Search Results - "Canman, C"

A bidirectional relationship between sleep and oxidative stress in Drosophila by Hill, Vanessa M, O'Connor, Reed M, Sissoko, Gunter B, Irobunda, Ifeoma S, Leong, Stephen, Canman, Julie C, Stavropoulos, Nicholas, Shirasu-Hiza, Mimi

“…Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a…”
Get full text

Circadian autophagy drives iTRF-mediated longevity by Ulgherait, Matt, Midoun, Adil M., Park, Scarlet J., Gatto, Jared A., Tener, Samantha J., Siewert, Julia, Klickstein, Naomi, Canman, Julie C., Ja, William W., Shirasu-Hiza, Mimi

“…Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing treatment for organisms from  Drosophila  to humans 1 – 5 . TRF restricts…”
Get full text

Chromosome segregation occurs by microtubule pushing in oocytes by Laband, Kimberley, Le Borgne, Rémi, Edwards, Frances, Stefanutti, Marine, Canman, Julie C., Verbavatz, Jean-Marc, Dumont, Julien

“…During cell division, spindle microtubules ensure an equal repartition of chromosomes between the two daughter cells. While the kinetochore-dependent…”
Get full text

Circadian regulation of mitochondrial uncoupling and lifespan by Ulgherait, Matt, Chen, Anna, McAllister, Sophie F., Kim, Han X., Delventhal, Rebecca, Wayne, Charlotte R., Garcia, Christian J., Recinos, Yocelyn, Oliva, Miles, Canman, Julie C., Picard, Martin, Owusu-Ansah, Edward, Shirasu-Hiza, Mimi

“…Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show…”
Get full text

Maternal inheritance of functional centrioles in two parthenogenetic nematodes by Perrier, Aurélien, Guiglielmoni, Nadège, Naquin, Delphine, Gorrichon, Kevin, Thermes, Claude, Lameiras, Sonia, Dammermann, Alexander, Schiffer, Philipp H., Brunstein, Maia, Canman, Julie C., Dumont, Julien

“…Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in…”
Get full text

Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes by Pitayu-Nugroho, Laras, Aubry, Mélanie, Laband, Kimberley, Geoffroy, Hélène, Ganeswaran, Thadshagine, Primadhanty, Audi, Canman, Julie C., Dumont, Julien

“…During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend…”
Get full text

Rho GTPases in animal cell cytokinesis: An occupation by the one percent by Jordan, Shawn N., Canman, Julie C.

“…Rho GTPases are molecular switches that elicit distinct effects on the actomyosin cytoskeleton to accurately promote cytokinesis. Although they represent less…”
Get full text

Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication by Wang, Jia, Batourina, Ekatherina, Schneider, Kerry, Souza, Spenser, Swayne, Theresa, Liu, Chang, George, Christopher D., Tate, Tiffany, Dan, Hanbin, Wiessner, Gregory, Zhuravlev, Yelena, Canman, Julie C., Mysorekar, Indira U., Mendelsohn, Cathy Lee

“…The urothelium is an epithelia barrier lined by a luminal layer of binucleated, octoploid, superficial cells. Superficial cells are critical for production and…”
Get full text

Inhibition of Rac by the GAP Activity of Centralspindlin Is Essential for Cytokinesis by Canman, Julie C, Lewellyn, Lindsay, Laband, Kimberley, Smerdon, Stephen J, Desai, Arshad, Bowerman, Bruce, Oegema, Karen

“…During cytokinesis, the guanosine triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction. RhoA signaling is controlled by the…”
Get full text

FLIRT: fast local infrared thermogenetics for subcellular control of protein function by Hirsch, Sophia M., Sundaramoorthy, Sriramkumar, Davies, Tim, Zhuravlev, Yelena, Waters, Jennifer C., Shirasu-Hiza, Mimi, Dumont, Julien, Canman, Julie C.

