Nasal eosinophilia can predict bronchial hyperresponsiveness in persistent rhinitis: evidence for united airways disease concept

Nasal eosinophilia can predict bronchial hyperresponsiveness in persistent rhinitis: evidence for united airways disease concept

Nasal eosinophils may be indicative of bronchial hyperresponsiveness (BHR) in rhinitis concerning the "united airways disease" theory. This study was designed to evaluate the relationship between nasal eosinophilia and BHR in persistent perennial rhinitis patients. Thirty-seven patients (1...

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Bibliographic Details
Published in:American journal of rhinology & allergy Vol. 25; no. 2; pp. 120 - 124
Main Authors: Canbaz, Pelin, Uskudar-Teke, Havva, Aksu, Kurtulus, Keren, Metin, Gulbas, Zafer, Kurt, Emel
Format: Journal Article
Language:English
Published: United States 01-03-2011
Subjects:
Adult
Bronchial Hyperreactivity
Bronchial Provocation Tests
Cell Count
Eosinophilia
Female
Humans
Male
Middle Aged
Models, Biological
Paranasal Sinuses - pathology
Predictive Value of Tests
Prognosis
Rhinitis, Allergic, Perennial - diagnosis
Rhinitis, Allergic, Perennial - pathology
Rhinitis, Allergic, Perennial - physiopathology
Skin Tests
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Summary:Nasal eosinophils may be indicative of bronchial hyperresponsiveness (BHR) in rhinitis concerning the "united airways disease" theory. This study was designed to evaluate the relationship between nasal eosinophilia and BHR in persistent perennial rhinitis patients. Thirty-seven patients (12 males and 25 females, mean age: 33.3 ± 10.4 years) were included in the study. Skin-prick test, nasal symptom score, nasal smears, methacholine bronchial challenge test, and nasal rhinometry were obtained in all patients. Eosinophil count in nasal smears was expressed as a percentage of the total cells. None of the patients had asthma. There was no difference between the number of atopic and nonatopic patients having BHR (4/20 versus 4/17; chi-squared = 0.07; p > 0.05). Total nasal flow was lower and percentage of nasal eosinophils was higher in the patients with BHR than in patients without BHR (p = 0.012 and p = 0.009, respectively). A cutoff point of 68% nasal eosinophils yielded a sensitivity of 100% (63.1-100) and a specificity of 58.6% (38.9-76.5) to determine the presence of BHR. Positive likelihood ratio for the value of eosinophils above cutoff value was 2.42 (1.8-3.3). This study shows the relationship between nasal eosinophils and BHR in persistent perennial rhinitis patients. Nasal eosinophil percentage below cutoff value indicates that a patient does not have BHR.
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ISSN:1945-8924
1945-8932
DOI:10.2500/ajra.2011.25.3574