Search Results - "Cancer medicine (Malden, MA)"

Microsatellite instability status determined by next‐generation sequencing and compared with PD‐L1 and tumor mutational burden in 11,348 patients by Vanderwalde, Ari, Spetzler, David, Xiao, Nianqing, Gatalica, Zoran, Marshall, John

“…Microsatellite instability (MSI) testing identifies patients who may benefit from immune checkpoint inhibitors. We developed an MSI assay that uses data from a…”
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LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR‐20a‐5p/HMGA2 axis in breast cancer by Zhao, Wenyan, Geng, Donghua, Li, Shuqiang, Chen, Zhaofu, Sun, Ming

“…To study the regulatory effect of lncRNA HOTAIR/miR‐20a‐5p/HMGA2 axis on breast cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The…”
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Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group by Hibbitts, Emily, Chi, Yueh‐Yun, Hawkins, Douglas S., Barr, Frederic G., Bradley, Julie A., Dasgupta, Roshni, Meyer, William H., Rodeberg, David A., Rudzinski, Erin R., Spunt, Sheri L., Skapek, Stephen X., Wolden, Suzanne L., Arndt, Carola A. S.

“…Background Previous studies of the prognostic importance of FOXO1 fusion status in patients with rhabdomyosarcoma (RMS) have had conflicting results. We…”
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Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway by Sun, Ruijie, Zhai, Ruiren, Ma, Changlin, Miao, Wei

“…Hepatocellular carcinoma (HCC) is a devastating and highly metastatic cancer worldwide. Metformin (MET) is the priority drug for treatment of type 2 diabetes;…”
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Are 90% of deaths from cancer caused by metastases? by Dillekås, Hanna, Rogers, Michael S., Straume, Oddbjørn

“…Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective…”
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Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science by Xiang, Yuening, Guo, Zimu, Zhu, Pengfei, Chen, Jia, Huang, Yongye

“…Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer…”
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Predicting biomarkers from classifier for liver metastasis of colorectal adenocarcinomas using machine learning models by Shuwen, Han, Xi, Yang, Qing, Zhou, Jing, Zhuang, Wei, Wu

“…Background Early diagnosis of liver metastasis is of great importance for enhancing the survival of colorectal adenocarcinoma (CAD) patients, and the combined…”
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Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy by Feng, Yangbo, Xiong, Yanlu, Qiao, Tianyun, Li, Xiaofei, Jia, Lintao, Han, Yong

“…Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate…”
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Phase II study (KAMELEON) of single‐agent T‐DM1 in patients with HER2‐positive advanced urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma by Vries, Elisabeth G. E., Rüschoff, Josef, Lolkema, Martijn, Tabernero, Josep, Gianni, Luca, Voest, Emile, Groot, Derk Jan A., Castellano, Daniel, Erb, Gilles, Naab, Julia, Donica, Margarita, Deurloo, Regula, Heijden, Michiel S., Viale, Giuseppe

“…The antibody‐drug conjugate trastuzumab emtansine (T‐DM1) is approved for human epidermal growth factor receptor 2 (HER2/ERBB2)–positive breast cancer. We…”
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Nrf2 in cancers: A double‐edged sword by Wu, Shijia, Lu, Hong, Bai, Yongheng

“…The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage induced by exogenous chemicals. It maintains the…”
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Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma by Rosner, Samuel, Kwong, Erica, Shoushtari, Alexander N., Friedman, Claire F., Betof, Allison S., Brady, Mary Sue, Coit, Daniel G., Callahan, Margaret K., Wolchok, Jedd D., Chapman, Paul B., Panageas, Katherine S., Postow, Michael A.

“…Both the combination of nivolumab + ipilimumab and single‐agent anti‐PD‐1 immunotherapy have demonstrated survival benefit for patients with advanced melanoma…”
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Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer by Rudra, Soumon, Jiang, Naomi, Rosenberg, Stephen A., Olsen, Jeffrey R., Roach, Michael C., Wan, Leping, Portelance, Lorraine, Mellon, Eric A., Bruynzeel, Anna, Lagerwaard, Frank, Bassetti, Michael F., Parikh, Parag J., Lee, Percy P.

