWACH, D. S, HSIN-YI TANG, MAYBAUM, J

“…Deoxyuridine triphosphate (dUTP) misincorporation and uracil misrepair have long been implicated in fluoropyrimidine-induced DNA damage; however, the enzymatic…”
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Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity by Canman, C E, Tang, H Y, Normolle, D P, Lawrence, T S, Maybaum, J

“…We have previously shown that treatment of the HT29 human colorectal tumor (HCT) cell line with 100 nM 5-fluorodeoxyuridine (FdUrd) induces DNA fragments…”
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Signal transduction. Three paths to stress relief by Canman, C E, Kastan, M B

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Replication checkpoint: Preventing mitotic catastrophe by Canman, Christine E

“…A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is…”
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DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis by Canman, C E, Chen, C Y, Lee, M H, Kastan, M B

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P53, cell cycle control and apoptosis: implications for cancer by Kastan, M B, Canman, C E, Leonard, C J

“…Cellular proliferation depends on the rates of both cell division and cell death. Tumors frequently have decreased cell death as a primary mode of increased…”
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The role of ATM in DNA damage responses and cancer by Canman, C E, Lim, D S

“…Ataxia-telangiectasia (AT) is a complex, autosomal recessive disorder characterized by cerebellar ataxia, believed to result from progressive…”
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ATM Binds to β -adaptin in Cytoplasmic Vesicles by Lim, Dae-Sik, Kirsch, David G., Canman, Christine E., Ahn, Jin-Hyun, Ziv, Yael, Newman, Lori S., Darnell, Robert B., Shiloh, Yosef, Kastan, Michael B.

“…Inherited mutations in the ATM gene lead to a complex clinical phenotype characterized by neuronal degeneration, oculocutaneous telangiectasias, immune…”
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