Search Results - "Cancer research (Chicago, Ill.)"

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells by Chang, Alan L, Miska, Jason, Wainwright, Derek A, Dey, Mahua, Rivetta, Claudia V, Yu, Dou, Kanojia, Deepak, Pituch, Katarzyna C, Qiao, Jian, Pytel, Peter, Han, Yu, Wu, Meijing, Zhang, Lingjiao, Horbinski, Craig M, Ahmed, Atique U, Lesniak, Maciej S

“…In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells…”
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CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells by Canale, Fernando P, Ramello, María C, Núñez, Nicolás, Araujo Furlan, Cintia L, Bossio, Sabrina N, Gorosito Serrán, Melisa, Tosello Boari, Jimena, Del Castillo, Andrés, Ledesma, Marta, Sedlik, Christine, Piaggio, Eliane, Gruppi, Adriana, Acosta Rodríguez, Eva A, Montes, Carolina L

“…The ability of CD8 T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset…”
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N 6 -Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma by Li, Fuxi, Yi, Yang, Miao, Yanyan, Long, Wenyong, Long, Teng, Chen, Siyun, Cheng, Weisheng, Zou, Changye, Zheng, Yueyuan, Wu, Xingui, Ding, Junjun, Zhu, Kaiyu, Chen, Delin, Xu, Qiongcong, Wang, Jinkai, Liu, Qing, Zhi, Feng, Ren, Jian, Cao, Qi, Zhao, Wei

“…The N -methyladenosine (m A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated mRNA decay…”
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Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis by Wang, Yinu, Zhao, Guangyuan, Condello, Salvatore, Huang, Hao, Cardenas, Horacio, Tanner, Edward J, Wei, JianJun, Ji, Yanrong, Li, Junjie, Tan, Yuying, Davuluri, Ramana V, Peter, Marcus E, Cheng, Ji-Xin, Matei, Daniela

“…Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and…”
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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment by Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin

“…STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many…”
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Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis by Jeong, Hoibin, Kim, Sehui, Hong, Beom-Ju, Lee, Chan-Ju, Kim, Young-Eun, Bok, Seoyeon, Oh, Jung-Min, Gwak, Seung-Hee, Yoo, Min Young, Lee, Min Sun, Chung, Seock-Jin, Defrêne, Joan, Tessier, Philippe, Pelletier, Martin, Jeon, Hyeongrin, Roh, Tae-Young, Kim, Bumju, Kim, Ki Hean, Ju, Ji Hyeon, Kim, Sungjee, Lee, Yoon-Jin, Kim, Dong-Wan, Kim, Il Han, Kim, Hak Jae, Park, Jong-Wan, Lee, Yun-Sang, Lee, Jae Sung, Cheon, Gi Jeong, Weissman, Irving L, Chung, Doo Hyun, Jeon, Yoon Kyung, Ahn, G-One

“…Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM)…”
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Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p by Xu, Jie, Meng, Qingtao, Li, Xiaobo, Yang, Hongbao, Xu, Jin, Gao, Na, Sun, Hao, Wu, Shenshen, Familiari, Giuseppe, Relucenti, Michela, Zhu, Haitao, Wu, Jiong, Chen, Rui

“…Immune dysregulation plays a vital role in colorectal cancer initiation and progression. Long noncoding RNAs (lncRNA) exhibit multiple functions including…”
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FTO-Dependent N 6 -Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling by Huang, Hao, Wang, Yinu, Kandpal, Manoj, Zhao, Guangyuan, Cardenas, Horacio, Ji, Yanrong, Chaparala, Anusha, Tanner, Edward J, Chen, Jianjun, Davuluri, Ramana V, Matei, Daniela

“…-Methyladenosine (m A) is the most abundant modification of mammalian mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The…”
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Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes by Rohani, Nazanin, Hao, Liangliang, Alexis, Maria S, Joughin, Brian A, Krismer, Konstantin, Moufarrej, Mira N, Soltis, Anthony R, Lauffenburger, Douglas A, Yaffe, Michael B, Burge, Christopher B, Bhatia, Sangeeta N, Gertler, Frank B

“…Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates tumor cell invasion by affecting immune cell function, clonal cell…”
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Replication Gaps Underlie BRCA Deficiency and Therapy Response by Panzarino, Nicholas J, Krais, John J, Cong, Ke, Peng, Min, Mosqueda, Michelle, Nayak, Sumeet U, Bond, Samuel M, Calvo, Jennifer A, Doshi, Mihir B, Bere, Matt, Ou, Jianhong, Deng, Bin, Zhu, Lihua J, Johnson, Neil, Cantor, Sharon B

