Search Results - "Candelore, Mari Rios"

A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects by QURESHI, Sajjad A, CANDELORE, Mari Rios, GUOQIANG JIANG, BRADY, Ed, SAPERSTEIN, Richard, DUFFY, Joseph L, TATA, James R, CHAPMAN, Kevin T, MOLLER, David E, ZHANG, Bei B, DAN XIE, XIAODONG YANG, TOTA, Laurie M, DING, Victor D.-H, ZHIHUA LI, BANSAL, Alka, MILLER, Corin, COHEN, Sheila M

“…A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects Sajjad A. Qureshi 1 , Mari Rios Candelore 1 , Dan Xie 1 , Xiaodong Yang 1 ,…”
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Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists by Dallas-Yang, Qing, Shen, Xiaolan, Strowski, Mathias, Brady, Edward, Saperstein, Richard, Gibson, Raymond E., Szalkowski, Deborah, Qureshi, Sajjad A., Candelore, Mari Rios, Fenyk-Melody, Judith E., Parmee, Emma R., Zhang, Bei B., Jiang, Guoqiang

“…Glucagon receptor antagonists have been actively pursued as potential therapeutics for the treatment of type 2 diabetes. Peptidyl and non-peptidyl glucagon…”
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Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist by Mu, James, Qureshi, Sajjad A, Brady, Edward J, Muise, Eric S, Candelore, Mari Rios, Jiang, Guoqiang, Li, Zhihua, Wu, Margaret S, Yang, Xiaodong, Dallas-Yang, Qing, Miller, Corey, Xiong, Yusheng, Langdon, Ronald B, Parmee, Emma R, Zhang, Bei B

“…Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to…”
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Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor by Liang, Rui, Abrardo, Lauren, Brady, Edward J., Candelore, Mari Rios, Ding, Victor, Saperstein, Richard, Tota, Laurie M., Wright, Michael, Mock, Steve, Tamvakopolous, Constantin, Tong, Sharon, Zheng, Song, Zhang, Bei B., Tata, James R., Parmee, Emma R.

“…A series of conformationally constrained tri-substituted ureas (arrow indicates the position for conformation constraint in the Figure) were synthesized and…”
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Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor by Duffy, Joseph L., Kirk, Brian A., Konteatis, Zenon, Campbell, Elizabeth L., Liang, Rui, Brady, Edward J., Candelore, Mari Rios, Ding, Victor D.H., Jiang, Guoqiang, Liu, Frank, Qureshi, Sajjad A., Saperstein, Richard, Szalkowski, Deborah, Tong, Sharon, Tota, Lauri M., Xie, Dan, Yang, Xiaodong, Zafian, Peter, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R.

“…A novel class of antagonists of the human glucagon receptor (hGCGR) has been discovered. An SAR exploration of the lead class resulted in 13, which exhibited…”
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor by Rios Candelore, Mari, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M

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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists by Shen, Dong-Ming, Zhang, Fengqi, Brady, Edward J., Candelore, Mari Rios, Dallas-Yang, Qing, Ding, Victor D.-H., Dragovic, Jasminka, Feeney, William P., Jiang, Guoquiang, McCann, Peggy E., Mock, Steve, Qureshi, Sajjad A., Saperstein, Richard, Shen, Xiaolan, Tamvakopoulos, Constantin, Tong, Xinchun, Tota, Laurie M., Wright, Michael J., Yang, Xiaodong, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R., Parmee, Emma R.

“…The discovery and SAR study of a novel spiro-urea series of human glucagon receptor antagonists such as 15 are presented. A novel class of spiro-ureas has been…”
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Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies by Gimenez-Gallego, Guillermo, Rodkey, John, Bennett, Carl, Rios-Candelore, Mari, DiSalvo, Jerry, Thomas, Kenneth

“…Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The…”
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Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor by Fletcher, D S, Candelore, M R, Grujic, D, Lowell, B B, Luell, S, Susulic, V S, Macintyre, D E

“…The effects of beta-3 adrenergic receptor (beta3-AR) agonists on gastrointestinal (GI) motility, as reported by stomach retention and intestinal transit of…”
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor by Candelore, Mari Rios, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M

“…It has been reported recently that the phosphorylated form of the immunomodulator FTY720 activates sphingosine 1-phosphate G protein-coupled receptors…”
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Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor by Cohen, Sheila M., Duffy, Joseph L., Miller, Corin, Kirk, Brian A., Candelore, Mari Rios, Ding, Victor D.H., Kaczorowski, Gregory, Tota, Laurie M., Werrmann, Jeffrey G., Wright, Michael, Parmee, Emma R., Tata, James R., Zhang, Bei B.

