Search Results - "Cancer treatment and research communications"

Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review by Rizzo, Alessandro, Brandi, Giovanni

“…•Although radical surgical resection represents the only potentially curative treatment for cholangiocarcinoma, the majority of patients is diagnosed with…”
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Chemotherapy-Induced Nausea and Vomiting: Pathogenesis, Recommendations, and New Trends by Gupta, Kush, Walton, Rebecca, Kataria, S.P.

“…•CINV leading to advers effects, morbidity and treatment interruptions/defaults.•Pathophysiology of CINV.•Treatment options and Mangement guidelines.•Unmet…”
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Pemigatinib: Hot topics behind the first approval of a targeted therapy in cholangiocarcinoma by Rizzo, Alessandro, Ricci, Angela Dalia, Brandi, Giovanni

“…•Unfortunately, although recent years have witnessed the advent of novel therapeutic options, patients with advanced cholangiocarcinoma (CCA) face a…”
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First-line Chemotherapy in Advanced Biliary Tract Cancer Ten Years After the ABC-02 Trial: “And Yet It Moves!” by Rizzo, Alessandro, Brandi, Giovanni

“…•In 2010, the pivotal phase III ABC-02 trial established the doublet cisplatin plus gemcitabine as standard first-line therapy in treatment-naïve patients with…”
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Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis by Chen, Tengfei, Liu, Yali, Li, Chang, Xu, Chun, Ding, Cheng, Chen, Jun, Zhao, Jun

“…•Exosomal circRNA induces M2 polarization by activating PI3K/AKT signaling pathway.•M2 macrophages enhances EMT and metastasis.•CircFARSA promotes PTEN…”
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Ins and outs of cadmium-induced carcinogenesis: Mechanism and prevention by Cui, Zheng-Guo, Ahmed, Kanwal, Zaidi, Syed Faisal, Muhammad, Jibran Sualeh

“…•Cadmium (Cd), a toxic environmental pollutant, have numerous undesirable effects on human health.•Reactive oxygen species (ROS) often play an important role…”
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Role of immunotherapy in bladder cancer by Rhea, Logan P., Mendez-Marti, Sebastian, Kim, Davis, Aragon-Ching, Jeanny B.

“…•Checkpoint inhibitors are an established treatment for second-line therapy in metastatic urothelial cancers.•Maintenance therapy with avelumab after complete…”
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Tumor angiogenesis: Current challenges and therapeutic opportunities by Al-Ostoot, Fares Hezam, Salah, Salma, Khamees, Hussien Ahmed, Khanum, Shaukath Ara

“…•The article describes cancer angiogenesis, types, and classifications.•The mechanism of angiogenesis in cancer has been addressed.•Common growth factors and…”
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The use of heparin and heparin-like molecules in cancer treatment: a review by Atallah, Johnny, Khachfe, Hussein H., Berro, Juliett, Assi, Hazem I.

“…•Heparin and heparin-like molecules are new molecules being used in cancer treatment.•These molecules have been found to several cancers such as multiple…”
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Immunotherapy in head and neck squamous cell carcinoma: An updated review by Parmar, K., Mohamed, A., Vaish, E., Thawani, R., Cetnar, J., Thein, K.Z.

“…•There are growing efforts to characterize the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC) in order to carefully select patients…”
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Utilization of systemic therapy for treatment of advanced urothelial carcinoma: Lessons from real world experience by Swami, Umang, Grivas, Petros, Pal, Sumanta K., Agarwal, Neeraj

“…•Potential ways to maximize receipt of systemic therapies and overcome high attrition rate in patients with metastatic urothelial carcinoma: -.•Preventing or…”
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Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients by de Kock, Remco, Borne, Ben van den, Soud, Maggy Youssef- El, Belderbos, Huub, Stege, Gerben, de Saegher, Marleen, van Dongen-Schrover, Claartje, Genet, Sylvia, Brunsveld, Luc, Scharnhorst, Volkher, Deiman, Birgit

“…•Serial testing of ctDNA could complement radiographic therapy response monitoring and guide the imaging frequency of lung cancer patients•ctDNA and Cyfra21-1…”
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Cancer patients and COVID-19: Mortality, serious complications, biomarkers, and ways forward by Gupta, Kush, Gandhi, Shipra, Mebane, Alexander, Singh, Angelica, Vishnuvardhan, Nivetha, Patel, Eshan

“…•Cardiovascular complicatons in COVID-positive cancer atients.•Role of certain biomarkers, including CRP, IL-6 and others in cancer patients with…”
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Dietary acid load and lung cancer risk: A case-control study in men by Ronco, Alvaro L., Martínez-López, Wilner, Calderón, Juan M., Golomar, Wilson

“…•Dysregulation of acid-base balance can contribute to inflammation and cancer development.•There is scarce epidemiologic evidence linking diet-dependent acid…”
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IDH inhibitors in advanced cholangiocarcinoma: Another arrow in the quiver? by Rizzo, Alessandro, Ricci, Angela Dalia, Brandi, Giovanni

“…•In the last decade, the advent of genomic profiling has led to the identification of several putative actionable aberrations in cholangiocarcinomas (CCAs),…”
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Breast cancer risk prediction in African women using Random Forest Classifier by Macaulay, Babafemi Oluropo, Aribisala, Benjamin Segun, Akande, Soji Alabi, Akinnuwesi, Boluwaji Ade, Olabanjo, Olusola Aanu

“…•Proper risk assessment is very important at reducing mortality related to breast cancer.•There is no breast cancer predictive model developed for African…”
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Real-world patterns of biomarker testing and targeted therapy in de novo metastatic non-small cell lung cancer patients in the US oncology network by Nadler, Eric, Vasudevan, Anupama, Wang, Yunfei, Ogale, Sarika

“…•Nearly 50% of biomarker-tested patients did not have biomarker test results prior to 1L treatment.•Fewer than 20% of biomarker-tested patients had results for…”
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Clinical and pathological differences between early- and late-onset colorectal cancer and determinants of one-year all-cause mortality among advanced-stage patients: a retrospective cohort study in Medellín, Colombia by Ruiz-Grajales, Álvaro Esteban, Orozco-Puerta, Manuela María, Zheng, Senshuang, H․ de Bock, Geertruida, Correa-Cote, Juan Camilo, Castrillón-Martínez, Esteban

“…•Clinical profile of colorectal cancer (CRC) is different based on age of onset.•CRC in younger patients is often sporadic and located in the rectum.•CRC in…”
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Hyperthermic intraperitoneal chemotherapy (HIPEC) after primary debulking surgery in advanced epithelial ovarian cancer: Is BRCA mutational status making the difference? by Ghirardi, Valentina, De Felice, Francesca, D'Indinosante, Marco, Bernardini, Federica, Giudice, Maria Teresa, Fagotti, Anna, Scambia, Giovanni

“…•HIPEC can target residual disease after cytoreductive surgery in ovarian cancer.•Evidence on molecular pattern predictive of HIPEC efficacy is lacking.•Being…”
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Emerging treatments for metastatic castration-resistant prostate cancer: Immunotherapy, PARP inhibitors, and PSMA-targeted approaches by Marshall, Catherine Handy, Antonarakis, Emmanuel S.

“…Recently there has been an explosion of new agents being investigated for the treatment of prostate cancer. These modalities represent new therapies aimed at…”
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