“…Background Adaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can escalate dose to tumors while minimizing dose to normal tissue. We…”
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Ovarian cancer: Current status and strategies for improving therapeutic outcomes by Chandra, Ashwin, Pius, Cima, Nabeel, Madiha, Nair, Maya, Vishwanatha, Jamboor K., Ahmad, Sarfraz, Basha, Riyaz

“…Of all the gynecologic tumors, ovarian cancer (OC) is known to be the deadliest. Advanced‐stages of OC are linked with high morbidity and low survival rates…”
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Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis by Sroussi, Herve Y, Epstein, Joel B., Bensadoun, Rene‐Jean, Saunders, Deborah P., Lalla, Rajesh V., Migliorati, Cesar A., Heaivilin, Natalie, Zumsteg, Zachary S.

“…Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral…”
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Salmonella enterica serovar Typhi and gallbladder cancer: a case–control study and meta‐analysis by Koshiol, Jill, Wozniak, Aniela, Cook, Paz, Adaniel, Christina, Acevedo, Johanna, Azócar, Lorena, Hsing, Ann W., Roa, Juan C., Pasetti, Marcela F., Miquel, Juan F., Levine, Myron M., Ferreccio, Catterina, Aguayo, Carmen Gloria, Baez, Sergio, Díaz, Alfonso, Molina, Héctor, Miranda, Carolina, Castillo, Claudia, Tello, Andrea, Durán, Gonzalo, Delgado, Carolina Paz, Quevedo, Rodrigo, Pineda, Susana, la Barra, Tiare, Reyes, Cristian, Alegría, Cristina, Aguayo, Claudia, Losada, Héctor, Arraya, Juan Carlos, Bellolio, Enrique, Tapia, Oscar, López, Jaime, Medina, Karie, Barraza, Paulina, Catalán, Sandra, Riquelme, Pía, Órdenes, Lorena, Garcés, Raúl, Duarte, Claudia, Hildesheim, Allan

“…In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until the 1990s, we evaluated the association between Salmonella enterica…”
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Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer by Ibrahim, Joe, Op de Beeck, Ken, Fransen, Erik, Croes, Lieselot, Beyens, Matthias, Suls, Arvid, Vanden Berghe, Wim, Peeters, Marc, Van Camp, Guy

“…In addition to its implication in hereditary hearing loss, the Gasdermin E (GSDME) gene is also a tumor suppressor involved in cancer progression through…”
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Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies by Xia, Lin, Zhao, Rui, Wan, Qianyi, Wu, Yutao, Zhou, Yong, Wang, Yong, Cui, Yaping, Shen, Xiaoding, Wu, Xiaoting

“…Objective The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health‐related outcomes. Design An umbrella review…”
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Crosstalk between cancer and immune cells: Role of tumor‐associated macrophages in the tumor microenvironment by Wang, Jing, Li, Danyang, Cang, Huaixing, Guo, Bo

“…Tumor microenvironment is a complex system that contains multiple cells and cytokines. Among the multiple immune cells, macrophage is particularly abundant and…”
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Overexpression of the microRNA miR‐433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells by Weiner‐Gorzel, Karolina, Dempsey, Eugene, Milewska, Malgorzata, McGoldrick, Aloysius, Toh, Valerie, Walsh, Aoibheann, Lindsay, Sinead, Gubbins, Luke, Cannon, Aoife, Sharpe, Daniel, O'Sullivan, Jacintha, Murphy, Madeline, Madden, Stephen F., Kell, Malcolm, McCann, Amanda, Furlong, Fiona

“…Annually, ovarian cancer (OC) affects 240,000 women worldwide and is the most lethal gynecological malignancy. High‐grade serous OC (HGSOC) is the most common…”
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Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K‐Akt signaling in gastric cancer by Zhang, Cheng, Zhang, Mengqi, Ge, Sai, Huang, Wenwen, Lin, Xiaoting, Gao, Jing, Gong, Jifang, Shen, Lin

“…Background As the most abundant epigenetic modification on mRNAs and long non‐coding RNAs, N6‐methyladenosine (m6A) modification extensively exists in…”
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