Search Results - "Cancer cell international"

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment by Emami Nejad, Asieh, Najafgholian, Simin, Rostami, Alireza, Sistani, Alireza, Shojaeifar, Samaneh, Esparvarinha, Mojgan, Nedaeinia, Reza, Haghjooy Javanmard, Shaghayegh, Taherian, Marjan, Ahmadlou, Mojtaba, Salehi, Rasoul, Sadeghi, Bahman, Manian, Mostafa

“…Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow…”
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p53 signaling in cancer progression and therapy by Marei, Hany E, Althani, Asmaa, Afifi, Nahla, Hasan, Anwarul, Caceci, Thomas, Pozzoli, Giacomo, Morrione, Andrea, Giordano, Antonio, Cenciarelli, Carlo

“…The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene…”
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New insights into M1/M2 macrophages: key modulators in cancer progression by Liu, Jiuyang, Geng, Xiafei, Hou, Jinxuan, Wu, Gaosong

“…Abstract Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions…”
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Microsatellite instability: a review of what the oncologist should know by Li, Kai, Luo, Haiqing, Huang, Lianfang, Luo, Hui, Zhu, Xiao

“…The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from…”
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Challenges of applying multicellular tumor spheroids in preclinical phase by Han, Se Jik, Kwon, Sangwoo, Kim, Kyung Sook

“…The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is becoming an essential tool in cancer research as it expresses an intermediate…”
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Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment by Sharifi-Rad, Javad, Quispe, Cristina, Butnariu, Monica, Rotariu, Lia Sanda, Sytar, Oksana, Sestito, Simona, Rapposelli, Simona, Akram, Muhammad, Iqbal, Mehwish, Krishna, Akash, Kumar, Nanjangud Venkatesh Anil, Braga, Susana S., Cardoso, Susana M., Jafernik, Karolina, Ekiert, Halina, Cruz-Martins, Natália, Szopa, Agnieszka, Villagran, Marcelo, Mardones, Lorena, Martorell, Miquel, Docea, Anca Oana, Calina, Daniela

“…Abstract The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the…”
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The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review by Liu, Kai, Zheng, Minying, Lu, Rui, Du, Jiaxing, Zhao, Qi, Li, Zugui, Li, Yuwei, Zhang, Shiwu

“…Abstract One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of…”
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Clinical applications of artificial intelligence and machine learning in cancer diagnosis: looking into the future by Iqbal, Muhammad Javed, Javed, Zeeshan, Sadia, Haleema, Qureshi, Ijaz A., Irshad, Asma, Ahmed, Rais, Malik, Kausar, Raza, Shahid, Abbas, Asif, Pezzani, Raffaele, Sharifi-Rad, Javad

“…Abstract Artificial intelligence (AI) is the use of mathematical algorithms to mimic human cognitive abilities and to address difficult healthcare challenges…”
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Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets by Asgharian, Parina, Tazekand, Abbas Pirpour, Hosseini, Kamran, Forouhandeh, Haleh, Ghasemnejad, Tohid, Ranjbar, Maryam, Hasan, Muzaffar, Kumar, Manoj, Beirami, Sohrab Minaei, Tarhriz, Vahideh, Soofiyani, Saiedeh Razi, Kozhamzharova, Latipa, Sharifi-Rad, Javad, Calina, Daniela, Cho, William C

“…Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The…”
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circRNA-miRNA-mRNA regulatory network in human lung cancer: an update by Liang, Zhuo-Zheng, Guo, Cheng, Zou, Man-Man, Meng, Ping, Zhang, Tian-Tuo

“…Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular…”
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Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier by Vafaei, Somayeh, Zekiy, Angelina O, Khanamir, Ramadhan Ado, Zaman, Burhan Abdullah, Ghayourvahdat, Arman, Azimizonuzi, Hannaneh, Zamani, Majid

“…Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic strategy with encouraging therapeutic outcomes due to their durable…”
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The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer by Melissaridou, Styliani, Wiechec, Emilia, Magan, Mustafa, Jain, Mayur Vilas, Chung, Man Ki, Farnebo, Lovisa, Roberg, Karin

“…Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment…”
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Survivin: a unique target for tumor therapy by Garg, Himani, Suri, Prerna, Gupta, Jagdish C, Talwar, G P, Dubey, Shweta

“…Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These…”
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MicroRNA (miRNA) in cancer by Reddy, Kaladhar B

“…In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as…”
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Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp by Alfarouk, Khalid O, Stock, Christian-Martin, Taylor, Sophie, Walsh, Megan, Muddathir, Abdel Khalig, Verduzco, Daniel, Bashir, Adil H H, Mohammed, Osama Y, Elhassan, Gamal O, Harguindey, Salvador, Reshkin, Stephan J, Ibrahim, Muntaser E, Rauch, Cyril

“…Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most…”
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Acidic extracellular microenvironment and cancer by Kato, Yasumasa, Ozawa, Shigeyuki, Miyamoto, Chihiro, Maehata, Yojiro, Suzuki, Atsuko, Maeda, Toyonobu, Baba, Yuh

“…Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from…”
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The biological function of m6A demethylase ALKBH5 and its role in human disease by Wang, Jinyan, Wang, Jinqiu, Gu, Quan, Ma, Yajun, Yang, Yan, Zhu, Jing, Zhang, Quan’an

“…Abstract Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers…”
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Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight by Lohitesh, K, Chowdhury, Rajdeep, Mukherjee, Sudeshna

“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection…”
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The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers by Wang, Jinyan, Chen, Lijuan, Qiang, Ping

“…The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes…”
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The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors by Hou, Helei, Sun, Dantong, Zhang, Xiaochun

“…The MDM2 protein encoded by the mouse double minute 2 ( ) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein…”
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