Search Results - "Cancado, Rodolfo"

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease by Ataga, Kenneth I, Kutlar, Abdullah, Kanter, Julie, Liles, Darla, Cancado, Rodolfo, Friedrisch, João, Guthrie, Troy H, Knight-Madden, Jennifer, Alvarez, Ofelia A, Gordeuk, Victor R, Gualandro, Sandra, Colella, Marina P, Smith, Wally R, Rollins, Scott A, Stocker, Jonathan W, Rother, Russell P

“…In this yearlong trial involving patients with sickle cell disease, crizanlizumab, an antibody to P-selectin, was associated with a 45% lower rate of pain…”
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Pyruvate kinase deficiency: novel mutations and a better understanding of the genotype-to-phenotype correlation in Brazilian patients by Cançado, Rodolfo Delfini

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Sickle Cell Disease in Brazil: Current Management by da Silva Araújo, Aderson, Silva Pinto, Ana Cristina, de Castro Lobo, Clarisse Lopes, Figueiredo, Maria Stella, Menosi Gualandro, Sandra Fátima, Olalla Saad, Sara Teresinha, Cançado, Rodolfo Delfini

“…Sickle cell disease (SCD) comprises inherited red blood cell disorders due to a mutation in the β-globin gene (c20A > T, pGlu6Val) and is characterized by the…”
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HFE hemochromatosis: an overview about therapeutic recommendations by Cancado, Rodolfo D, Alvarenga, Aline Morgan, Santos, Paulo Caleb Jl

“…Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency. Large advances in the knowledge on the hemochromatosis…”
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Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cell anemia by Vicari, Perla, Adegoke, Samuel A., Mazzotti, Diego Robles, Cançado, Rodolfo Delfini, Nogutti, Maria Aparecida Eiko, Figueiredo, Maria Stella

“…Sickle cell anemia (SCA), a disorder characterized by both acute and chronic inflammation, exhibits substantial phenotypic variability. Interleukin-1 beta…”
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Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation by Alvarenga, Aline Morgan, da Silva, Nathália Kozikas, Fonseca, Paula Fernanda Silva, Oliveira, Theo G.M., da Silva Monteiro, Jacilene Barbosa, Cançado, Rodolfo Delfini, Naoum, Flavio Augusto, Dinardo, Carla Luana, Brissot, Pierre, Santos, Paulo Caleb Junior Lima

“…Five main genes are associated with hemochromatosis; however, current studies show that, in addition to these genes, others may be associated with primary iron…”
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Maternal and perinatal outcomes in pregnant women with sickle cell disease: an update by Sousa, Viviane Teixeira de, Ballas, Samir K, Leite, Júlia Mota, Olivato, Maria Cristina Albe, Cancado, Rodolfo D

“…The aim of this study was to describe maternal and perinatal outcomes in pregnant women with sickle cell disease (SCD) followed at Santa Casa de Sao Paulo over…”
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Estimated mortality rates of individuals with sickle cell disease in Brazil: real-world evidence by Cançado, Rodolfo Delfini, Costa, Fernando Ferreira, Lobo, Clarisse, Migliavaca, Celina Borges, Falavigna, Maicon, Souza Filho, Homero C. R., Bueno, Carolina Tosin, Silva-Pinto, Ana Cristina

“…•The median age at death was 32 years (IQR, 19-46) among individuals with SCD and 69 years (IQR, 53-81) among the general population.•Individuals aged 1-9 and…”
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Priapism is associated with sleep hypoxemia in sickle cell disease by Roizenblatt, Marina, Figueiredo, Maria Stella, Cançado, Rodolfo Delfini, Pollack-Filho, Frederico, de Almeida Santos Arruda, Martha Mariana, Vicari, Perla, Sato, João Ricardo, Tufik, Sergio, Roizenblatt, Suely

“…We assessed penile rigidity during sleep and the relationship of sleep abnormalities with priapism in adults with sickle cell disease. This was a case-control…”
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Deferasirox in patients with iron overload secondary to hereditary hemochromatosis: results of a 1-yr Phase 2 study by Cançado, Rodolfo, Melo, Murilo R., de Moraes Bastos, Roberto, Santos, Paulo C. J. L., Guerra-Shinohara, Elivira M., Chiattone, Carlos, Ballas, Samir K.

