Search Results - "Cancer cell"

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth by de Visser, Karin E., Joyce, Johanna A.

“…Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous cells, embedded in an altered extracellular matrix. The tumor…”
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Oxidative Stress in Cancer by Hayes, John D., Dinkova-Kostova, Albena T., Tew, Kenneth D.

“…Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution in apparently contradictory ways, either initiating/stimulating…”
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Conserved pan-cancer microenvironment subtypes predict response to immunotherapy by Bagaev, Alexander, Kotlov, Nikita, Nomie, Krystle, Svekolkin, Viktor, Gafurov, Azamat, Isaeva, Olga, Osokin, Nikita, Kozlov, Ivan, Frenkel, Felix, Gancharova, Olga, Almog, Nava, Tsiper, Maria, Ataullakhanov, Ravshan, Fowler, Nathan

“…The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused on genomic alterations. Transcriptomic analysis offers an…”
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Targeting Ferroptosis to Iron Out Cancer by Hassannia, Behrouz, Vandenabeele, Peter, Vanden Berghe, Tom

“…One of the key challenges in cancer research is how to effectively kill cancer cells while leaving the healthy cells intact. Cancer cells often have defects in…”
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The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker by Jardim, Denis L., Goodman, Aaron, de Melo Gagliato, Debora, Kurzrock, Razelle

“…Tumor mutational burden (TMB) reflects cancer mutation quantity. Mutations are processed to neo-antigens and presented by major histocompatibility complex…”
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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 by Liao, Peng, Wang, Weimin, Wang, Weichao, Kryczek, Ilona, Li, Xiong, Bian, Yingjie, Sell, Amanda, Wei, Shuang, Grove, Sara, Johnson, Jeffrey K., Kennedy, Paul D., Gijón, Miguel, Shah, Yatrik M., Zou, Weiping

“…Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown. Here, we discover that T cell-derived interferon (IFN)γ in combination with arachidonic…”
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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments by Kumagai, Shogo, Koyama, Shohei, Itahashi, Kota, Tanegashima, Tokiyoshi, Lin, Yi-tzu, Togashi, Yosuke, Kamada, Takahiro, Irie, Takuma, Okumura, Genki, Kono, Hidetoshi, Ito, Daisuke, Fujii, Rika, Watanabe, Sho, Sai, Atsuo, Fukuoka, Shota, Sugiyama, Eri, Watanabe, Go, Owari, Takuya, Nishinakamura, Hitomi, Sugiyama, Daisuke, Maeda, Yuka, Kawazoe, Akihito, Yukami, Hiroki, Chida, Keigo, Ohara, Yuuki, Yoshida, Tatsuya, Shinno, Yuki, Takeyasu, Yuki, Shirasawa, Masayuki, Nakama, Kenta, Aokage, Keiju, Suzuki, Jun, Ishii, Genichiro, Kuwata, Takeshi, Sakamoto, Naoya, Kawazu, Masahito, Ueno, Toshihide, Mori, Taisuke, Yamazaki, Naoya, Tsuboi, Masahiro, Yatabe, Yasushi, Kinoshita, Takahiro, Doi, Toshihiko, Shitara, Kohei, Mano, Hiroyuki, Nishikawa, Hiroyoshi

“…The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical…”
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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities by Gay, Carl M., Stewart, C. Allison, Park, Elizabeth M., Diao, Lixia, Groves, Sarah M., Heeke, Simon, Nabet, Barzin Y., Fujimoto, Junya, Solis, Luisa M., Lu, Wei, Xi, Yuanxin, Cardnell, Robert J., Wang, Qi, Fabbri, Giulia, Cargill, Kasey R., Vokes, Natalie I., Ramkumar, Kavya, Zhang, Bingnan, Della Corte, Carminia M., Robson, Paul, Swisher, Stephen G., Roth, Jack A., Glisson, Bonnie S., Shames, David S., Wistuba, Ignacio I., Wang, Jing, Quaranta, Vito, Minna, John, Heymach, John V., Byers, Lauren Averett

“…Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression…”
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A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications by Wright, George W., Huang, Da Wei, Phelan, James D., Coulibaly, Zana A., Roulland, Sandrine, Young, Ryan M., Wang, James Q., Schmitz, Roland, Morin, Ryan D., Tang, Jeffrey, Jiang, Aixiang, Bagaev, Aleksander, Plotnikova, Olga, Kotlov, Nikita, Johnson, Calvin A., Wilson, Wyndham H., Scott, David W., Staudt, Louis M.

