Search Results - "Cancer Treatment Reviews"

Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook by Garcia, Josep, Hurwitz, Herbert I., Sandler, Alan B., Miles, David, Coleman, Robert L, Deurloo, Regula, Chinot, Olivier L

“…•Bevacizumab (Avastin®), a VEGF-A targeting monoclonal antibody, was the first approved angiogenesis inhibitor.•Approved in a range of solid tumor indications,…”
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Molecular targeted therapy of glioblastoma by Le Rhun, Emilie, Preusser, Matthias, Roth, Patrick, Reardon, David A., van den Bent, Martin, Wen, Patrick, Reifenberger, Guido, Weller, Michael

“…•Most glioblastomas are not “single pathway” diseases easily amenable to targeted therapy.•The core pathways altered in glioblastoma are challenging for…”
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Review of precision cancer medicine: Evolution of the treatment paradigm by Tsimberidou, Apostolia M., Fountzilas, Elena, Nikanjam, Mina, Kurzrock, Razelle

“…•Genomic studies have revealed that tumors are significantly heterogeneous and complex and therefore optimized therapy does not often result from classical…”
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CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy by Tokunaga, Ryuma, Zhang, Wu, Naseem, Madiha, Puccini, Alberto, Berger, Martin D, Soni, Shivani, McSkane, Michelle, Baba, Hideo, Lenz, Heinz-Josef

“…•Chemokines induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation.•The CXCL9, -10, -11/CXCR3 axis regulates immune cell…”
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Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors by Krishnamurthy, Nithya, Kurzrock, Razelle

“…[Display omitted] •Wnt is a family of proteins involved in stem cell renewal and organogenesis.•Wnt pathway activation occurs in many cancers and contributes…”
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Immunotherapy for pancreatic cancer: A 2020 update by Schizas, Dimitrios, Charalampakis, Nikolaos, Kole, Christo, Economopoulou, Panagiota, Koustas, Evangelos, Gkotsis, Efthymios, Ziogas, Dimitrios, Psyrri, Amanda, Karamouzis, Michalis V.

“…•Pancreatic adenocarcinoma (PAC) is associated with dismal prognosis.•Immunotherapy alone in unresectable PAC confers poor responses.•A clinical benefit is…”
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Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence by Raoul, Jean-Luc, Forner, Alejandro, Bolondi, Luigi, Cheung, Tan To, Kloeckner, Roman, de Baere, Thierry

“…•TACE is the standard-of-care for the treatment of intermediate stage HCC.•DEB-TACE is not superior to conventional TACE in efficacy and safety.•Several…”
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MYC as a target for cancer treatment by Duffy, Michael J., O'Grady, Shane, Tang, Minhong, Crown, John

“…•The MYC family of proto-oncogenes are frequently altered in human cancers and represent an attractive target for therapy.•Therapeutic targeting of MYC has…”
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Association between immune-related side effects and efficacy and benefit of immune checkpoint inhibitors – A systematic review and meta-analysis by Hussaini, Syed, Chehade, Rania, Boldt, Ronald Gabriel, Raphael, Jacques, Blanchette, Phillip, Maleki Vareki, Saman, Fernandes, Ricardo

“…•Immune checkpoint inhibitors can induce immune-related adverse events (irAEs), potentially life-threatening.•There is evidence suggesting a potential…”
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Tumor-associated macrophages in breast cancer: Innocent bystander or important player? by Qiu, Si-Qi, Waaijer, Stijn J.H., Zwager, Mieke C., de Vries, Elisabeth G.E., van der Vegt, Bert, Schröder, Carolien P.

“…•Tumor-associated macrophages (TAMs) are related to poor prognosis in breast cancer.•TAMs promote breast cancer cell growth, invasion and metastasis…”
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Targeting the microenvironment in solid tumors by Belli, Carmen, Trapani, Dario, Viale, Giulia, D'Amico, Paolo, Duso, Bruno Achutti, Della Vigna, Paolo, Orsi, Franco, Curigliano, Giuseppe

“…•Tumor microenvironment (TME) gets specific modifications during cancer progression.•Targeting different components of TME may overcome drug resistance.•It is…”
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The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target by Gambardella, V., Castillo, J., Tarazona, N., Gimeno-Valiente, F., Martínez-Ciarpaglini, C., Cabeza-Segura, M., Roselló, S., Roda, D., Huerta, M., Cervantes, A., Fleitas, T.

