Search Results - "Cancer biotherapy & radiopharmaceuticals"

Exosomal circFBLIM1 Promotes Hepatocellular Carcinoma Progression and Glycolysis by Regulating the miR-338/LRP6 Axis by Lai, Zhiwen, Wei, Tianning, Li, Qingming, Wang, Xianglong, Zhang, Yang, Zhang, Shengliang

“…Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Circular RNAs (circRNAs) play a vital role in cancer development and progression. This…”
Get more information

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches by Thiele, Nikki A, Wilson, Justin J

“…The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly promising for use in targeted α therapy (TAT), a therapeutic strategy…”
Get more information

Exosomal circ-HIPK3 Facilitates Tumor Progression and Temozolomide Resistance by Regulating miR-421/ ZIC5 Axis in Glioma by Han, Chengchen, Wang, Shuwei, Wang, Hongwei, Zhang, Jianning

“…The resistance of glioma patients to temozolomide (TMZ) treatment is a limiting factor in clinical treatment. Circular RNA HIPK3 (circ-HIPK3) was found to be…”
Get more information

Circ_0004913 Inhibits Cell Growth, Metastasis, and Glycolysis by Absorbing miR-184 to Regulate HAMP in Hepatocellular Carcinoma by Wu, Mingyuan, Sun, Tanlezi, Xing, Lianjun

“…Circular RNA (circRNA) can regulate the progression of hepatocellular carcinoma (HCC). However, the role and potential mechanism of circ_0004913 in HCC are not…”
Get more information

Targeted Alpha Therapy: Current Clinical Applications by Guerra Liberal, Francisco D C, O'Sullivan, Joe M, McMahon, Stephen J, Prise, Kevin M

“…α-Emitting radionuclides have been approved for cancer treatment since 2013, with increasing degrees of success. Despite this clinical utility, little is known…”
Get more information

The Role of miRNA in the Diagnosis, Prognosis, and Treatment of Osteosarcoma by Wang, Jicheng, Liu, Shizhang, Shi, Jiyuan, Li, Jingyuan, Wang, Songbo, Liu, Huitong, Zhao, Song, Duan, Keke, Pan, Xuezhen, Yi, Zhi

“…Osteosarcoma (OS) is one of the most common malignant tumors derived from mesenchymal tissue and is highly invasive, mainly in children and adolescents…”
Get more information

Circ_0011292 Enhances Paclitaxel Resistance in Non-Small Cell Lung Cancer by Regulating miR-379-5p/TRIM65 Axis by Guo, Chunhong, Wang, Hailiang, Jiang, Housen, Qiao, Liang, Wang, Xinli

“…Non-small cell lung cancer (NSCLC) is the most prevalent cancer in the world. Chemotherapy resistance is a major obstacle to NSCLC therapy. This study explored…”
Get more information

Realizing Clinical Trials with Astatine-211: The Chemistry Infrastructure by Lindegren, Sture, Albertsson, Per, Bäck, Tom, Jensen, Holger, Palm, Stig, Aneheim, Emma

“…Despite the consensus around the clinical potential of the α-emitting radionuclide astatine-211 ( At), there are only a limited number of research facilities…”
Get more information

Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA by Zhang, Zhen, Mei, Yan, Hou, Mingxing

“…Colorectal cancer (CRC) is one of the most common cancers worldwide. In this study, we explored the role of RNA binding motif protein 15 (RBM15)-mediated MyD88…”
Get more information

Molecular Targeted Drugs and Treatment of Colorectal Cancer: Recent Progress and Future Perspectives by Geng, Fang, Wang, Zheng, Yin, Hang, Yu, Junxian, Cao, Bangwei

“…Nowadays, colorectal cancer is the fourth most common type of tumor all over the world. When diagnosed, ∼50%-60% of tumors have metastasized, thus resulting in…”
Get more information

Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway by Yin, Hongqian, Cui, Xia

“…Temozolomide (TMZ) resistance is a serious hindrance in clinical chemotherapy for glioma. Circular RNA homeodomain interacting protein kinase 3 (circHIPK3) can…”
Get more information

Matrine Inhibits Proliferation, Invasion, and Migration and Induces Apoptosis of Colorectal Cancer Cells Via miR-10b/PTEN Pathway by Cheng, Yun, Yu, Chen, Li, Weibing, He, Yongming, Bao, Yuhua

“…Colorectal cancer (CRC) is the third most common malignancy worldwide. Matrine can act as a potential antitumor drug, and its antitumor activities have been…”
Get more information

Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p by Wang, Xinli, Wang, Hailiang, Jiang, Housen, Qiao, Liang, Guo, Chunhong

“…Lung cancer is a social problem of increasing concern, and non-small cell lung cancer (NSCLC) accounts for 80%-85% incidence of lung cancer. Cisplatin (DDP) is…”
Get more information

Circ_0109291 Promotes Cisplatin Resistance of Oral Squamous Cell Carcinoma by Sponging miR-188-3p to Increase ABCB1 Expression by Gao, Fei, Han, Jianjun, Wang, Yun, Jia, Lin, Luo, Wenjuan, Zeng, Yan

“…The occurrence of cisplatin (DDP) resistance in oral squamous cell carcinoma (OSCC) is a major challenge for OSCC treatment. Circular RNAs (circRNAs) have been…”
Get more information

Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma by Xue, Yang, Diao, Mingqiang, Lyu, Jing, Li, Kang, He, Long, Chen, Junfeng, Li, Xiangguo

“…Numerous studies have recorded the function of long noncoding RNAs (lncRNAs) in cancer development, including lung adenocarcinoma (LUAD). Previous studies have…”
Get more information

Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p by Zhao, Yue, Zhong, Rui, Deng, Chaoyue, Zhou, Zhenlin

“…Breast cancer (BC) is a common tumor in women worldwide, and irradiation (IR) resistance is a major obstacle for BC therapy. Circle RNAs (circRNAs) were…”
Get more information

Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis by Fang, Ke, Chen, Xuan, Qiu, Feng, Xu, Jinbiao, Xiong, Huanwen, Zhang, Zhanmin

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths all over the world. Exosomes exert central roles in intercellular communication…”
Get more information

Advances in Precision Oncology: Targeted Thorium-227 Conjugates As a New Modality in Targeted Alpha Therapy by Hagemann, Urs B, Wickstroem, Katrine, Hammer, Stefanie, Bjerke, Roger M, Zitzmann-Kolbe, Sabine, Ryan, Olav B, Karlsson, Jenny, Scholz, Arne, Hennekes, Hartwig, Mumberg, Dominik, Cuthbertson, Alan S

“…Targeted α therapy (TAT) offers the potential for the targeted delivery of potent α-particle-emitting radionuclides that emit high linear energy transfer…”
Get more information

miR-141-5p Affects the Cell Proliferation and Apoptosis by Targeting BTG1 in Cervical Cancer by Ni, Zhenzhen, Shen, Yan, Wang, Wei, Cheng, Xue, Fu, Yajuan

“…MicroRNAs have been discovered to have the possibility to play a significant role in cancer development. While miR-141-5p has been found upregulated in various…”
Get more information

Targeted Alpha Therapy with Thorium-227 by Frantellizzi, Viviana, Cosma, Laura, Brunotti, Gabriele, Pani, Arianna, Spanu, Angela, Nuvoli, Susanna, De Cristofaro, Flaminia, Civitelli, Liana, De Vincentis, Giuseppe

“…Targeted alpha therapy (TAT) can deliver high localized burden of radiation selectively to cancer cells as well as the tumor microenvironment, while minimizing…”
Get more information