Search Results - "Candy, Geoffrey"

Breast Cancer Cells Induce a Pro-inflammatory Response to Mitigate Immune Mediation in a 3D Culture Model by AUGUSTINE, TANYA N., DUARTE, RAQUEL, CANDY, GEOFFREY P.

“…Background: Growth factors and cytokines mediate complex interactions between cells within the breast tumour microenvironment. In advanced cancer, an excess of…”
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Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer by Augustine, Tanya N., Dix-Peek, Thérèse, Duarte, Raquel, Candy, Geoffrey P.

“…Three-dimensional (3D) culture approaches to investigate breast tumour progression are yielding information more reminiscent of the in vivo microenvironment…”
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SWATH-MS based proteomic profiling of pancreatic ductal adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways by Nweke, Ekene Emmanuel, Naicker, Previn, Aron, Shaun, Stoychev, Stoyan, Devar, John, Tabb, David L, Omoshoro-Jones, Jones, Smith, Martin, Candy, Geoffrey

“…Pancreatic cancer accounts for 2.8% of new cancer cases worldwide and is projected to become the second leading cause of cancer-related deaths by 2030…”
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Comparative immune profiling of pancreatic ductal adenocarcinoma progression among South African patients by Elebo, Nnenna, Abdel-Shafy, Ebtesam A, Omoshoro-Jones, Jones A O, Nsingwane, Zanele, Hussein, Ahmed A A, Smith, Martin, Candy, Geoffrey, Cacciatore, Stefano, Fru, Pascaline, Nweke, Ekene Emmanuel

“…Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer characterized by an immunosuppressive microenvironment. Patients from specific ethnicities and…”
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Transient Expression of Interleukin-21 in the Second Hit of Acute Pancreatitis May Potentiate Immune Paresis in Severe Acute Pancreatitis by Thomson, John-Edwin, Nweke, Ekene E, Brand, Martin, Nel, Marietha, Candy, Geoffrey P, Fonteh, Pascaline N

“…Interleukin-21 (IL-21) is a cytokine associated with tissue inflammation, autoimmune and infectious diseases. Organ dysfunction and death can occur in patients…”
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Antimicrobial activity and toxicity profile of selected southern African medicinal plants against neglected gut pathogens by Shirinda, Hlambani, Candy, Geoffrey, Leonard, Carmen, van Vuuren, Sandy

“…Anaerobes outnumber aerobic bacteria in the human gut. The most commonly isolated microorganisms in intra-abdominal infections include Escherichia coli,…”
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Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review) by Elebo, Nnenna, Fru, Pascaline, Omoshoro-Jones, Jones, Patrick Candy, Geoffrey, Nweke, Ekene Emmanuel

“…Pancreatic cancer is an aggressive cancer, making it a leading cause of cancer‑related deaths. It is characteristically resistant to treatment, which results…”
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Cystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy by Seape, Tebogo, Gounden, Verena, van Deventer, Hendrick E, Candy, Geoffrey P, George, Jaya A

“…We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured…”
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Enuresis in South African children: prevalence, associated factors and parental perception of treatment by Fockema, Margaret W., Candy, Geoffrey P., Kruger, Deirdré, Haffejee, Mohamed

“…Study Type – Symptom Prevalence (prospective cohort) Level of Evidence 2a What's known on the subject? and What does the study add? Nocturnal enuresis is a…”
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Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry by Elebo, Nnenna, Omoshoro-Jones, Jones, Fru, Pascaline N., Devar, John, De Wet van Zyl, Christiaan, Vorster, Barend Christiaan, Smith, Martin, Cacciatore, Stefano, Zerbini, Luiz F., Candy, Geoffrey, Nweke, Ekene Emmanuel

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a characteristic dysregulated metabolism. Abnormal clinicopathological features linked to…”
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Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance by Xelwa, Ntombikayise, Candy, Geoffrey Patrick, Devar, John, Omoshoro-Jones, Jones, Smith, Martin, Nweke, Ekene Emmanuel