“…[Display omitted] •Tumor immune microenvironment signalling influences tumor progression.•Tumor associated macrophages are characterized by a dual pro- and…”
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Management of locally recurrent nasopharyngeal carcinoma by Lee, Anne W.M., Ng, Wai Tong, Chan, Jimmy Y.W., Corry, June, Mäkitie, Antti, Mendenhall, William M., Rinaldo, Alessandra, Rodrigo, Juan P., Saba, Nabil F., Strojan, Primož, Suárez, Carlos, Vermorken, Jan B., Yom, Sue S., Ferlito, Alfio

“…•Regular surveillance monitoring is needed for early detection of local recurrence.•Surgery should be considered whenever feasible due to its lower…”
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Current and emerging therapies for first-line treatment of metastatic clear cell renal cell carcinoma by Atkins, Michael B., Tannir, Nizar M.

“…•The first-line treatment landscape for RCC is evolving rapidly.•New options include cabozantinib and nivolumab/ipilimumab.•Evidence from pivotal trials helps…”
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Adenocarcinoma spectrum lesions of the lung: Detection, pathology and treatment strategies by Succony, L, Rassl, DM, Barker, AP, McCaughan, FM, Rintoul, RC

“…•Lung cancer outcomes are poor, with adenocarcinomas accounting for >50% of cases.•Preinvasive changes occur in the lung parenchyma before adenocarcinoma…”
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Management of toxicities of immune checkpoint inhibitors by Spain, Lavinia, Diem, Stefan, Larkin, James

“…Highlights • Role of immune checkpoint inhibition in the management of key malignancies. • Description of rates of immune-related adverse events and timing of…”
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Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy by Fujiwara, Yu, Kato, Shumei, Nesline, Mary K, Conroy, Jeffrey M, DePietro, Paul, Pabla, Sarabjot, Kurzrock, Razelle

“…•Indoleamine 2,3-dioxygenase (IDO) 1 degrades tryptophan, causing immunosuppression.•IDO1 inhibitors attenuate tryptophan depletion and immunosuppression.•IDO…”
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KRAS: From undruggable to a druggable Cancer Target by Uprety, Dipesh, Adjei, Alex A.

“…•RAS is the most frequently mutated oncogene in human cancers, accounting for approximately 30% of mutations in all human cancers.•Despite playing a distinct…”
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Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality by Kerr, Amanda J., Dodwell, David, McGale, Paul, Holt, Francesca, Duane, Fran, Mannu, Gurdeep, Darby, Sarah C., Taylor, Carolyn W.

“…•Clinical guidelines recommend > 20 adjuvant or neoadjuvant breast cancer options.•Randomised data on 1000–10,000 women are available for most options.•Breast…”
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Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs by Buffart, Laurien M, Kalter, Joeri, Sweegers, Maike G, Courneya, Kerry S, Newton, Robert U, Aaronson, Neil K, Jacobsen, Paul B, May, Anne M, Galvão, Daniel A, Chinapaw, Mai J, Steindorf, Karen, Irwin, Melinda L, M.Stuiver, Martijn, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M, Mutrie, Nanette, Daley, Amanda J, McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E, James, Erica L, Plotnikoff, Ron C, Arbane, Gill, Schmidt, Martina E, Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S, Sonke, Gabe S, van Harten, Wim H, Garrod, Rachel, Schmitz, Kathryn H, Winters-Stone, Kerri M, Velthuis, Miranda J, Taaffe, Dennis R, van Mechelen, Willem, Kersten, Marie-José, Nollet, Frans, Wenzel Jennifer, J, Wiskemann J, Joachim, Verdonck-de Leeuw, I.M, Brug, J

“…Highlights • This meta-analysis of individual patient data from 34 randomised controlled trials (n= 4,519 patients) found significant benefits of exercise…”
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