“…This open‐label, prospective, phase 2 study evaluated the safety and efficacy of deferasirox (10 ± 5 mg/kg/d) in patients with hereditary hemochromatosis (HH)…”
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Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype by Adams, Paul, Altes, Albert, Brissot, Pierre, Butzeck, Barbara, Cabantchik, Ioav, Cançado, Rodolfo, Distante, Sonia, Evans, Patricia, Evans, Robert, Ganz, Tomas, Girelli, Domenico, Hultcrantz, Rolf, McLaren, Gordon, Marris, Ben, Milman, Nils, Nemeth, Elizabeta, Nielsen, Peter, Pineau, Brigitte, Piperno, Alberto, Porto, Graça, Prince, Dianne, Ryan, John, Sanchez, Mayka, Santos, Paulo, Swinkels, Dorine, Teixeira, Emerência, Toska, Ketil, Vanclooster, Annick, White, Desley

“…Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different…”
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Exercise-Induced Abnormal Increase of Systolic Pulmonary Artery Pressure in Adult Patients With Sickle Cell Anemia: An Exercise Stress Echocardiography Study by de Lima-Filho, Newton Nunes, Figueiredo, Maria Stella, Vicari, Perla, Cançado, Rodolfo, Carvalho, Antonio Carlos de Camargo, Bordin, José Orlando, Campos, Orlando

“…Background Pulmonary hypertension (PH) at rest is a risk factor for death in patients with sickle cell anemia (SCA). Exercise echocardiography (EE) can detect…”
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HAMP Gene Mutation Associated with Juvenile Hemochromatosis in Brazilian Patients by Fonseca, Paula Fernanda Silva, Cançado, Rodolfo Delfini, Uellendahl Lopes, Marly Maria, Correia, Edileide, Lescano, Manuel Antonio, Santos, Paulo Caleb Junior Lima

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Assessment of labile plasma iron in patients who undergo hematopoietic stem cell transplantation by Naoum, Flávio Augusto, Espósito, Breno Pannia, Ruiz, Lílian Piron, Ruiz, Milton Artur, Tanaka, Paula Yurie, Sobreira, Juliana Tavora, Cançado, Rodolfo Delfini, de Barros, José Carlos

“…Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). There is a…”
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Economic burden of sickle cell disease in Brazil by Silva-Pinto, Ana Cristina, Costa, Fernando F, Gualandro, Sandra Fatima Menosi, Fonseca, Patricia Belintani Blum, Grindler, Carmela Maggiuzzu, Souza Filho, Homero C. R, Bueno, Carolina Tosin, Cançado, Rodolfo D

“…Background Sickle cell disease (SCD) may cause several impacts to patients and the whole society. About 4% of the population has the sickle cell trait in…”
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Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis by Kutlar, Abdullah, Kanter, Julie, Liles, Darla K., Alvarez, Ofelia A., Cançado, Rodolfo D., Friedrisch, João R., Knight‐Madden, Jennifer M., Bruederle, Andreas, Shi, Michael, Zhu, Zewen, Ataga, Kenneth I.

“…The cell adhesion molecule P‐selectin plays a key role in the pathogenesis of a vaso‐occlusive crisis (VOC) in patients with sickle cell disease (SCD). In the…”
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Intravenous ferric carboxymaltose for the treatment of iron deficiency anaemia - reply by Cancado, Rodolfo Delfini, Friedrisch, João Ricardo

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Real-World Evidence of Crizanlizumab Showing Reductions in Vaso-Occlusive Crises and Opioid Usage in Sickle Cell Disease by DeBonnett, Laurie, Joshi, Vikas, Silva-Pinto, Ana Cristina, Colombatti, Raffaella, Pasanisi, Annamaria, Arcioni, Francesco, Cançado, Rodolfo D, Sarp, Séverine, Sarkar, Rajendra, Soliman, Wesam

“…Access to crizanlizumab, a disease-modifying therapy for sickle cell disease (SCD), was provided through a managed access program (MAP, NCT03720626). The…”
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Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-α,β on monocytes from patients with warm autoimmune hemolytic anemia by Barros, Melca M.O., Yamamoto, Mihoko, Figueiredo, Maria S., Cançado, Rodolfo, Kimura, Elisa Y.S., Langhi Jr, Dante M., Chiattone, Carlos S., Bordin, Jose O.

“…BACKGROUND: Animal models have shown that CD47‐deficient mice develop severe autoimmune hemolytic anemia (AIHA) because the binding of red blood cell (RBC)…”
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Real-world evidence of the burden of sickle cell disease: a 5-year longitudinal study at a Brazilian reference center by Barros, Gisele Dos Santos, Leal, Carla Vaneska Fernandes, Leite, Lauro Augusto Caetano, Fujimoto, Denys Eiti, Cançado, Rodolfo Delfini

“…Sickle cell disease (SCD) is an inherited and multisystem blood disorder characterized by hemolytic anemia, vaso-occlusive crises (VOCs), progressive…”
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