Search Results - "Cancer chemotherapy and pharmacology"

Advances in ovarian cancer therapy by Cortez, Alexander J., Tudrej, Patrycja, Kujawa, Katarzyna A., Lisowska, Katarzyna M.

“…Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of…”
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Platinum-based drugs: past, present and future by Dilruba, Shahana, Kalayda, Ganna V.

“…Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of human neoplasms. Their clinical success is, however, limited due…”
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Tumor microenvironment promotes breast cancer chemoresistance by Mehraj, Umar, Dar, Abid Hamid, Wani, Nissar A., Mir, Manzoor A.

“…Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis…”
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The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy by Ahlmann, Martina, Hempel, Georg

“…Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As cyclophosphamide is in clinical use for more than 40 years, there is a…”
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Disulfiram: a novel repurposed drug for cancer therapy by Lu, Chen, Li, Xinyan, Ren, Yongya, Zhang, Xiao

“…Cancer is a major health issue worldwide and the global burden of cancer is expected to reduce the costs of treatment as well as prolong the survival time. One…”
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Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells by Nicoletto, Rachel E., Ofner, Clyde M.

“…Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety of tumor types, such as breast cancer. Despite the long history of…”
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The role of thioredoxin system in cancer: strategy for cancer therapy by Jia, Jin-Jing, Geng, Wen-Shuo, Wang, Zhan-Qi, Chen, Lei, Zeng, Xian-Si

“…Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well…”
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A phase II study of modified FOLFIRINOX for chemotherapy-naïve patients with metastatic pancreatic cancer by Ozaka, Masato, Ishii, Hiroshi, Sato, Tosiya, Ueno, Makoto, Ikeda, Masafumi, Uesugi, Kazuhiro, Sata, Naohiro, Miyashita, Kouichirou, Mizuno, Nobumasa, Tsuji, Kunihiro, Okusaka, Takuji, Furuse, Junji

“…Background We evaluated the efficacy and safety of a modified FOLFIRINOX regimen for chemotherapy-naïve patients with metastatic pancreatic cancer. Methods…”
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A panel of serum exosomal microRNAs as predictive markers for chemoresistance in advanced colorectal cancer by Jin, Guoying, Liu, Yuhang, Zhang, Jia, Bian, Zehua, Yao, Surui, Fei, Bojian, Zhou, Leyuan, Yin, Yuan, Huang, Zhaohui

“…Background Chemoresistance is a common problem for cancer treatment worldwide. Circulating exosomal microRNAs (miRNAs) have been considered as promising…”
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Randomized, prospective, comparative study on the effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis by Choi, Jong Hwan, Chung, Woo Jin, Bae, Si Hyun, Song, Do Seon, Song, Myeong Jun, Kim, Young Seok, Yim, Hyung Joon, Jung, Young Kul, Suh, Sang Jun, Park, Jun Yong, Kim, Do Young, Kim, Seung Up, Cho, Sung Bum

“…Background/aims Treatment responses of advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remain unacceptably low and treatment…”
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Therapeutic drug monitoring of 5-fluorouracil by Lee, James J., Beumer, Jan H., Chu, Edward

“…Purpose For over 50 years, 5-FU has played a critical role in the systemic chemotherapy of cancer patients. 5-FU serves as the main backbone of combination…”
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Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs by Phillips, Roger M.

“…The presence of a microenvironment within most tumours containing regions of low oxygen tension or hypoxia has profound biological and therapeutic…”
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Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway by Burris, Howard A.

“…Background Most targeted anticancer therapies, as well as cytotoxic and radiation therapies, are encumbered by the development of secondary resistance by…”
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Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine by Silverman, Jeffrey A., Deitcher, Steven R.

“…Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action, demonstrated anticancer…”
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Involvement of cytochrome P450 enzymes in inflammation and cancer: a review by Stipp, Maria Carolina, Acco, Alexandra

“…Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs, xenobiotics, and endogenous substances. This enzymatic activity can be…”
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A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors by Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K., Kroll, Stewart, Jung, Donald T., Kurtoglu, Metin, Rosenblatt, Joseph, Lampidis, Theodore J.

“…Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy- d…”
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Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis by Abdel-Daim, Mohamed M., kilany, Omnia E., Khalifa, Hesham A., Ahmed, Amal A. M.

“…Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was…”
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Positioning of proteasome inhibitors in therapy of solid malignancies by Roeten, Margot S. F., Cloos, Jacqueline, Jansen, Gerrit

“…Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic…”
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The thioredoxin system and cancer therapy: a review by Mohammadi, Fariba, Soltani, Arash, Ghahremanloo, Atefeh, Javid, Hossein, Hashemy, Seyed Isaac

“…Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In…”
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Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review by Madsen, Marie Lindhard, Due, Hanne, Ejskjær, Niels, Jensen, Paw, Madsen, Jakob, Dybkær, Karen

“…Purpose Vincristine is widely used as anticancer therapy for a variety of hematological malignancies. The treatment is limited by progressive…”
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