Search Results - "Canfield, Melissa"

CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells by Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L

“…Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of…”
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Identification of novel azaindazole CCR1 antagonist clinical candidates by Harcken, Christian, Kuzmich, Daniel, Cook, Brain, Mao, Can, Disalvo, Darren, Razavi, Hossein, Swinamer, Alan, Liu, Pingrong, Zhang, Qiang, Kukulka, Alison, Skow, Donna, Patel, Mita, Patel, Monica, Fletcher, Kimberly, Sherry, Tara, Joseph, David, Smith, Dustin, Canfield, Melissa, Souza, Donald, Bogdanffy, Matthew, Berg, Karen, Brown, Maryanne

“…[Display omitted] •Scaffold hopping approach led to identification of novel indazole CCR1 antagonists.•Multi parameter optimization led to three clinical…”
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BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells by Lamb, David J, Wollin, Stefan Lutz, Schnapp, Andreas, Bischoff, Daniel, Erb, Klaus J, Bouyssou, Thierry, Guilliard, Bernd, Strasser, Christine, Wex, Eva, Blum, Sylvia, Thaler, Eva, Nickel, Helga, Radmacher, Oliver, Haas, Hannah, Swantek, Jennifer L, Souza, Don, Canfield, Melissa, White, Della, Panzenbeck, Mark, Kashem, Mohammed A, Sanville-Ross, Mary, Kono, Takeshi, Sewald, Katherina, Braun, Armin, Obernolte, Helena, Danov, Olga, Schaenzle, Gerhard, Rast, Georg, Maier, Gerd-Michael, Hoffmann, Matthias

“…BI 1002494 [(R)-4-{(R)-1-[7-(3,4,5-trimethoxy-phenyl)-[1,6]napthyridin-5-yloxy]-ethyl}pyrrolidin-2-one] is a novel, potent, and selective spleen tyrosine…”
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