Search Results - "Canela, Enric"

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors by Viñals, Xavier, Moreno, Estefanía, Lanfumey, Laurence, Cordomí, Arnau, Pastor, Antoni, de La Torre, Rafael, Gasperini, Paola, Navarro, Gemma, Howell, Lesley A, Pardo, Leonardo, Lluís, Carmen, Canela, Enric I, McCormick, Peter J, Maldonado, Rafael, Robledo, Patricia

“…Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis…”
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Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes by Navarro, Gemma, Varani, Katia, Reyes-Resina, Irene, Sánchez de Medina, Verónica, Rivas-Santisteban, Rafael, Sánchez-Carnerero Callado, Carolina, Vincenzi, Fabrizio, Casano, Salvatore, Ferreiro-Vera, Carlos, Canela, Enric I., Borea, Pier Andrea, Nadal, Xavier, Franco, Rafael

“…Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. that is attracting pharmacological interest because it is…”
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Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase by Navarro, Gemma, Cordomí, Arnau, Casadó-Anguera, Verónica, Moreno, Estefanía, Cai, Ning-Sheng, Cortés, Antoni, Canela, Enric I., Dessauer, Carmen W., Casadó, Vicent, Pardo, Leonardo, Lluís, Carme, Ferré, Sergi

“…G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one of the most studied transmembrane cell signaling pathways. However, it…”
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Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System-Implications for Health and Disease by Moreno, Estefanía, Cavic, Milena, Canela, Enric I

“…The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with other…”
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Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors by Martínez-Pinilla, Eva, Varani, Katia, Reyes-Resina, Irene, Angelats, Edgar, Vincenzi, Fabrizio, Ferreiro-Vera, Carlos, Oyarzabal, Julen, Canela, Enric I., Lanciego, José L., Nadal, Xavier, Navarro, Gemma, Borea, Pier Andrea, Franco, Rafael

“…The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa L., is not completely understood. First assumed that the…”
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The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet? by Moreno, Estefanía, Cavic, Milena, Krivokuca, Ana, Casadó, Vicent, Canela, Enric

“…The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last decade. The immense data load published on its dual role in both…”
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Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases by Reyes-Resina, Irene, Navarro, Gemma, Aguinaga, David, Canela, Enric I., Schoeder, Clara T., Załuski, Michał, Kieć-Kononowicz, Katarzyna, Saura, Carlos A., Müller, Christa E., Franco, Rafael

“…[Display omitted] GPR18, still considered an orphan receptor, may respond to endocannabinoids, whose canonical receptors are CB1 and CB2. GPR18 and CB2…”
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Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain by Callén, Lucía, Moreno, Estefanía, Barroso-Chinea, Pedro, Moreno-Delgado, David, Cortés, Antoni, Mallol, Josefa, Casadó, Vicent, Lanciego, José Luis, Franco, Rafael, Lluis, Carmen, Canela, Enric I., McCormick, Peter J.

“…Exploring the role of cannabinoid CB2 receptors in the brain, we present evidence of CB2 receptor molecular and functional interaction with cannabinoid CB1…”
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Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain by Navarro, Gemma, Cordomi, Arnau, Brugarolas, Marc, Moreno, Estefania, Aguinaga, David, Pnrez-Benito, Laura, Ferre, Sergi, Cortns, Antoni, Casado, Vicent, Mallol, Josefa, Canela, Enric I, Lluis, Carme, Pardo, Leonardo, McCormick, Peter J, Franco, Rafael

“…BACKGROUNDG-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities…”
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Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists by Orru, Marco, Bakešová, Jana, Brugarolas, Marc, Quiroz, César, Beaumont, Vahri, Goldberg, Steven R., Lluís, Carme, Cortés, Antoni, Franco, Rafael, Casadó, Vicent, Canela, Enric I., Ferré, Sergi

“…Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons (MSNs) of the indirect efferent pathway, where they heteromerize with…”
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Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia by Navarro, Gemma, Borroto-Escuela, Dasiel, Angelats, Edgar, Etayo, Íñigo, Reyes-Resina, Irene, Pulido-Salgado, Marta, Rodríguez-Pérez, Ana I., Canela, Enric I., Saura, Josep, Lanciego, José Luis, Labandeira-García, José Luis, Saura, Carlos A., Fuxe, Kjell, Franco, Rafael

“…•LPS plus interferon-γ upregulate CB2 receptors in microglia.•LPS plus interferon-γ upregulate CB1-CB2 receptor complexes in microglia.•ß amyloid and LPS plus…”
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l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies by Pinna, Annalisa, Bonaventura, Jordi, Farré, Daniel, Sánchez, Marta, Simola, Nicola, Mallol, Josefa, Lluís, Carme, Costa, Giulia, Baqi, Younis, Müller, Christa E., Cortés, Antoni, McCormick, Peter, Canela, Enric I., Martínez-Pinilla, Eva, Lanciego, José L., Casadó, Vicent, Armentero, Marie-Therese, Franco, Rafael