“…The development of precision medicine approaches for diffuse large B cell lymphoma (DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical…”
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion by Su, Rui, Dong, Lei, Li, Yangchan, Gao, Min, Han, Li, Wunderlich, Mark, Deng, Xiaolan, Li, Hongzhi, Huang, Yue, Gao, Lei, Li, Chenying, Zhao, Zhicong, Robinson, Sean, Tan, Brandon, Qing, Ying, Qin, Xi, Prince, Emily, Xie, Jun, Qin, Hanjun, Li, Wei, Shen, Chao, Sun, Jie, Kulkarni, Prakash, Weng, Hengyou, Huang, Huilin, Chen, Zhenhua, Zhang, Bin, Wu, Xiwei, Olsen, Mark J., Müschen, Markus, Marcucci, Guido, Salgia, Ravi, Li, Ling, Fathi, Amir T., Li, Zejuan, Mulloy, James C., Wei, Minjie, Horne, David, Chen, Jianjun

“…Fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase, plays oncogenic roles in various cancers, presenting an opportunity…”
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Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer by Zhang, Yuanyuan, Chen, Hongyan, Mo, Hongnan, Hu, Xueda, Gao, Ranran, Zhao, Yahui, Liu, Baolin, Niu, Lijuan, Sun, Xiaoying, Yu, Xiao, Wang, Yong, Chang, Qing, Gong, Tongyang, Guan, Xiuwen, Hu, Ting, Qian, Tianyi, Xu, Binghe, Ma, Fei, Zhang, Zemin, Liu, Zhihua

“…In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA-…”
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Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance by Marusyk, Andriy, Janiszewska, Michalina, Polyak, Kornelia

“…Advances in our understanding of molecular mechanisms of tumorigenesis have translated into knowledge-based therapies directed against specific oncogenic…”
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Proteogenomic and metabolomic characterization of human glioblastoma by Gritsenko, Marina A., Kyle, Jennifer E., Cao, Song, Rykunov, Dmitry, Cornwell, MacIntosh, Petralia, Francesca, Wu, Yige, Reva, Boris, Kawaler, Emily, Olsen, Lindsey K., Liang, Wen-Wei, Wendl, Michael C., Caravan, Wagma, Ji, Jiayi, Petyuk, Vladislav A., Moon, Jamie, Moore, Ronald J., Krek, Azra, Zhu, Houxiang, McMichael, Joshua F., Lu, Shuangjia, Baral, Jessika, Yao, Lijun, Zink, Erika, Bloodsworth, Kent J., Satpathy, Shankha, Boca, Simina M., Chen, Feng, Ketchum, Karen A., Boja, Emily S., Hiltke, Tara, Mani, D.R., Chen, Xi S., Li, Qing Kay, Kim, Albert H., Fenyö, David, Mesri, Mehdi, Resnick, Adam C., Wang, Pei, Chheda, Milan G., Barnholtz-Sloan, Jill S., Rodland, Karin D., Liu, Tao, Ding, Li, Bauer, Thomas, Borucki, Melissa, Burke, Meghan C., Cai, Shuang, Calinawan, Anna P., Carr, Steven A., Chan, Daniel W., Charamut, Alyssa, Chesla, David, Chowdhury, Shrabanti, Cieślik, Marcin P., Culpepper, Houston, Demir, Emek, Dhir, Rajiv, Duffy, Elizabeth, Edwards, Robert, Gabriel, Stacey, Gabrovski, Nikolay, Garofano, Luciano, Gillette, Michael A., Hannick, Linda I., Hindenach, Barbara, Hoadley, Katherine A., Hostetter, Galen, Huang, Chen, Jaehnig, Eric, Ji, Nan, Jones, Corbin D., Kaspera, Wojciech, Lei, Jonathan, Li, Kai, Liu, Hongwei, Lubínski, Jan, Malc, Ewa, Malovannaya, Anna, McGarvey, Peter B., McGee, John, Mieczkowski, Piotr, Modugno, Francesmary, Ozbek, Umut, Paulovich, Amanda G., Piehowski, Paul D., Polonskaya, Larisa, Pruetz, Barbara, Ramkissoon, Shakti, Riggins, Gregory, Stawicki, Jakub, Tabor, Dave, Tansil, Darlene, Traer, Elie, Vatanian, Negin, Webster, Alex, Wen, Bo, Whiteaker, Jeffrey R., Zhang, Liwei, Zhao, Grace

“…Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment…”
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Acquired Resistance to Immune Checkpoint Inhibitors by Schoenfeld, Adam J., Hellmann, Matthew D.