“…The biosynthesis of [ 13C]glycogen from [ 13C]pyruvate via the gluconeogenic pathway is monitored in surgically removed perfused livers by 13C NMR. The rapid…”
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P 4/Edg-6 receptor by Rios Candelore, Mari, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M

“…It has been reported recently that the phosphorylated form of the immunomodulator FTY720 activates sphingosine 1-phosphate G protein-coupled receptors [1,2]…”
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Identification of Residues Required for Ligand Binding to the β -adrenergic Receptor by Strader, Catherine D., Sigal, Irving S., Register, R. Bruce, Candelore, Mari Rios, Rands, Elaine, Richard A. F. Dixon

“…The functional significance of conserved polar amino acids within the putative transmembrane region of the β -adrenergic receptor (β AR) was examined by…”
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Acute effect of ephedrine on 24-h energy balance by Shannon, J R, Gottesdiener, K, Jordan, J, Chen, K, Flattery, S, Larson, P J, Candelore, M R, Gertz, B, Robertson, D, Sun, M

“…Ephedrine is used to help achieve weight control. Data on its true efficacy and mechanisms in altering energy balance in human subjects are limited. We aimed…”
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Ligand binding to the β -adrenergic receptor involves its rhodopsin-like core by Dixon, Richard A. F, Sigal, Irving S, Rands, Elaine, Register, R. Bruce, Candelore, Mari Rios, Blake, Allan D, Strader, Catherine D

“…Recently the genes for several hormone receptors that interact with guanine nucleotide binding proteins (G proteins) have been cloned, including the hamster…”
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L-750355, a human ß3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey by Forrest, Michael J, Hom, Gary, Bach, Tom, Candelore, Mari Rios, Cascieri, Margaret A, Strader, Catherine, Tota, Laurie, Fisher, Michael H, Szumiloski, John, Ok, Hyun O, Weber, Ann E, Wyvratt, Matthew, Vicario, Pasquale, Marko, Olga, Deng, Liping, Cioffe, Christine, Hegarty-Friscino, Bonnie, MacIntyre, Euan

“…The profile of in vitro and in vivo biology of a human ß3-adrenoceptor agonist, ( S)-…”
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Pure Brain-Derived Acidic Fibroblast Growth Factor is a Potent Angiogenic Vascular Endothelial Cell Mitogen with Sequence Homology to Interleukin 1 by Thomas, Kenneth A., Rios-Candelore, Mari, Gimenez-Gallego, Guillermo, DiSalvo, Jerry, Bennett, Carl, Rodkey, John, Fitzpatrick, Susan

“…Pure bovine brain-derived acidic fibroblast growth factor is a very potent mitogen for vascular endothelial cells in culture and, in the presence of heparin,…”
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Purification and Characterization of Acidic Fibroblast Growth Factor from Bovine Brain by Thomas, Kenneth A., Rios-Candelore, Mari, Fitzpatrick, Susan

“…Acidic brain fibroblast growth factor has been purified a minimum of 35,000-fold to apparent homogeneity by a combination of differential salt precipitation,…”
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L-750355, a human β3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey by FORREST, Michael J, HOM, Gary, WEBER, Ann E, WYVRATT, Matthew, VICARIO, Pasquale, MARKO, Olga, LIPING DENG, CIOFFE, Christine, HEGARTY-FRISCINO, Bonnie, MACINTYRE, Euan, BACH, Tom, RIOS CANDELORE, Mari, CASCIERI, Margaret A, STRADER, Catherine, TOTA, Laurie, FISHER, Michael H, SZUMILOSKI, John, OK, Hyun O

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The carboxyl terminus of the hamster beta-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration by Strader, C D, Sigal, I S, Blake, A D, Cheung, A H, Register, R B, Rands, E, Zemcik, B A, Candelore, M R, Dixon, R A

“…The structural basis for agonist-mediated sequestration and desensitization of the beta-adrenergic receptor (beta AR) was examined by oligonucleotide-directed…”
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