Search Results - "Canessa, Cecilia M."

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels by Wu, Yangyu, Chen, Zhuyuan, Canessa, Cecilia M

“…ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated…”
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Structure and analysis of nanobody binding to the human ASIC1a ion channel by Wu, Yangyu, Chen, Zhuyuan, Sigworth, Fred J, Canessa, Cecilia M

“…ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and…”
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Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1 by Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.

“…The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this…”
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Impact of Recovery from Desensitization on Acid-sensing Ion Channel-1a (ASIC1a) Current and Response to High Frequency Stimulation by Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.

“…ASIC1a is a neuronal sodium channel activated by external H+ ions. To date, all the characterization of ASIC1a has been conducted applying long H+ stimuli…”
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Interaction of the Aromatics Tyr-72/Trp-288 in the Interface of the Extracellular and Transmembrane Domains Is Essential for Proton Gating of Acid-sensing Ion Channels by Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.

“…Acid-sensing ion channels are proton-activated ion channels expressed in the nervous system. They belong to the family of ENaC/Degenerins whose members share a…”
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An Amphipathic Helix Targets Serum and Glucocorticoid-Induced Kinase 1 to the Endoplasmic Reticulum-Associated Ubiquitin-Conjugation Machinery by Arteaga, Maria Francisca, Wang, Lin, Ravid, Tommer, Hochstrasser, Mark, Canessa, Cecilia M.

“…Serum-and glucocorticoid-induced kinase 1 (Sgkl) regulates many ion channels and transporters in epithelial cells and promotes cell survival under stress…”
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brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons by Arteaga, Maria F, Coric, Tatjana, Straub, Christoph, Canessa, Cecilia M

“…Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that…”
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Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system by Rosa, Diego Alvarez, Krueger, Stefan R., Kolar, Annette, Shao, Deren, Fitzsimonds, Reiko Maki, Canessa, Cecilia M.

“…The acid-sensitive ion channel ASIC1 is a proton-gated ion channel from the mammalian nervous system. Its expression in sensory neurons and activation by low…”
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Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation by Gu, Wenxue, Zheng, Hongyan, Canessa, Cecilia M.

“…The serum- and glucocorticoid-induced kinase 1 (SGK1) promotes cell survival under stress conditions and facilitates the emergence of drug resistance in…”
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Functional Implications of the Localization and Activity of Acid-Sensitive Channels in Rat Peripheral Nervous System by de la Rosa, Diego Alvarez, Zhang, Ping, Shao, Deren, White, Fletcher, Canessa, Cecilia M.

“…Acid-sensitive ion channels (ASIC) are proton-gated ion channels expressed in neurons of the mammalian central and peripheral nervous systems. The functional…”
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Structure and regulation of amiloride-sensitive sodium channels by Alvarez de la Rosa, D, Canessa, C M, Fyfe, G K, Zhang, P

“…Amiloride-sensitive Na+ channels constitute a new class of proteins known as the ENaC-Deg family of ion channels. All members in this family share a common…”
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Effects of aldosterone on biosynthesis, traffic, and functional expression of epithelial sodium channels in A6 cells by Alvarez de la Rosa, Diego, Li, Hui, Canessa, Cecilia M

“…The collecting duct regulates Na(+) transport by adjusting the abundance/activity of epithelial Na(+) channels (ENaC). In this study we have investigated the…”
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The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression by González-Fernández, Rebeca, Ávila, Julio, Arteaga, María F, Canessa, Cecilia M, Martín-Vasallo, Pablo

“…The Serum- and Glucocorticoid-induced Kinase 1, SGK1, exhibits a broad range of cellular functions that include regulation of the number of ion channels in…”
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Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1 by Arteaga, Maria Francisca, Alvarez de la Rosa, Diego, Alvarez, Jose A, Canessa, Cecilia M

“…Serum- and glucocorticoid-induced kinase 1 is a ubiquitous kinase that regulates diverse processes such as ion transport and cell survival. We report that a…”
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Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism by Zhang, Ping, Sigworth, Fred J, Canessa, Cecilia M

“…The acid-sensitive ion channels (ASICs) are a family of voltage-insensitive sodium channels activated by external protons. A previous study proposed that the…”
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An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization by Chen, Zhuyuan, Kuenze, Georg, Meiler, Jens, Canessa, Cecilia M

“…Acid-sensing ion channels (ASICs) respond to changes in pH in the central and peripheral nervous systems and participate in synaptic plasticity and pain…”
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Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel by Coric, Tatjana, Zheng, Deyou, Gerstein, Mark, Canessa, Cecilia M.

“…The acid-sensitive ion channel 1 (ASIC1) is a neuronal Na + channel insensitive to changes in membrane potential but is gated by external protons. Proton…”
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Simple chordates exhibit a proton-independent function of acid-sensing ion channels by Coric, Tatjana, Passamaneck, Yale J, Zhang, Ping, Di Gregorio, Anna, Canessa, Cecilia M

“…Acid-sensing ion channels (ASICs) constitute a family of neuron-specific voltage-insensitive sodium channels gated by extracellular protons. Functions of ASICs…”
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Amiloride-sensitive epithelial Na + channel is made of three homologous subunits by Canessa, Cecilia M, Schild, Laurent, Buell, Gary, Thorens, Bernard, Gautschi, Ivan, Horisberger, Jean-Daniel, Rossier, Bernard C

“…The amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of…”
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Lipid droplets and autophagosomes together with chaperones fine‐tune expression of SGK1 by Ghani, Madiha J., Gu, Wenxue, Chen, Zhuyuan, Canessa, Cecilia M.

“…Serum‐glucocorticoid‐induced kinase‐1 (SGK1) regulates ion homeostasis and promotes survival under stress conditions. The expression of SGK1 is under…”
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