Search Results - "Cangelosi, Andrew L."

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion by Helman, Aharon, Cangelosi, Andrew L., Davis, Jeffrey C., Pham, Quan, Rothman, Arielle, Faust, Aubrey L., Straubhaar, Juerg R., Sabatini, David M., Melton, Douglas A.

“…A drastic transition at birth, from constant maternal nutrient supply in utero to intermittent postnatal feeding, requires changes in the metabolic system of…”
Get full text

Dihydroxyacetone phosphate signals glucose availability to mTORC1 by Orozco, Jose M., Krawczyk, Patrycja A., Scaria, Sonia M., Cangelosi, Andrew L., Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M.

“…The mechanistic target of rapamycin complex 1 (mTORC1) kinase regulates cell growth by setting the balance between anabolic and catabolic processes. To be…”
Get full text

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo by Bayraktar, Erol C., Baudrier, Lou, Özerdem, Ceren, Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Cangelosi, Andrew L., Sabatini, David M., Birsoy, Kıvanç, Chen, Walter W.

“…Mitochondria are metabolic organelles that are essential for mammalian life, but the dynamics of mitochondrial metabolism within mammalian tissues in vivo…”
Get full text

Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation by Li, Minghui, Kales, Stephen C, Ma, Ke, Shoemaker, Benjamin A, Crespo-Barreto, Juan, Cangelosi, Andrew L, Lipkowitz, Stanley, Panchenko, Anna R

“…Oncogenic mutations in the monomeric Casitas B-lineage lymphoma (Cbl) gene have been found in many tumors, but their significance remains largely unknown…”
Get full text

Fumarate is a terminal electron acceptor in the mammalian electron transport chain by Spinelli, Jessica B, Rosen, Paul C, Sprenger, Hans-Georg, Puszynska, Anna M, Mann, Jessica L, Roessler, Julian M, Cangelosi, Andrew L, Henne, Antonia, Condon, Kendall J, Zhang, Tong, Kunchok, Tenzin, Lewis, Caroline A, Chandel, Navdeep S, Sabatini, David M

“…For electrons to continuously enter and flow through the mitochondrial electron transport chain (ETC), they must ultimately land on a terminal electron…”
Get full text

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes by Laqtom, Nouf N., Dong, Wentao, Medoh, Uche N., Cangelosi, Andrew L., Dharamdasani, Vimisha, Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Heinze, Ivonne, Tang, Rachel, Grimm, Christian, Dang Do, An N., Porter, Forbes D., Ori, Alessandro, Sabatini, David M., Abu-Remaileh, Monther

“…Lysosomes have many roles, including degrading macromolecules and signalling to the nucleus 1 . Lysosomal dysfunction occurs in various human conditions, such…”
Get full text

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine by Cangelosi, Andrew L, Puszynska, Anna M, Roberts, Justin M, Armani, Andrea, Nguyen, Thao P, Spinelli, Jessica B, Kunchok, Tenzin, Wang, Brianna, Chan, Sze Ham, Lewis, Caroline A, Comb, William C, Bell, George W, Helman, Aharon, Sabatini, David M

“…The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in response to nutrients, including the amino acid leucine. In cultured cells,…”
Get full text

High fat diet and stem cells: Linking diet to intestinal tumor formation by Cangelosi, Andrew L., Yilmaz, Ömer H.

Get full text