“…Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemosensitivity of tumors deficient in the hereditary…”
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The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists by Thomas, Sunil, Izard, Jacques, Walsh, Emily, Batich, Kristen, Chongsathidkiet, Pakawat, Clarke, Gerard, Sela, David A, Muller, Alexander J, Mullin, James M, Albert, Korin, Gilligan, John P, DiGuilio, Katherine, Dilbarova, Rima, Alexander, Walker, Prendergast, George C

“…Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make…”
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Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity by Büll, Christian, Boltje, Thomas J, Balneger, Natasja, Weischer, Sarah M, Wassink, Melissa, van Gemst, Jasper J, Bloemendal, Victor R, Boon, Louis, van der Vlag, Johan, Heise, Torben, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor…”
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Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms by Solomon, James P, Hechtman, Jaclyn F

“…Oncogenic fusions involving , and with various partners are diagnostic of infantile fibrosarcoma and secretory carcinoma yet also occur in lower frequencies…”
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Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer by Di Modica, Martina, Gargari, Giorgio, Regondi, Viola, Bonizzi, Arianna, Arioli, Stefania, Belmonte, Beatrice, De Cecco, Loris, Fasano, Elena, Bianchi, Francesca, Bertolotti, Alessia, Tripodo, Claudio, Villani, Laura, Corsi, Fabio, Guglielmetti, Simone, Balsari, Andrea, Triulzi, Tiziana, Tagliabue, Elda

“…Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we…”
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N 6 -Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V, Showe, Louise C, Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Despite the high initial response rates to PARP inhibitors (PARPi) in -mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge…”
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The Importance of Body Composition in Explaining the Overweight Paradox in Cancer by Caan, Bette J., Cespedes Feliciano, Elizabeth M., Kroenke, Candyce H.

“…Despite a greater risk of cancer associated with higher BMI, overweight (BMI 25-<30 kg/m 2 ) and class I obese (BMI 30-<35-kg/m 2 ) patients often have a…”
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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma by Leung, Hoi Wing, Leung, Carmen Oi Ning, Lau, Eunice Y, Chung, Katherine Po Sin, Mok, Etienne H, Lei, Martina Mang Leng, Leung, Rainbow Wing Hei, Tong, Man, Keng, Vincent W, Ma, Cong, Zhao, Qian, Ng, Irene Oi Lin, Ma, Stephanie, Lee, Terence K

“…The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer…”
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Cis-acting circ-CTNNB1 promotes β-catenin signaling and cancer progression via DDX3-mediated transactivation of YY1 by Yang, Feng, Fang, Erhu, Mei, Hong, Chen, Yajun, Li, Huanhuan, Li, Dan, Song, Huajie, Wang, Jianqun, Hong, Mei, Xiao, Wenjing, Wang, Xiaojing, Huang, Kai, Zheng, Liduan, Tong, Qiangsong

“…Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and…”
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Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma by Yarchoan, Mark, Agarwal, Parul, Villanueva, Augusto, Rao, Shuyun, Dawson, Laura A, Llovet, Josep M, Finn, Richard S, Groopman, John D, El-Serag, Hashem B, Monga, Satdarshan P, Wang, Xin Wei, Karin, Michael, Schwartz, Robert E, Tanabe, Kenneth K, Roberts, Lewis R, Gunaratne, Preethi H, Tsung, Allan, Brown, Kimberly A, Lawrence, Theodore S, Salem, Riad, Singal, Amit G, Kim, Amy K, Rabiee, Atoosa, Resar, Linda, Hoshida, Yujin, He, Aiwu Ruth, Ghoshal, Kalpana, Ryan, Patrick B, Jaffee, Elizabeth M, Guha, Chandan, Mishra, Lopa, Coleman, C Norman, Ahmed, Mansoor M

“…Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally. The landscape of systemic therapy has recently changed, with six…”
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Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire by Oh, David Y, Cham, Jason, Zhang, Li, Fong, Grant, Kwek, Serena S, Klinger, Mark, Faham, Malek, Fong, Lawrence

“…While immune checkpoint blockade elicits efficacious responses in many patients with cancer, it also produces a diverse and unpredictable number of…”
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