“…Immune checkpoint inhibitors (ICIs) have rapidly altered the treatment landscape for multiple tumor types, providing unprecedented survival in some patients…”
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Overcoming Endocrine Resistance in Breast Cancer by Hanker, Ariella B., Sudhan, Dhivya R., Arteaga, Carlos L.

“…Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype. Treatment of ER+ breast cancer comprises interventions that suppress…”
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Engineering CAR-T Cells for Next-Generation Cancer Therapy by Hong, Mihe, Clubb, Justin D., Chen, Yvonne Y.

“…T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have shown remarkable success in treating patients with hematologic…”
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NRF2 and the Hallmarks of Cancer by Rojo de la Vega, Montserrat, Chapman, Eli, Zhang, Donna D.

“…The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive…”
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Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial by Wang, Zi-Xian, Cui, Chengxu, Yao, Jun, Zhang, Yanqiao, Li, Mengxia, Feng, Jifeng, Yang, Shujun, Fan, Yun, Shi, Jianhua, Zhang, Xizhi, Shen, Lin, Shu, Yongqian, Wang, Cailian, Dai, Tianyang, Mao, Teng, Chen, Long, Guo, Zengqing, Liu, Bo, Pan, Hongming, Cang, Shundong, Jiang, Yi, Wang, Junye, Ye, Min, Chen, Zhendong, Jiang, Da, Lin, Qin, Ren, Wei, Wang, Junsheng, Wu, Lin, Xu, Yong, Miao, Zhanhui, Sun, Meili, Xie, Conghua, Liu, Ying, Wang, Qifeng, Zhao, Lina, Li, Qi, Huang, Canhong, Jiang, Ke, Yang, Kunyu, Li, Daojun, Liu, Yunpeng, Zhu, Zhitu, Chen, Rixin, Jia, Liqun, Li, Wei, Liao, Wangjun, Liu, Hong-Xu, Ma, Daiyuan, Ma, Jie, Qin, Yanru, Shi, Zhihong, Wei, Qichun, Xiao, Ke, Zhang, Yan, Zhang, Ying, Chen, Xin, Dai, Guanghai, He, Jianxing, Li, Junhe, Li, Guanghui, Liu, Yong, Liu, Zhihua, Yuan, Xianglin, Zhang, Junping, Fu, Zhichao, He, Yifu, Ju, Fang, Liu, Zheng, Tang, Peng, Wang, Tiejun, Wang, Weibo, Zhang, Jing, Luo, Xianming, Tang, Xiongwen, May, Rena, Feng, Hui, Yao, Sheng, Keegan, Patricia, Xu, Rui-Hua, Wang, Feng

“…Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study…”
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Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation by Xiao, Yansen, Cong, Min, Li, Jiatao, He, Dasa, Wu, Qiuyao, Tian, Pu, Wang, Yuan, Yang, Shuaixi, Liang, Chenxi, Liang, Yajun, Wen, Jili, Liu, Yingjie, Luo, Wenqian, Lv, Xianzhe, He, Yunfei, Cheng, Dong-dong, Zhou, Tianhao, Zhao, Wenjing, Zhang, Peiyuan, Zhang, Xue, Xiao, Yichuan, Qian, Youcun, Wang, Hongxia, Gao, Qiang, Yang, Qing-cheng, Yang, Qifeng, Hu, Guohong

“…Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic…”
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The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes by Dammeijer, Floris, van Gulijk, Mandy, Mulder, Evalyn E., Lukkes, Melanie, Klaase, Larissa, van den Bosch, Thierry, van Nimwegen, Menno, Lau, Sai Ping, Latupeirissa, Kitty, Schetters, Sjoerd, van Kooyk, Yvette, Boon, Louis, Moyaart, Antien, Mueller, Yvonne M., Katsikis, Peter D., Eggermont, Alexander M., Vroman, Heleen, Stadhouders, Ralph, Hendriks, Rudi W., Thüsen, Jan von der, Grünhagen, Dirk J., Verhoef, Cornelis, van Hall, Thorbald, Aerts, Joachim G.

“…PD-1/PD-L1-checkpoint blockade therapy is generally thought to relieve tumor cell-mediated suppression in the tumor microenvironment but PD-L1 is also…”
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