Search Results - "Cancer gene therapy"

Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms by Tay, Rong En, Richardson, Emma K., Toh, Han Chong

“…Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming…”
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Key chemokines direct migration of immune cells in solid tumors by Kohli, Karan, Pillarisetty, Venu G., Kim, Teresa S.

“…Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by…”
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Cancer-associated fibroblasts: overview, progress, challenges, and directions by Ping, Qinrong, Yan, Ruping, Cheng, Xin, Wang, Wenju, Zhong, Yiming, Hou, Zongliu, Shi, Yunqiang, Wang, Chunhui, Li, Ruhong

“…Tumors are one of the main causes of death in humans. The development of safe and effective methods for early diagnosis and treatment of tumors is a difficult…”
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Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death by Liu, Yang, Wang, Yuan, Liu, Jiao, Kang, Rui, Tang, Daolin

“…Ferroptosis has become a topic of rapidly growing interest in recent years, and has possible therapy implications in cancer therapy. Although excessive…”
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Transcription factors in ferroptotic cell death by Dai, Chongshan, Chen, Xin, Li, Jingbo, Comish, Paul, Kang, Rui, Tang, Daolin

“…Ferroptosis, a form of regulated cell death, is characterized by an excessive degree of iron accumulation and lipid peroxidation. Although it was originally…”
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Dissecting the functional role of microRNA 21 in osteosarcoma by Sekar, Durairaj, Mani, Panagal, Biruntha, M., Sivagurunathan, P., Karthigeyan, M.

“…Osteosarcoma (OS) is considered to be a malignant bone tumour that mainly affects the long bones, but it is also involved in other bones of the body…”
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METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway by Bi, Xuehan, Lv, Xiao, Liu, Dajiang, Guo, Hongtao, Yao, Guang, Wang, Lijuan, Liang, Xiaolei, Yang, Yongxiu

“…Methyltransferase-like 3 (METTL3) functions as an RNA methyltransferase that controls the modification of N (6)-methyladenosine (m6A) to influence the…”
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The KRAS-G12C inhibitor: activity and resistance by Liu, Jiao, Kang, Rui, Tang, Daolin

“…Although it has long been deemed “undruggable”, with the development of drugs specifically binding the KRAS-G12C mutant protein, clinical trials that directly…”
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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials by Choucair, Khalil, Morand, Susan, Stanbery, Laura, Edelman, Gerald, Dworkin, Lance, Nemunaitis, John

“…Immune checkpoint inhibition (ICI) has revolutionized cancer treatment, and produced durable responses in many cancer types. However, there remains a subset of…”
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Glioblastoma: exosome and microRNA as novel diagnosis biomarkers by Saadatpour, L, Fadaee, E, Fadaei, S, Nassiri Mansour, R, Mohammadi, M, Mousavi, S M, Goodarzi, M, Verdi, J, Mirzaei, H

“…Glioblastoma (GBM) is known as a tumor type, which arises from astrocytes. Several studies indicated that GBM tumor cells are malignant. This is because of the…”
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New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles by Zaimy, M A, Saffarzadeh, N, Mohammadi, A, Pourghadamyari, H, Izadi, P, Sarli, A, Moghaddam, L K, Paschepari, S R, Azizi, H, Torkamandi, S, Tavakkoly-Bazzaz, J

“…Cancer is one of the leading cause of death in the world with the prevalence of >10 million mortalities annually. Current cancer treatments include surgical…”
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LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p /ROCK1 by Zhong, Yu, Yu, Chao, Qin, Wenyi

“…Recently, long non-coding RNAs (lncRNAs) are considered as critical regulators in pathogenesis progression of cerebral ischemia. In present study, lncRNA-small…”
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Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer by Nedaeinia, R, Manian, M, Jazayeri, M H, Ranjbar, M, Salehi, R, Sharifi, M, Mohaghegh, F, Goli, M, Jahednia, S H, Avan, A, Ghayour-Mobarhan, M

“…The most important biological function of exosomes is their possible use as biomarkers in clinical diagnosis. Compared with biomarkers identified in…”
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MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer by Lu, Y, Qin, T, Li, J, Wang, L, Zhang, Q, Jiang, Z, Mao, J

“…MicroRNAs (miRNAs) have been proven to be involved in cell metastasis and angiogenesis by interaction with the target mRNAs. Evidence has been confirmed that…”
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Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study by Sheykhhasan, Mohsen, Manoochehri, Hamed, Dama, Paola

“…Acute lymphoblastic leukemia (ALL) is a cancer-specific lymphoid cell. Induction and consolidation chemotherapy alone or in combination with different…”
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LOX-1 and cancer: an indissoluble liaison by Murdocca, M., De Masi, C., Pucci, S., Mango, R., Novelli, G., Di Natale, C., Sangiuolo, F.

“…Recently, a strong correlation between metabolic disorders, tumor onset, and progression has been demonstrated, directing new therapeutic strategies on…”
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Protein post-translational modifications in the regulation of cancer hallmarks by Wang, Haiying, Yang, Liqian, Liu, Minghui, Luo, Jianyuan

“…Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of…”
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Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy by Rezaei, Ramazan, Esmaeili Gouvarchin Ghaleh, Hadi, Farzanehpour, Mahdieh, Dorostkar, Ruhollah, Ranjbar, Reza, Bolandian, Masoumeh, Mirzaei Nodooshan, Majid, Ghorbani Alvanegh, Akbar

“…Chimeric antigen receptor (CAR) T-cell therapy is an encouraging and fast-growing platform used for the treatment of various types of tumors in human body…”
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Emerging role of exosomes as promising diagnostic tool for cancer by Jayaseelan, Vijayashree Priyadharsini

“…The incidence of cancer is experiencing a steep rise in recent times. A survey report produced by GLOBOCAN 2018 estimates about 18.1 million new cases of…”
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The V-ATPases in cancer and cell death by Chen, Fangquan, Kang, Rui, Liu, Jiao, Tang, Daolin

“…Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters that can be divided into F-, V-, and A-ATPases according to their structure. The…”
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