“…Long-term therapy with l-3,4-dihydroxyphenylalanine (l-DOPA), still the most effective treatment in Parkinson's disease (PD), is associated with severe motor…”
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Nk3R blockade has sex-divergent effects on memory in mice by Florido, Antonio, Moreno, Estefanía, Canela, Enric I, Andero, Raül

“…Memory consolidation is a process required for the formation of long-term memories. The G-protein-coupled receptor (GPCR) neurokinin-3-receptor (Nk3R) and its…”
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Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling by Moreno, Estefanía, Andradas, Clara, Medrano, Mireia, Caffarel, María M., Pérez-Gómez, Eduardo, Blasco-Benito, Sandra, Gómez-Cañas, María, Pazos, M. Ruth, Irving, Andrew J., Lluís, Carme, Canela, Enric I., Fernández-Ruiz, Javier, Guzmán, Manuel, McCormick, Peter J., Sánchez, Cristina

“…The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids…”
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The Interplay between Cancer Biology and the Endocannabinoid System—Significance for Cancer Risk, Prognosis and Response to Treatment by Moreno, Estefanía, Cavic, Milena, Krivokuca, Ana, Canela, Enric I.

“…The various components of the endocannabinoid system (ECS), such as the cannabinoid receptors (CBRs), cannabinoid ligands, and the signalling network behind…”
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The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls by Costas-Insua, Carlos, Hermoso-López, Alba, Moreno, Estefanía, Montero-Fernández, Carlos, Álvaro-Blázquez, Alicia, Maroto, Irene B, Sánchez-Ruiz, Andrea, Diez-Alarcia, Rebeca, Blázquez, Cristina, Morales, Paula, Canela, Enric I, Casadó, Vicent, Urigüen, Leyre, Perea, Gertrudis, Bellocchio, Luigi, Rodríguez-Crespo, Ignacio, Guzmán, Manuel

“…Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause…”
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Therapeutic targeting of HER2–CB₂R heteromers in HER2-positive breast cancer by Blasco-Benito, Sandra, Moreno, Estefanía, Seijo-Vila, Marta, Tundidor, Isabel, Andradas, Clara, Caffarel, María M., Caro-Villalobos, Miriam, Urigüen, Leyre, Diez-Alarcia, Rebeca, Moreno-Bueno, Gema, Hernández, Lucía, Manso, Luis, Homar-Ruano, Patricia, McCormick, Peter J., Bibic, Lucka, Bernadó-Morales, Cristina, Arribas, Joaquín, Canals, Meritxell, Casadό, Vicent, Canela, Enric I., Guzmán, Manuel, Pérez-Gómez, Eduardo, Sánchez, Cristina

“…Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer…”
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Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain by Costas-Insua, Carlos, Moreno, Estefanía, Maroto, Irene B, Ruiz-Calvo, Andrea, Bajo-Grañeras, Raquel, Martín-Gutiérrez, David, Diez-Alarcia, Rebeca, Vilaró, M Teresa, Cortés, Roser, García-Font, Nuria, Martín, Ricardo, Espina, Marc, Botta, Joaquín, Ginés, Silvia, McCormick, Peter J, Sánchez-Prieto, José, Galve-Roperh, Ismael, Mengod, Guadalupe, Urigüen, Leyre, Marsicano, Giovanni, Bellocchio, Luigi, Canela, Enric I, Casadó, Vicent, Rodríguez-Crespo, Ignacio, Guzmán, Manuel

“…Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing…”
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Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum by Moreno, Estefanía, Chiarlone, Anna, Medrano, Mireia, Puigdellívol, Mar, Bibic, Lucka, Howell, Lesley A, Resel, Eva, Puente, Nagore, Casarejos, María J, Perucho, Juan, Botta, Joaquín, Suelves, Nuria, Ciruela, Francisco, Ginés, Silvia, Galve-Roperh, Ismael, Casadó, Vicent, Grandes, Pedro, Lutz, Beat, Monory, Krisztina, Canela, Enric I, Lluís, Carmen, McCormick, Peter J, Guzmán, Manuel

“…The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper…”
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Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer by Guitart, Xavier, Navarro, Gemma, Moreno, Estefania, Yano, Hideaki, Cai, Ning-Sheng, Sánchez-Soto, Marta, Kumar-Barodia, Sandeep, Naidu, Yamini T, Mallol, Josefa, Cortés, Antoni, Lluís, Carme, Canela, Enric I, Casadó, Vicent, McCormick, Peter J, Ferré, Sergi

“…The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies…”
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