Search Results - "Cancilla, Michael R"
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A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA
Published in Nature genetics (01-06-1997)“…We recently described a human marker chromosome containing a functional neo-centromere that binds anti-centromere antibodies, but is devoid of centromeric…”
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2
High-throughput gene mapping in Caenorhabditis elegans
Published in Genome research (01-07-2002)“…Positional cloning of mutations in model genetic systems is a powerful method for the identification of targets of medical and agricultural importance. To…”
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3
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
Published in Nature genetics (01-02-2001)“…Type 1 diabetes (T1D; or insulin-dependent diabetes mellitus, IDDM) is an autoimmune disease with both genetic and environmental components. In addition to the…”
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4
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors
Published in Cancer cell (01-04-2005)“…A chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs). Treatment with these FTIs caused…”
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Centromere Protein B Null Mice Are Mitotically and Meiotically Normal but Have Lower Body and Testis Weights
Published in The Journal of cell biology (20-04-1998)“…CENP-B is a constitutive centromere DNA-binding protein that is conserved in a number of mammalian species and in yeast. Despite this conservation, earlier…”
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Sequence Analysis of an 80 kb Human Neocentromere
Published in Human molecular genetics (01-02-1999)“…We previously described the cloning of an 80 kb DNA corresponding to the core protein-binding domain of a human chromosome 10-derived neocentromere. Here we…”
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Construction of Neocentromere-Based Human Minichromosomes by Telomere-Associated Chromosomal Truncation
Published in Proceedings of the National Academy of Sciences - PNAS (08-05-2001)“…Neocentromeres (NCs) are fully functional centromeres that arise ectopically in noncentromeric regions lacking α-satellite DNA. Using telomere-associated…”
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Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase
Published in Human molecular genetics (22-01-2000)“…A double-stranded 9 bp GTGAAAAAG pJ alpha sequence found in human centromeric alpha-satellite DNA and a 28 bp ATGTATATATGTGTATATAGACATAAAT tandemly repeated…”
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The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modification
Published in Genome research (01-06-2000)“…We have previously localized the core centromere protein-binding domain of a 10q25.2-derived neocentromere to an 80-kb genomic region. Detailed analysis has…”
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Specific isolation of human rDNA genes by TAR cloning
Published in Gene (15-09-1997)“…Selective cloning of human DNA in YACs from monochromosomal human/rodent hybrid cells lines and radiation hybrids can be accomplished by…”
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Direct Cloning of Human 10q25 Neocentromere DNA Using Transformation-Associated Recombination (TAR) in Yeast
Published in Genomics (San Diego, Calif.) (01-02-1998)“…The transformation-associated recombination (TAR) procedure allows rapid, site-directed cloning of specific human chromosomal regions as yeast artificial…”
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12
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4
Published in Gene (27-11-2000)“…Members of the suppressor of cytokine signalling (SOCS) family of proteins have been shown to inhibit cytokine signalling via direct interactions with JAK…”
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Rapid Genomic Fingerprinting of Lactococcus lactis Strains by Arbitrarily Primed Polymerase Chain Reaction with (32)P and Fluorescent Labels
Published in Applied and environmental microbiology (01-05-1992)“…Arbitrarily primed polymerase chain reaction, with incorporation of either radioactive or fluorescent labels, was used as a rapid and sensitive method for…”
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Lactococcus lactis glyceraldehyde-3-phosphate dehydrogenase gene, gap: further evidence for strongly biased codon usage in glycolytic pathway genes
Published in Microbiology (Society for General Microbiology) (01-04-1995)“…Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia Commonwealth Scientific and Industrial Research…”
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The Lactococcus lactis triosephosphate isomerase gene, tpi, is monocistronic
Published in Microbiology (Society for General Microbiology) (01-01-1995)“…1 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia 2 Commonwealth Scientific and Industrial Research…”
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