“…FLIRT (fast local infrared thermogenetics) is a microscopy-based technology to locally and reversibly manipulate protein function while simultaneously…”
Get full text

Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption by Delventhal, Rebecca, O'Connor, Reed M, Pantalia, Meghan M, Ulgherait, Matthew, Kim, Han X, Basturk, Maylis K, Canman, Julie C, Shirasu-Hiza, Mimi

“…In , ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these neurons secrete the neuropeptide Pdf and have been called…”
Get full text

Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior by Pantalia, Meghan, Lin, Zhi, Tener, Samantha J., Qiao, Bing, Tang, Grace, Ulgherait, Matthew, O’Connor, Reed, Delventhal, Rebecca, Volpi, Julia, Syed, Sheyum, Itzhak, Nissim, Canman, Julie C., Fernández, María Paz, Shirasu-Hiza, Mimi

“…Inhibitors of enzymes that inactivate amine neurotransmitters (dopamine, serotonin), such as catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO),…”
Get full text

Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly by Macaisne, Nicolas, Bellutti, Laura, Laband, Kimberley, Edwards, Frances, Pitayu-Nugroho, Laras, Gervais, Alison, Ganeswaran, Thadshagine, Geoffroy, Hélène, Maton, Gilliane, Canman, Julie C, Lacroix, Benjamin, Dumont, Julien

“…During cell division, chromosome segregation is orchestrated by a microtubule-based spindle. Interaction between spindle microtubules and kinetochores is…”
Get full text

Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder by Tener, Samantha J., Lin, Zhi, Park, Scarlet J., Oraedu, Kairaluchi, Ulgherait, Matthew, Van Beek, Emily, Martínez-Muñiz, Andrés, Pantalia, Meghan, Gatto, Jared A., Volpi, Julia, Stavropoulos, Nicholas, Ja, William W., Canman, Julie C., Shirasu-Hiza, Mimi

“…Mutations in Cullin-3 ( Cul3 ), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we…”
Get full text

Kinetochore components are required for central spindle assembly by Maton, Gilliane, Edwards, Frances, Lacroix, Benjamin, Stefanutti, Marine, Laband, Kimberley, Lieury, Tiffany, Kim, Taekyung, Espeut, Julien, Canman, Julie C., Dumont, Julien

“…Using C. elegans zygotes, Dumont and colleagues find that kinetochore proteins, including KNL-1, participate in assembly of central spindle microtubules for…”
Get full text

High-Resolution Temporal Analysis Reveals a Functional Timeline for the Molecular Regulation of Cytokinesis by Davies, Tim, Jordan, Shawn N., Chand, Vandana, Sees, Jennifer A., Laband, Kimberley, Carvalho, Ana X., Shirasu-Hiza, Mimi, Kovar, David R., Dumont, Julien, Canman, Julie C.

“…To take full advantage of fast-acting temperature-sensitive mutations, thermal control must be extremely rapid. We developed the Therminator, a device capable…”
Get full text

The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint by De Antoni, Anna, Pearson, Chad G., Cimini, Daniela, Canman, Julie C., Sala, Valeria, Nezi, Luigi, Mapelli, Marina, Sironi, Lucia, Faretta, Mario, Salmon, Edward D., Musacchio, Andrea

“…Background: The spindle assembly checkpoint (SAC) imparts fidelity to chromosome segregation by delaying anaphase until all sister chromatid pairs have become…”
Get full text

BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore by Edwards, Frances, Maton, Gilliane, Gareil, Nelly, Canman, Julie C, Dumont, Julien

“…Accurate chromosome segregation relies on bioriented amphitelic attachments of chromosomes to microtubules of the mitotic spindle, in which sister chromatids…”
Get full text

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms by Cimini, Daniela, Moree, Ben, Canman, Julie C, Salmon, E D

“…Merotelic kinetochore orientation is an error that occurs when a single kinetochore becomes attached to microtubules from two spindle poles rather than just to…”
Get full text

Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity by Davies, Tim, Kim, Han X, Romano Spica, Natalia, Lesea-Pringle, Benjamin J, Dumont, Julien, Shirasu-Hiza, Mimi, Canman, Julie C

“…Cytokinesis, the physical division of one cell into two, is powered by constriction of an actomyosin contractile ring. It has long been assumed that all animal…”
Get full text