“…Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as…”
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Peripartum cardiomyopathy: analysis of clinical outcome, left ventricular function, plasma levels of cytokines and Fas/APO-1 by Sliwa, Karen, Skudicky, Daniel, Bergemann, Anette, Candy, Geoffrey, Puren, Adrian, Sareli, Pinhas

“…OBJECTIVES 1) To evaluate the outcome of patients with peripartum cardiomyopathy (PPC) on current treatment for heart failure, 2) to assess the circulating…”
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Modeling of Cellular Arginine Uptake by More Than One Transporter by Nel, Marietha J., Woodiwiss, Angela J., Candy, Geoffrey P.

“…Determining the kinetic constants of arginine uptake by endothelial cells mediated by more than one transporter from linearization of data as Eadie-Hofstee…”
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Assessment of the medial head of the gastrocnemius muscle in functional compression of the popliteal artery by Pillai, Jayandiran, MBBCh, BSc, FCS, CVS, Levien, Lewis J., FCS (SA), PhD (Med), Haagensen, Mark, MBBch, FC Rad (DSA), Candy, Geoffrey, PhD, Cluver, Michelle D.V., (BSc HONs), Veller, Martin G., FCS (SA)

“…Objective Nonfunctional popliteal entrapment is due to embryologic maldevelopment within the popliteal fossa. Functional entrapment occurs in the apparent…”
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Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension by TIAGO, Armindo D, SAMANI, Nilesh J, CANDY, Geoffrey P, BROOKSBANK, Richard, LIBHABER, Elena N, SARELI, Pinhas, WOODIWISS, Angela J, NORTON, Gavin R

“…The extent to which genes modify the relationship between risk factors for hypertension and blood pressure (BP) is unclear. As angiotensinogen is expressed in…”
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Prevalence of residual left ventricular structural changes after one year of antihypertensive treatment in patients of African descent: role of 24-hour pulse pressure by Libhaber, Elena N, Norton, Gavin R, Libhaber, Carlos D, Woodiwiss, Angela J, Candy, Geoffrey P, Essop, Mohammed R, Sareli, Pinhas

“…One year of antihypertensive therapy may normalise left ventricular (LV) structure in 51% of hypertensive patients of European descent. Whether similar effects…”
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Functional variants of the angiotensinogen gene determine antihypertensive responses to angiotensin-converting enzyme inhibitors in subjects of African origin by Woodiwiss, Angela J, Nkeh, Benedicta, Samani, Nilesh J, Badenhorst, Danelle, Maseko, Muzi, Tiago, Armindo D, Candy, Geoffrey P, Libhaber, Elena, Sareli, Pinhas, Brooksbank, Richard, Norton, Gavin R

“…OBJECTIVETo determine whether the response to angiotensin-converting enzyme inhibitor (ACEI) monotherapy in subjects of African origin is determined by genetic…”
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Lavage drain extension for local anaesthetic instillation into abdominal wounds by Widgerow, Alan D, Wittstock, Craig, Candy, Geoffrey P

“…A new device made by ThebeMedicare allows efficient local anaesthetic washout of wound areas, by utilising an attachment to an existing drain. The aim of this…”
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An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy by Tiago, Armindo D., Badenhorst, Danelle, Skudicky, Daniel, Woodiwiss, Angela J., Candy, Geoffrey P., Brooksbank, Richard, Sliwa, Karen, Sareli, Pinhas, Norton, Gavin R.

“…Objective: To assess whether renin–angiotensin–aldosterone (RAA) system gene polymorphisms shown to be associated with alterations in the activity of the…”
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Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent by Naidoo, Cameron, Cromarty, Alan D., Snyman, Tracy, Sliwa, Karen, Libhaber, Elena, Essop, Mohammed R., Candy, Geoffrey P.

“…Oral supplementation with the amino acid arginine, the precursor of the vasodilator nitric oxide (NO), is associated with a reduction in blood pressure (BP)…”
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